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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | 新致病基因在颅缝早闭Crouzon综合征中的初步机制研究显示文摘目的研究Rbp4(Retinol binding protein 4)、Gpc3(Glypican family of growth factor binding protein 3)、C1qtnf3(Collagenous repeat-containing sequence of 26 KDa protein)等新致病基因在颅缝早闭症中的发病机制,为疾病非手术治疗奠定理论基础。方法以Crouzon综合征Fgfr2cC342Y/+小鼠为实验模型,应用MicroCT和组织学染色,研究小鼠颅缝闭合模式;以Fgfr2cC342Y/+模型,RT-qPCR研究Rbp4、Gpc3、C1qtnf3等新致病基因的表达差异,初步探讨其在颅缝闭合过程中的调控作用;以体外培养的Fgfr2cC342Y/+小鼠颅缝细胞为模型,研究基因突变动物细胞增殖与代谢改变。结果获得Fgfr2cC342Y/+小鼠后额缝、冠状缝、人字缝、矢状缝等颅缝闭合模式,随颅骨发育、颅缝闭合,OC(Osteocalcin)、ALP(Alkalinephosphatase)表达增加,目的基因Rbp4、Gpc3、C1qtnf3表达下降,Msx2(Muscle segment homeobox gene 2)表达增加,杂合子与野生型小鼠之间均存在显著统计学差异,与前期人颅缝组织Microarray研究结果一致。Gpc1(Glypican family ofgrowth factor binding protein 1)、FliI(Flightless I)在颅缝闭合中的表达较恒定,野生型与杂合子之间未见明显统计学差异。体外培养Fgfr2cC342Y/+小鼠颅缝细胞,CellTiter96 MTS和Quant-iT Picogreen dsDNA细胞增殖与代谢分析结果显示,Fgfr2功能获得性突变可促进冠状缝细胞的增殖,从而导致成骨增加,颅缝早闭。结论 Fgfr2cC342Y/+模型新致病基因表达趋势与前期人颅缝组织Microarray研究结果一致,Rbp4、Gpc3、C1qtnf3可能在颅缝早闭中具重要调控作用。 | 杨娴娴 Jodie T Hatfield Susan J Hinze 穆雄铮 Peter J Anderson Barry C Powell | 2012 | 组织工程与重建外科杂志2012，8，5： | 3 |
| 3 | Analysis of 77000 canine uroliths 显示文摘 | Carl A Jody P David J etal | 1999 | Vet Clin Nor Am: Smal Anita Prac1999，29，1： | 1 |
| 4 | A Process to Re- cover Carbon Fibers From Polymer Matric Composites in End- of-Life Vehicles显示文摘 | Jody B J Pomykala J A Daniels E J | 2004 | J Mater2004，56，8： | 1 |
| 5 | Recovering CO2 from Large- Size and Medium - Size Stationary Combustors 显示文摘 | A M Wolsky E J Daniels B J Jody | 1991 | Journal of the Air & Waste Management Associa- tion1991，41，4： | 1 |
| 6 | The SAND domain structure defines a novel DNA-binding fold intranscriptional regulation显示文摘 | COLLARD MICHAEL W HUGGENVIK JODI I | 2001 | Nature Struct Biol2001，8，： | 1 |
| 7 | Learning preference,computer attitudes,and student evaluation of computerized instruction显示文摘 | Dvid J Jodi E Thomas G | 2002 | Medical Education2002，36，： | 1 |
| 8 | Nitrate in groundwaters of intensive agricultural areas in coastal Northeastern Australia显示文摘 | Peter J Thorburn Jody S Biggs Keith L Weier Brian A Keating | 2002 | Agriculture Ecosystems and Environment2002，，1： | 1 |
| 9 | On the influence of temperature on the refraction of ligh显示文摘 | JODIE | 1958 | Philtrans1958，148，： | 1 |
| 10 | Recovering CO2 from large and medium size stationary combustors显示文摘 | Wolsky A M Daniels E J Jody K S | 1991 | Journal of the air and waster management association1991，41，44： | 1 |
| 11 | On the Influence of Temperature on the Refraction of Light显示文摘 | GLANDSTONE J H JODIE | 1958 | Philtrans1958，，： | 1 |
| 12 | Measuring the evolution and output of cross-disciplinary collaborations within the NCI Physical Sciences- Oncology Centers Network显示文摘 | Jodi E B Katrina I T Unni S J | 2013 | Research E- valuation2013，22，： | 1 |
| 13 | The SAND domain structure defines a novel DNA-binding fold intranscriptional regulation 显示文摘 | BOTTOMLEY M J COLLARD MICHAEL W HUGGENVIK JODI I | 2001 | Nature Struct Biol2001，8，7： | 1 |
| 14 | Particle size,volume fraction and matrix strength effects on fatigue behavior and particle fracture in 2124 aluminum-SiCp composites显示文摘 | Jody N Hall Wayne Jones J Anil K | 1994 | Mater Sci Eng1994，183，： | 1 |
| 15 | CO2 Capture from the Flue Cras of Conventional Fossil-Fuel-Fired Power Plants显示文摘 | Wolsky A M Daniels E J Jody B J | 1994 | Environ Prog1994，13，2： | 1 |
| 16 | Marital Happiness, Marital Duration and the U-shaped Curve: Evidence from a Five- wave Panel Study 显示文摘 | Jody V L David R J Paul R A | 2001 | Social Forces2001，，4： | 1 |
| 17 | Junction Adhesion Molecule Is a Receptor for Reovirus显示文摘 | Erik S Barton J.Craig Forrest Jodi L Connolly James D Chappell Yuan Liu Frederick J Schnell Asma Nusrat Charles A Parkos Terence S Dermody | 2001 | Cell2001，，： | 1 |
| 18 | Nitrate in groundwaters of intensive agricultural areas in coastal Northeastern Australia显示文摘 | Peter J Thorburn Jody S Biggs Keith L Weier Brian A Keating | 2002 | Agriculture, Ecosystems and Environment2002，，1： | 1 |
| 19 | Use of NIR and pyrolysis-MBMS coupled with multivariate analysis for detecting the chemical changes associated with brown-rot biodegradation of spruce wood显示文摘 | STEPHEN S K JODY J BARRY G | 2002 | FEMS Microbiology Letters2002，209，： | 1 |
| 20 | Cost Effective Recovery of Thermo-Plastics from Mixed-scrap 显示文摘 | Jody B J Pomykala E Daniels | 2003 | Materials Technology2003，18，1： | 1 |
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