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| 1 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | 青光眼患者血清抗视网膜抗原的抗体轮廓质谱分析显示文摘目的比较原发性开角型青光眼(POAG)患者与正常对照(CTRL)者间的抗体轮廓差异。方法病例对照研究。将44例POAG患者与48例CTRL者的血清分别加入到含有预洗Dyna珠-G蛋白的反应管中,以捕获人免疫球蛋白G(IgG)抗体,形成的IgG—G蛋白复合体用来捕获目标抗原(匀质化牛视网膜组织)。经洗提后获得的抗原蛋白通过“表面增强激光解吸附-电离-飞行时间-质谱”仪进行检测。采用Proteomic software project统计学软件,对两组质谱数据连同受检者年龄和性别等参数,自动进行t检验和初步多变量判别分析;随后采用Statistica version8.0统计学软件,进行包括抗原蛋白质谱数据、蛋白质芯片类型和激光解吸附-电离能量等的多变量判别分析。结果CTRL组的平均质谱强度为4244.427±4721.115,POAG组为4049.864±4083.819,两组间差异有统计学意义(F=1.340,P〈0.01);在POAG患者中,出现了部分高调节免疫反应,但主要表现为低调节免疫反应。结论在POAG患者与CTRL者之间存在明显的抗体轮廓差异,在POAG组中出现的低调节免疫反应表明部分患者可能与“异常免疫”有关。 | 严良 Joachim S. C Pfeiffer N Grus F.H Erb C | 2009 | 中华眼科杂志2009，45，7： | 3 |
| 4 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 5 | Atrial fibrillation associated minK 38G/S polymorphism modulates delayed rectifier current and membrane localization显示文摘 | Stephen Z Pierre C | 2005 | Cardiovasc Res2005，67，： | 1 |
| 6 | Radiation effects on poly (lactide-co-glycolide) ( PLGA ) and poly ( L-lactide ) (PLLA) 显示文摘 | Joachim L S C Ooi C P Freddy B Y C | 2004 | Polym Degrad Stab2004，83，2： | 1 |
| 7 | Nanoscale science of single molecules using local probes显示文摘 | Gimzewski J K Joachim C | 1999 | Science1999，283，： | 1 |
| 8 | Distortion Invariant Object Recognition in the Dynamic Link Architecture显示文摘 | Matin Lades Jan C Vorbruggen Joachim Buhmann | 1993 | IEEE Trans on Computer1993，42，3： | 1 |
| 9 | Electronics using hybrid molecular and mono molecular devices显示文摘 | Joachim C Girazewski J K Aviram A | 2000 | Nature London2000，405，： | 1 |
| 10 | Permeability' Prediction Based on Fractal Pore-Space Geometry显示文摘 | Pape H Clauser C Joachim I | 1999 | Geophysics1999，64，5： | 1 |
| 11 | Europhys Lett显示文摘 | Ondarcuhu T Joachim C | 1998 | 42(2):2151998，42，2： | 1 |
| 12 | Drawing a single nanofibre over hundreds of microns显示文摘 | Ondarcuhu T Joachim C | | 0，，02： | 1 |
| 13 | Cerebral subcortical small vessel disease in subjects with pathologically confirmed Alzheimer disease, a clinic pathologic study in the Oxford Project to Investigate Memory and Ageing ( OPTIMA ) 显示文摘 | Esiri MM Joachim C Slaan C | 2014 | Alzheimer Dis Assoe Disord2014，28，1： | 1 |
| 14 | Cutting-plane training of structural SVMs显示文摘 | Joachims T Finley T Yu C N J | 2009 | Machine Learning2009，77，1： | 1 |
| 15 | The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response显示文摘 | Joachim R Zenclussen A C Polgar B | 2003 | Steriods2003，68，1013： | 1 |
| 16 | Drawing a single nano- fibre over hundreds of microns 显示文摘 | ONDARCUHU T JOACHIM C | 1998 | Europhysies Let- ters1998，42，2： | 1 |
| 17 | Electronics using hybrid-molecular and mono-molccular devices 显示文摘 | Joachim C Gimzewski J K Aviram A | 2000 | Nature2000，408，： | 1 |
| 18 | lmmunohistochemical detection of estrogen receptor c in articular chondrocytes from cows,pigs and humans:in situ and in vitro results显示文摘 | Horst C Joachim H Michael S | 2001 | Ann Anat2001，183，： | 1 |
| 19 | Tuberculous brain abscess显示文摘 | Gonzalez P Herrero C Joachim G | 1980 | Neurosurgery1980，52，3： | 1 |
| 20 | Nanoscale science of single molecules using local probes 显示文摘 | Gimzewski J K Joachim C | 1999 | Science1999，238，5408： | 1 |
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