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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 3 | Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: A multicenter prospective study (the FIBROSTIC study)显示文摘 | Francoise Degos Paul Perez Bruno Roche Amel Mahmoudi Julien Asselineau Hélène Voitot Pierre Bedossa | 2010 | Journal of Hepatology2010，，6： | 3 |
| 4 | Liver Fibrosis: Noninvasive Assessment with Acoustic Radiation Force Impulse Elastography—Comparison with FibroScan M and XL Probes and FibroTest in Patients with Chronic Liver Disease显示文摘 | Christophe Cassinotto Bruno Lapuyade Ania A?t-Ali Julien Vergniol Delphine Gaye Juliette Foucher Claire Bailacq-Auder Faiza Chermak Brigitte Le Bail Victor de Lédinghen | 2013 | Radiology2013，，1： | 3 |
| 5 | Controlled Attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5,323 examinations显示文摘 | Victor de Lédinghen Julien Vergniol Maylis Capdepont Faiza Chermak Jean-Baptiste Hiriart Christophe Cassinotto Wassil Merrouche Juliette Foucher Brigitte Le Bail | 2013 | Journal of Hepatology2013，，： | 3 |
| 6 | Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations显示文摘 | Juliette Foucher Laurent Castéra Pierre-Henri Bernard Xavier Adhoute David Laharie Julien Bertet Patrice Couzigou Victor de Lédinghen | 2006 | European Journal of Gastroenterology & Hepatology2006，，4： | 3 |
| 7 | Two-dimen sional simulations of extreme floods on a large watershed显示文摘 | ENGLAND J F VELLEUX M L JULIEN P Y | 2007 | Journal of Hydrology2007，347，： | 1 |
| 8 | TREX:Spa- tially distributed model to assess watershed contaminant transport and fate 显示文摘 | VELLEUX M L ENGLAND J F JULIEN P Y | 2008 | Science of the Total Environment2008，404，： | 1 |
| 9 | Prevalence of coronary atherosclerosis in patients with cerebral infarction显示文摘 | Pierre A Lavallee PC Julien L | 2011 | Stroke2011，42，1： | 1 |
| 10 | Implementation of food safety management systems in the UK 显示文摘 | Mensah L D Julien D | 2011 | Food Control2011，22，8： | 1 |
| 11 | Types of tech- nological scanning in manufacturing SMEs: an empirical analy- sis of patterns and determinants 显示文摘 | JULIEN P A RAYMOND L JACOB R | 1999 | Entrepreneurship & Re- gional Development1999，11，4： | 1 |
| 12 | Impact of plant essential oils on microbiological, organoleptie and quality markets of minimally processed vegetables 显示文摘 | Jorge G Paula B Julien L | 2009 | Innovative Food Science and Emerging Technologies2009，10，2： | 1 |
| 13 | Trends in information behavior research,1999-2008:A content analysis显示文摘 | Julien H Pecoskie J L Reed K | 2011 | LIBRARY & INFORMATION SCIENCE RESEARCH2011，33，1： | 1 |
| 14 | Communicating research findings to library and information science practitioners: a study of IS1C papers from 1996 to 2000显示文摘 | MCKECHNIE L JULIEN H GENUIS S K | 2008 | Information Research2008，13，4： | 1 |
| 15 | Fabrication of LiCoO2 Thin-film Cathodes for Rechargeable Lithium Mierobatteries显示文摘 | Julien C Camacho-Lopez M A Escobar-Alarcon L | 2001 | Materials Chemistry and Physic:2001，68，： | 1 |
| 16 | Reduction of hos pital utilization in patients with chronic obstructive pul monarydisease: A disease-specific self-management in tervention显示文摘 | Bourbeau J Julien M Maltais F et a l | 2003 | Arch Intern Med2003，163，5： | 1 |
| 17 | Adverse associations between CX3CR1 polymorphisms and risk of cardiovascular or cerebrovascular disease显示文摘 | Elise L Julien L Mehdi D | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 18 | Biopolymer immobilization during the crystalline growth of layered double hydroxide显示文摘 | FABRICE L JULIEN G BESSE J P | 2004 | J Solid State Chem2004，177，： | 1 |
| 19 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 1 |
| 20 | Intracranial arterial dolichoectasia and small-vessel disease in stroke patients显示文摘 | Fernando P Julien L Pierre Jean T | 2005 | Ann Neurol2005，57，： | 1 |
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