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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | The grapevine guard cell-related VvMYB60 transcription factor is in- volved in the regulation of stomatal aetivity and is differ- entially expressed in response to ABA and osmotic stress 显示文摘 | Massimo G Jose T M Prisilla F | 2011 | BioMed Central Plant Biology2011，11，： | 1 |
| 4 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 5 | Effect of pore size and aluminium content on the production of linear alkylbenzenes over HY, H-ZSM-5 and H-ZSM-12 zeolites; alkylation of benzene with 1-dodecene显示文摘 | Dufaux M Younes B T | 1994 | Appl Catal A: General1994，114，： | 1 |
| 6 | Calculation of electric field and potential distributions into soil and air media for a ground electrode of a HVDC system显示文摘 | Jose E T V Carlos M P | 2003 | IEEE Transactions on Power Delivery2003，18，3： | 1 |
| 7 | N-acyl-L-homoserine lactones: a class of bacterial quorum-sensing signals alter post-embryonic root de- velopment in Arabidopsis thaliana 显示文摘 | Randy O C Mignel M T Jose L B | 2008 | Plant Cell Environ2008，31，： | 1 |
| 8 | Comparison of two methods for anteriorposterior isocenter localization in pelvic radiotherapy using electronic portal imaging显示文摘 | Greer P B Mortensen T M Jose C C | 1998 | Int J Radiat Oncol Biol Phys1998，41，： | 1 |
| 9 | A new TwIST: two-step iterative shrinkage/thresholding algorithms for image restoration显示文摘 | Jose M Bioucas-Dias Mario A T Figueiredo | 2007 | IEEE Transactions on Image Processing2007，16，12： | 1 |
| 10 | Improved technique for estimation of preconsolidation pressure显示文摘 | SRIDHARAN A ABRAHAM B M JOSE B T | 1991 | Geoteehnique1991，41，2： | 1 |
| 11 | Multiresidue analysis of quinolones and fluoroquinolones in soil by ultrasonic - assisted extraction in small colunms and HPLC - UV显示文摘 | ESTHER T ANTONIO M E JOSE L T | 2006 | Analytica Chimica Acta2006，562，： | 1 |
| 12 | Trace Analysis of Seven Neonicotinoid Insecticides in Bee Pollen by Solid-liquid Extraction and Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry显示文摘 | KAREN P Y MARIA T M JOSE L B | 2014 | Food Analytical Methods2014，7，2： | 1 |
| 13 | A new thermostimulated luminescence phosphor based on CaSO4:Ag,Tm for applications in radiation dosimetry 显示文摘 | MADHUSOODANAN U JOSE M T TOMITA A | 1999 | 82:221-2321999，82，： | 1 |
| 14 | Improved technique for estimation of preconsolidation pressure显示文摘 | SRIDHARAN A ABRAHAM B M JOSE B T | 1991 | Geotechnique1991，41，2： | 1 |
| 15 | Surface heat transfer coefficients for refrigeration and freezing of foods immersed in an ice slurry显示文摘 | GONZALO T M JOSE A ANA C | | 0，，07： | 1 |
| 16 | A tabu search algorithm for large-scale guillotine (un)constrained two- dimensional cutting problems显示文摘 | Ramdn A V Antonio P Jose'e M T | 2002 | Computers &: Operations Research2002，，29： | 1 |
| 17 | Complete congenital foetal heart block: a case report 显示文摘 | DEY M JOSE T SHRIVASTAVA A | 2014 | Facts Views Vis Obgyn2014，6，1： | 1 |
| 18 | Molecular imprinting-based separation methods for selective analysis of fluoroquinolones in soils显示文摘 | ESTHER T ANTONIO M E JOSE L T | 2007 | J Chromatogr A2007，1172，2： | 1 |
| 19 | Protoplast formation and regeneration from Streptomyces clavuligerus NRRL 3585 and elavulanie acid production 显示文摘 | Maria das G C Jose L L F Galba M C T | 2002 | Brazilian Journal of Microbiology2002，33，： | 1 |
| 20 | Fast image recovery using variable splitting and con- strained optimization 显示文摘 | Manya V Afonso Jose M Bioucas-Dias Mario A T Figueire- do | 2010 | IEEE Transactions on Image Pro- cessing2010，19，9： | 1 |
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