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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Immediate argon laser peripheral iridoplasty as treatment for acute attack of PACG: a preliminary study 显示文摘 | Lam DSC Lai JSM Tham CC | 1998 | Ophthalmology1998，105，12： | 1 |
| 3 | Human herpesvirus 6 and 7 DNA in peripheral blood leukocytes and plasma in patients with pityriasis rosea by polymerase chain reaction - a prospective case control study显示文摘 | Chiu SSS Peiris JSM | 2001 | Acta Derm Venereol2001，81，： | 1 |
| 4 | Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle closure glaucoma 显示文摘 | Lam DSC Lai JSM Tham CC etal | 2002 | Ophthalmology2002，109，9： | 1 |
| 5 | Arogon laster peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma显示文摘 | Lam DSC Lai JSM Tham CCY | 2002 | Ophthalmology2002，109，6： | 1 |
| 6 | Clinical progression and viral load in a comnunity outbreak of coronavirus-associated SARS pneumonia: a prospective study显示文摘 | Peiris JSM Chu C M Cheng VCC | 2003 | Lancet2003，361，： | 1 |
| 7 | Immediate laser iridoplasty without topical or systemic medications and with subsequent iridotomy for treating acute angle closuer glaucoma显示文摘 | Tham CCY Lai JSM Lam DSC | 1999 | Ophthalmology1999，106，： | 1 |
| 8 | Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection 显示文摘 | Bern RA Woensel JSM Bos AP | 2009 | Am J Physiol Lung Cell Mol Physiol2009，296，1： | 1 |
| 9 | Immediate argon laser peripheral iridophasty as treatment for acute attack of primary angle - closure glaucoma: a preliminary study 显示文摘 | Lai JSM Tham CCY | 1998 | Ophthalmology1998，105，： | 1 |
| 10 | Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study显示文摘 | JSM Peiris CM Chu VCC Cheng | 2003 | Lancet2003，361，： | 1 |
| 11 | Efficacy and safety of the Ahmed glaucoma valve implant in Chinese eyes with complicated glaucoma显示文摘 | Lai JSM Poon ASY Chua JKH | | 0，，07： | 1 |
| 12 | Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle - closure glaucoma显示文摘 | Lai JSM Tham CCY | 2002 | Ophthalmology2002，109，： | 1 |
| 13 | Immediate argon laser peripheral iridoplasty as treatment for acute attack of primary angle-closure glaucoma:a preliminary study显示文摘 | Lam DSC Lai JSM Tham CCY | 1998 | Ophthalmology1998，105，12： | 1 |
| 14 | Coronavirus as a possible cause of severe acute respiratory syndrome 显示文摘 | Peiris JSM Lai ST Poon LLM | 2003 | Lancet2003，361，9366： | 1 |
| 15 | Immediate argon laser peripheral iridoplasty for acute attack of PACG( addendum to previous report) 显示文摘 | Tham CCY Lai JSM Lam DSC | 1999 | Ophthalmology1999，106，6： | 1 |
| 16 | Clinical pro-gression and viral load in a community outbreak of corona vir-us-associated SARS pneumonia: a prospective study显示文摘 | PEIRIS JSM CHU CM CHENG VCC | 2003 | TheLancet2003，36，1： | 1 |
| 17 | Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of actue primary angle-closure glaucoma:a prospective,randomized,controlled trial 显示文摘 | Lam DSC Lai JSM Tham CCY | 2002 | Ophthamology2002，109，9： | 1 |
| 18 | Expression of the Corynebacterium glutamicum panD Gene Encoding L-Aspartate-a- Decarboxylase Leads to Pantothenate Overproduction in Escherichia coli显示文摘 | Nicole D Alfred P Jsm K | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 19 | Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays显示文摘 | Poon Leo LM Chan KH Smith GJ Leung CSW Guan Y Yuen KY Peiris JSM | 2009 | Clin Chem2009，55，8： | 1 |
| 20 | Coronavirus as possible cause of severe acute respiratory syndrome 显示文摘 | Peiris JSM Lai ST Poon LLM | 2003 | Lancet2003，261，： | 1 |
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