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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Assessment of convection, hot-air combined with microwave- vacuum and freeze- drying methods for mushrooms with regard to product quality 显示文摘 | Dimitrios A Albert H Joachim M | 2011 | International Journal of Food Science and Technology2011，46，： | 1 |
| 3 | Vascular changes in the periosteum of congenital pseudarthrosis of the tibia 显示文摘 | Benita HS Jan S Joachim A | 2005 | Pathol Res Pract2005，201，： | 1 |
| 4 | Comparison of viability assays for Cryptosporidium parvum oocysts' after disinfection 显示文摘 | Joachim A Eckert E Petry F | 2003 | Veterinary Parasitology2003，111，1： | 1 |
| 5 | Signaling danger: Toll- Like receptors and their potential roles in kidney disease 显示文摘 | Hans- Joachim A Bernhard B Detlef S | 2004 | J Am Soc Nephrel2004，15，： | 1 |
| 6 | Electronics using hybrid molecular and mono molecular devices显示文摘 | Joachim C Girazewski J K Aviram A | 2000 | Nature London2000，405，： | 1 |
| 7 | Band-gap narrowing in heavily doped silicon: A comparison of optical and electrical data显示文摘 | Wagner Joachim del Alamo Jesus A | 1988 | Journal of Applied Physics1988，63，： | 1 |
| 8 | Active Damping of Drive Train Oscillations for an Electrically Driven Vehicle 显示文摘 | Notker A Joachim B Franz P | 2004 | IEEE/ASME Transaction on Mechatronics2004，9，4： | 1 |
| 9 | Encephalitozoonosis in rabbits显示文摘 | Kunzel F Joachim A | 2010 | Parasitol Res2010，106，2： | 1 |
| 10 | Influence of imidazole replacement in different structural classes of histamine H-receptor antagonists 显示文摘 | Galina M Joachim A Ulrich R | 2001 | Eur J Pharm Sei2001，13，3： | 1 |
| 11 | Recent Analysis of Key Plasma Wall Interactions Issues for ITER 显示文摘 | Joachim Roth Tsitrone E Loarte A | 2009 | Nucl Mater2009，，： | 1 |
| 12 | The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response显示文摘 | Joachim R Zenclussen A C Polgar B | 2003 | Steriods2003，68，1013： | 1 |
| 13 | Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study显示文摘 | Jadwiga A Wedzicha Marc Decramer Joachim H Ficker Dennis E Niewoehner Thomas Sandstr?m Angel Fowler Taylor Peter D’Andrea Christie Arrasate Hungta Chen Donald Banerji | 2013 | The Lancet Respiratory Medicine2013，，3： | 1 |
| 14 | Adjuvant Postoperative Radiation Therapy after Curative Resection of Squamous Cell Carcinoma of the Thoracic Esophagus: A prospective Randomized Study 显示文摘 | Hans LL ieren Joachim M Muller Christoph A Jacobi | 1995 | World J Surg1995，19，： | 1 |
| 15 | Electronics using hybrid-molecular and mono-molccular devices 显示文摘 | Joachim C Gimzewski J K Aviram A | 2000 | Nature2000，408，： | 1 |
| 16 | Microwave Processing of Natural Biopolymers-studies on the Properties of Different Starches显示文摘 | Magdolna H Joachim U | 2005 | International Journal of Pharmaceutics2005，302，： | 1 |
| 17 | Interactive classification of porcine Eimeria spp by computer-assited image analysis显示文摘 | Plitt A Imaron S Joachim A | 1999 | Vet Parasitol1999，86，： | 1 |
| 18 | Antioxidants in treatment of idiopathic sudden hearing loss显示文摘 | Joachims HZ Segal J Golz A | 2003 | Otol Neurotol2003，24，： | 1 |
| 19 | Introducing a mouse model for preeclampsia: adoptive transfer of ctivated Th1 cells leads to preeclampsia-like symptoms exclusively in pregnant mice显示文摘 | Zenclussen A C Fest S Joachim R | 2004 | Eur J Immunol2004，34，2： | 1 |
| 20 | Electronics using hybrid - molecular and mono - molecular devices 显示文摘 | JOACHIM C GIMZEWSKI J K AVIRAM A | 2000 | Nature2000，408，6812： | 1 |
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