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| 1 | Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+T lymphocytes显示文摘 | Joffre O Gorsse N Romagnoli P | 2004 | Blood2004，103，11： | 1 |
| 2 | Awareness,treatment,and con-trol of hypertension in Canada显示文摘 | Joffres MR Ghadirian P Fodor JG | 1997 | Am J Hypertens1997，10，10： | 1 |
| 3 | Induction of antigen-specific tolerance to bone marrow allografts with CD4^+CD25^+T lymphocytes 显示文摘 | Joffre O Gorsse N Romagnoli P | 2004 | Blood2004，103，11： | 1 |
| 4 | Awareness,treatment and control of hypertension in Canada显示文摘 | Joffres MR Ghadirian P Fodor JG | 1997 | Am J Hypertens1997，10，： | 1 |
| 5 | MRI/CT x-ray comparison in the pre-operative evaluation of cancer of the larynx显示文摘 | Joffre P Giron J Fraqa J | 1988 | J Radiol1988，69，67： | 1 |
| 6 | Some theoretical properties of the OPLS method显示文摘 | Verron T Sabatier P Joffre R | 2004 | Chemometrics2004，18，： | 1 |
| 7 | Induction of antigen-specific tolerance to bone marrow allografts with CD4^+CD25^+ T lymphocytes显示文摘 | Joffre O Gorsse N Romagnoli P | 2004 | Blood2004，103，11： | 1 |
| 8 | Awareeness, treat-ment,and control of hypertention in Canada显示文摘 | Joffres MR Ghadirian P Fodor JG | 1997 | Am J Hypertens1997，10，： | 1 |
| 9 | Induction of antigenspecific tolerance to bone marrow allografts with CD4^+CD25^+ T lymphocytes显示文摘 | Joffre O Gorsse N Romagnoli P | 2004 | Blood2004，103，： | 1 |
| 10 | Experimental demonstration of a phased-array antenna optically controlled with phase and timedelays显示文摘 | DOLFI D JOFFRE P HUIGNARD J P | 1996 | Applied Optics1996，35，9： | 1 |
| 11 | 自然杀伤细胞的遗传缺失或高反应性不影响动脉粥样硬化发展显示文摘慢性炎症是动脉粥样硬化发展的重要因素,涉及先天免疫和适应性免疫。尽管一些研究已经评估了自然杀伤细胞(natural killer cells,NK)在动脉粥样硬化实验动物模型中的功能,但NK细胞是否可以抑制或促进动脉粥样硬化尚不清楚。先前研究的不足之处在于在靶向丧失或增强NK细胞功能方面缺乏特异性。 | 刘莉 叶鹏 Nour-Eldine W Joffre J Zibara K Giraud A Esposito B Zeboudj L Vilar J Terada M Bruneval P Vivier E Ait-Oufella H Mallat Z Ugolini S Tedgui A | 2017 | 中华高血压杂志2017，25，12： | 1 |
| 12 | Specific functional signature in soil macroinvertebrate biostructures 显示文摘 | Hedde M Lavene P Joffre R Jimenez J J Decaens T | 2005 | Functional Ecology2005，195，： | 1 |
| 13 | Prevention of acute and chronic allograft rejection w ith CD4+CD25+Foxp3+regulatory T lymphocytes显示文摘 | Joffre O Santolaria T Calise D Al Saati T Hudrisier D Romag-noli P | 2008 | Nat Med2008，14，1： | 1 |
| 14 | CD4^+CD25^+ regulatory T lymphocytes in bone marrow transplantation显示文摘 | Joffre O Van Meerwijk J P | 2006 | Seminars Immunology2006，18，： | 1 |
| 15 | The use of NIRS in litter decomposition studies显示文摘 | JOFFRE R GILLON D DARDENCE P | 1992 | Ann Sci forest1992，49，： | 1 |
| 16 | Experimental demonstration of a phased-array antenna optically controlled with phased and time delays显示文摘 | D Dolft P Joffre | 1996 | Applied Optics1996，35，26： | 1 |
| 17 | Experimental demonstration of a phased-array antenna optically controlled with phase and time delays显示文摘 | DOLFI D JOFFRE P HUIGNARD J P | 1996 | Applied Optics1996，35，9： | 1 |
| 18 | Hydroprocessing of substituted benzenes over a sulfided CoO-MoO3γ-Al2 O3 catalyst显示文摘 | MOREAU C JOFFRE J SAENZ C GENESTE P | 1990 | J Catal1990，122，2： | 1 |
| 19 | Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil:A national survey显示文摘AIM To evaluate bacterial resistance to clarithromycin and fluoroquinolones in Brazil using molecular methods.METHODS The primary antibiotic resistance rates of Helicobacter pylori(H. pylori) were determined from November 2012 to March 2015 in the Southern,South-Eastern,Northern,North-Eastern,and Central-Western regions of Brazil. Four hundred ninety H. pylori patients [66% female,mean age 43 years(range: 18-79)] who had never been previously treated for this infection were enrolled. All patients underwent gastroscopy with antrum and corpus biopsies and molecular testing using Geno Type Helico DR(Hain Life Science,Germany). This test was performed to detect the presence of H. pylori and to identify point mutations in the genes responsible for clarithromycin and fluoroquinolone resistance. The molecular procedure was divided into three steps: DNA extraction from the biopsies,multiplex amplification,and reverse hybridization. RESULTS Clarithromycin resistance was found in 83(16.9%) patients,and fluoroquinolone resistance was found in 66(13.5%) patients. There was no statistical difference in resistance to either clarithromycin or fluoroquinolones(P = 0.55 and P = 0.06,respectively) among the different regions of Brazil. Dual resistance to clarithromycin and fluoroquinolones was found in 4.3%(21/490) of patients. The A2147 G mutation was present in 90.4%(75/83),A2146 G in 16.9%(14/83) and A2146 C in 3.6%(3/83) of clarithromycin-resistant patients. In 10.8%(9/83) of clarithromycin-resistant samples,more than 01 mutation in the 23 S r RNA gene was noticed. In fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. D91 N mutation was observed in 34.8%(23/66),D91 G in 18.1%(12/66),N87 K in 16.6%(11/66) and D91 Y in 13.6%(9/66) of cases. Among fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. CONCLUSION The H. pylori clarithromycin resistance rate in Brazil is at the borderline(15%-20%) for applying the standard triple therapy. The fluoroquinolone resistance rate(13.5%) is equally concerning. | Bruno Squarcio Sanches Gustavo Miranda Martins Karine Lima Bianca Cota Luciana Dias Moretzsohn Laercio Tenorio Ribeiro Helenice P Breyer Ismael Maguilnik Aline Bessa Maia Joffre Rezende-Filho Ana Carolina Meira Henrique Pinto Edson Alves Ramiro Mascarenhas Raissa Passos Julia Duarte de Souza Osmar Reni Trindade Luiz Gonzaga Coelho | 2016 | World Journal of Gastroenterology2016，22，33： | 1 |
| 20 | Distribution of blood pressure and hypertension in Canada and the United States显示文摘 | Joffres MR Hamet P MacLean DR | 2001 | Am J Hypertens2001，14，111： | 1 |
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