| 1 | Basic and clinical aspects of osteoporosis in inflammatory bowel disease显示文摘低骨头矿物质密度和在胃肠的疾病的骨折的增加的风险有多因素的致病。煽动性的肠疾病(IBD ) 与骨质疏松症和 osteopenia 的增加的风险被联系了,流行病的研究与 IBD 在病人报导了低骨头质量的增加的流行。当然,遗传玩一个重要角色与象全身的发炎那样的另外的因素一起,营养不良,性腺机能减退,在 IBD 的糖皮质激素治疗和另外的生活方式因素。在分子的水平职业人员煽动性的 cytokines 在 IBD 贡献肠的有免疫力的反应被知道提高骨吸收。有基因,影响造骨细胞功能, LRP5 可以涉及骨胳的发展,是可能的。另外,维生素D受体(VDR ) 和一些它的多型性的鉴定导致了考虑在他们和一些自体免疫的疾病之间的可能的关系并且可以通过它的免疫的努力涉及致病调节效果在发炎期间。试着解释我们发现了那的病理生理学为在全身的发炎之间的集成正在增加证据,骨头损失多半为激活的原子因素经由受体调停 kappa-B (等级) , RANK-ligand,和 osteoprotegerin,能影响 osteoclastogenesis 和 T 房间激活的蛋白质。尽管 glucocorticoids 能减少粘膜和全身的发炎,他们有否定地影响骨头质量的内在的质量。如果所有 IBD 病人应该被屏蔽,它仍然是争论的,特别在有先存在的病人为骨头疾病的风险因素。测量 BMD 的可得到的方法包括单个精力 X 光 absorptiometry, DXA,量的计算断层摄影术(QCT ) , X 光线照相术的 absorptiometry,和超声。DXA 是 establish 方法决定 BMD,并且习惯性地在臀部和腰椎被测量。有几种治疗选择,证明了他们的有效性,当象在其它之中的 calcitonin 和 teriparatide 那样的新突现的治疗尚待被评定时。 | Lorena Rodríguez-Bores JosuéBarahona-Garrido Jesús K Yamamoto-Furusho | 2007 | World Journal of Gastroenterology2007，13，46： | 5 |
| 2 | Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients显示文摘AIM: To evaluate the factors that influence outcome of both non-invasive and invasive treatment of polycystic liver disease. METHODS: Analysis of clinical files of patients with complete follow-up from July 1986 to June 2006. RESULTS: Forty-one patients (male, 7; female, 34), 47.8 ± 11.9 years age, and 5.7 ± 6.7 years follow-up, were studied. Alkaline phosphatase (AP) elevation (15% of patients) was associated with the requirement of invasive treatment (IT, P = 0.005). IT rate was higher in symptomatic than non-symptomatic patients (65.4% vs 14.3%, P = 0.002), and in women taking hormonal replacement therapy (HRT) (P = 0.001). Cysts complications (CC) were more frequent (22%) in the symptomatic patients group (P = 0.023). Patients with body mass index (BMI) > 25 (59%) had a trend to complications after IT (P = 0.075). Abdominal pain was the most common symptom (56%) and indication for IT (78%). Nineteen patients (46%) required a first IT: 12 open fenestration (OF), 4 laparoscopic fenestration (LF) and 3 fenestration with hepatic resection (FHR). Three required a second IT, and one required a third procedure. Complications due to first IT were found in 32% (OF 16.7%, LF 25%, FHR 66.7%), and in thesecond IT in 66.7% (OF 100%). Follow-up mortality rate was 0. CONCLUSION: Presence of symptoms, elevated AP, and CC are associated with IT requirement. HRT is associated with presence of symptoms and IT requirement. Patients with BMI > 25 have a trend be susceptible to IT complications. The proportions of complications are higher in FHR and second IT groups. RS is more frequent after OF. | Josué Barahona-Garrido Jesús Camacho-Escobedo Eduardo Cerda-Contreras Jorge Hernández-Calleros Jesús K Yamamoto-Furusho Aldo Torre Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，20： | 4 |
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