|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anterior muscle sparing approach for total hip arthroplasty显示文摘The purpose of this review is to examine the validity of positive claims regarding the direct anterior approach(DAA) with a fracture table for total hip arthroplasty. Recent literature regarding the DAA was searched and specific claims investigated including improved early outcomes, speed of recovery, component placement, dislocation rates, and complication rates. Recent literature is positive regarding the effects of total hip arthroplasty with the anterior approach. While the data is not definitive at present, patients receiving the anterior approach for total hip arthroplasty tend to recover more quickly and have improved early outcomes. Component placement with the anterior approach is more often in the 'safe zone' than with other approaches. Dislocation rates tend to be less than 1% with the anterior approach. Complication rates vary widely in the published literature. A possible explanation is that the varianceis due to surgeon and institutional experience with the anterior approach procedure. Concerns remain regarding the 'learning curve' for both surgeons and institutions. In conclusion, it is not a matter of should this approach be used, but how should it be implemented. | Joseph T Moskal Susan G Capps John A Scanelli | 2013 | World Journal of Orthopedics2013，4，1： | 47 |
| 2 | Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease显示文摘在胆汁的树上的 Basic 和翻译创伤愈合研究在皮和胃肠道上在类似的研究后面显著地落后。这是至少对为学习的胆道的容易的存取的缺乏部分可归因。但是临床的关联,对胆汁的上皮的房间(BEC ) 的更多的兴趣 BEC 文化的病理生理学,和普遍可获得性是颠倒这个趋势的因素。在额外肝的胆汁的树上,徒劳的创伤愈合,结疤,苛评开发紧迫发出。在损害的最小的 intra 肝的胆汁管任何一个, BEC 增长或繁的回答能贡献肝疾病。在大、小的胆汁管的慢性炎和坚持的创伤愈合反应经常导致肝癌症。当他们适用于胆道,依赖于表明小径的 IL-6/gp130/STAT3 的细胞的过程的重要性,未答复的问题,和未来方向,愈合的创伤的一般概念被讨论。 | A J Demetris John G Lunz Ⅲ Susan Specht Isao Nozaki | 2006 | World Journal of Gastroenterology2006，12，22： | 15 |
| 3 | 汽车用钢的最新研究进展显示文摘为满足提高燃油效率及汽车'轻量化'等方面持续的需求,学术界及工业领域一直都很重视钢铁及其替代材料的研发,这两类材料之间的竞争始终十分激烈。对汽车用钢在北美的研究现状进行了概述,并重点介绍了几种冷轧和热轧汽车用钢的研究进展及其生产情况。新一代先进高强钢的发展将依然令人关注并充满机遇。 | John G Speer David K Matlock Emmanuel de Moor Grant A Thomas 周澍(译) 李晟(校) | 2013 | 世界钢铁2013，，5： | 10 |
| 4 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 5 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 6 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 7 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 8 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 9 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 10 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 11 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 12 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 13 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 14 | Hospitalized prevalence and 5-year mortality for IBD:Record linkage study显示文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. | Lori A Button Stephen E Roberts Michael J Goldacre Ashley Akbari Sarah E Rodgers John G Williams | 2010 | World Journal of Gastroenterology2010，16，4： | 3 |
| 15 | Real-time monitoring and control of sequencing batch reactors for secondary treatment of a poultry processing wastewater 显示文摘 | Pierson John A Pavlostathis Spyros G | 2000 | Water Environment Researeh2000，72，5： | 2 |
| 16 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 17 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 18 | The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis显示文摘 | John A Tuszynski G | 2001 | Pathol Oncol Res2001，7，： | 1 |
| 19 | Strategic Implementation as a Core Competency: The5P' s Model 显示文摘 | MILDRED G P DONNA A LESLIE A T JOHN H H | 2007 | Jour- nal of Management Research2007，，7： | 1 |
| 20 | Developments and Chal- lenges in the Utilization of Magnesium Alloys 显示文摘 | Dahle A K John D H Dunlop G L | 2000 | Mater Forum2000，，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员