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| 1 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 2 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 3 | Relation of Mineralizable N to Organic N Components in Dark Loessial Soils显示文摘Mineralizable N and organic N components in different layers (0~15, 15~30, 30~45, 45~60, 60~80 and80~100 em) of six soils with different fertilities sampled from Yongshou County, Shaanxi Province, China,were determined by the aerobic incubation method and the Bremner procedure, respectively. Correlation,multiple regression and path analyses were performed to study the relation of mineralizable N to organic Ncomponents. Results of correlation and regression analyses showed that the amounts of the N mineralizedwere parallel to, and significantly correlated with, the total acid hydrolyzable N, but was not so with the acid-insoluble N. Of the hydrolyzable N, the amino acid N and the ammonia N had a highly consistent significantcorrelation with the mineralized N, and their partial regression coefficients were significant in the regressionequations, showing their importance in contribution to the mineralizable N. The amino sugar N, on the otherhand, had a relatively high correlation with the mineralized N, but their partial regression coefficients werenot significant in the regression equations. In contrast, the hydrolyzable unknown N had no such relations.Path analysis further indicated that the amino acid N and ammonia N made great direct contributions tothe mineralized N, but the contributions of the amino sugar N were very low. These strongly suggested thatthe mineralized N in the soils tested was mainly from the hydrolyzable N, particularly the amino acid N andammonia N which are the major sources for its production. | LI JUMEI and LI SHENGXIUCollege of Natural Resources and Environmental Sciences, Northwestern Science and Technology University of Agriculture and Forestry, Yangling, Shaanxi 712100 (China) | 2003 | Pedosphere2003，13，3： | 4 |
| 4 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 5 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 6 | Quercetin inhibits the proliferation of multiple myeloma cells by upregulating PTPRR expression显示文摘Multiple myeloma (MM) is an incurable disease characterized by malignant plasma cell clonal expansion in the bone marrow;therefore, inhibiting the proliferation of plasma cells is an important approach to overcome the progression of MM. Quercetin (Que) is a promising flavonoid with broad-spectrum anti-tumor activity against various cancers, including MM;however, the underlying mechanism is not yet understood. The present study aimed to reveal the gene expression profile of Que-treated MM cells and clarify its potential mechanism. The 30% inhibitory concentration (IC30) of Que against MM cells was calculated, and the proliferation rate was significantly reduced after Que treatment. Next, 495 dysregulated genes were identified via RNA sequencing in Que-treated MM cells. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses indicated that the dysregulated genes were enriched in various apoptosis-related GO terms and amino acid metabolism-related pathways. qPCR validation showed that protein tyrosine phosphatase receptor-type R (PTPRR) had the highest verified log2 FC (abs) among the top 15 dysregulated genes. Overexpression of PTPRR increased the sensitivity of MM cells against Que, significantly inhibiting their proliferation and colony formation ability;silencing of PTPRR showed the opposite results. Furthermore, bioinformatics analyses and PPI network construction of PTPRR indicated that dephosphorylation of ERK might be the potential pathway for the PTPRR-induced inhibition of MM cell proliferation. In summary, our study identified the gene expression profile in Que-treated MM cells and demonstrated that the upregulation of PTPRR was one of the important mechanisms for the Que-induced inhibition of MM cell proliferation. | Houcai Wang Dandan Yu Hui Zhang Ruye Ma Huiqun Wu Huili Zhai Huaping Wang Jingjing Li Liping Li Yingcong Wang Taofang Cheng Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 2 |
| 7 | Hyperthermia by a nitinol stent in an alternating magnetic field:Safety and feasibility in rabbit esophageal cancer显示文摘Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer.This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field(AMF) and investigated whether this method offers a therapeutic option for esophageal cancer.Nitinol stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50℃.The esophagi were histologically examined after a week to observe whether there was transmural necroses.Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃for 10 min.Stents were heated to a target temperature within 5 min.The highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃for 10 min.Tumor growth was delayed by heating and it was statistically significant.Heating the rabbit esophageal wall at 46℃for 10 min proves to be safe and effective in delaying tumor growth. | Jumei Zhou Ning Li Qisheng Xia Lehui Du Xiaowen Wang Linyun Zhao Xufei Wang Jintian Tang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 8 | Enhanced electrochemical performance and mechanism study of AgLi1/3Sn2/3O2 for lithium storage显示文摘Herein,AgLi1/3Sn2/3O2 with delafossite structure was prepared by treating the layered compound Li2 SnO3 with molten AgN03 via ion exchange of Li^+for Ag^+.The structure characterization and the electrochemical performance of AgLi1/3Sn2/3O2 was thoroughly investigated.AgLi1/3Sn2/3O2 is found to possess stacking lamellar morphology,which means small electrochemical impedance and so facilitates charge transfer kinetics during the cycling.Compared with Li2 Sn03,due to the introducing of excellent electrical conductivity of silver,AgLi1/3Sn2/3O2 exhibits improved electrochemical performance in terms of capacity,cycling stability and coulombic efficiency.The results show AgLi1/3Sn2/3O2 presents favorable specific capacity of 339 mAh/g at current density of 200 mA/g after 50 cycles and initial coulombic efficiency of 96%.Exsitu XRD analysis revealed the reaction mechanism of AgLi1/3Sn2/3O2 as an anode for lithium ion batteries. | Fan Lu Jie Yang Ling Zhou Xinyue Wang Yin Yang Jumei Li | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 9 | Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。 | Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 10 | Effects of rape straw and red mud on extractability and bioavailability of cadmium in a calcareous soil显示文摘划算的土壤修正案屏蔽是重要的在 situ 补习技术发展因为镉(Cd ) 污染了土壤。在这研究,不同土壤修正案包括红泥,氧化铝工业的一个副产品,并且酸处理,由 nanoparticle milling , nano 和酸处理的红 对待nano 泥,沸石,玉米稻草,和强奸稻草,被评估在二个增加的层次使 Cd 不能调动( 2 和 5 mg Cd 敲漠?業牣?汥'虪箾K獹獩爠慥瑣牯?桷捩?湩楤慣整?牧慥?潰整瑮慩?潦?桴?牰捡楴慣?灡汰捩瑡潩?景琠敨挠牥浡捩?湩琠敨映敩摬漠?捡畴污椠摮獵牴慩? | Junxing YANG Liqun WANG Jumei LI Dongpu WEI Shibao CHEN Qingjun GUO Yibing MA | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 1 |
| 11 | Textured BaTi2O5 ceramic synthesized by laser rapid solidification method and its dielectric properties显示文摘 | Junji Zhang Jumei Yu Mingju Chao Erjun Liang Mingyu Li Dechuan Li | 2012 | Journal of Materials Science2012，，3： | 1 |
| 12 | Major controlling factors and predictions for cadmium transfer from the soil into spinach plants显示文摘 | Zhenfei Liang Qiong Ding Dongpu Wei Jumei Li Shibao Chen Yibing Ma | 2013 | Ecotoxicology and Environmental Safety2013，，： | 1 |
| 13 | Polyolefi n-Coated Urea Decreases Ammonia Volatilization in a Double Rice System of Southern China显示文摘 | Xu Minggang Li Dongchu Li Jumei Qin Daozhu Hosen Yasukazu Shen Huaping Cong Rihuan He Xinhua | 2013 | Agronomy Journal2013，，1： | 1 |
| 14 | Phosphorus accu-mulation and depletion in soils in wheat-maize cropping systems:Modeling and validation显示文摘 | Yibing Ma Jumei Li Xiuying Li | 2009 | Field Crops Research2009，110，： | 1 |
| 15 | DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma显示文摘 | Wenqin Xiao Bo Li Xi Sun Dandan Yu Yongsheng Xie Huiqun Wu Shuaikang Chang Yunfei Zhou Houcai Wang Xiucai Lan Zhijian Xu Jumei Shi Weiliang Zhu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 1 |
| 16 | Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo:involvement of the PI3K‒AKT‒mTOR/JNK pathway显示文摘Diffuse large B-cell lymphoma(DLBCL)is the most common type of non-Hodgkin lymphoma,characterized by high heterogeneity.The poor outcome of a portion of patients who suffer relapsing or resistant to conventional treatment impels the development of novel agents for DLBCL.DCZ0825 is a novel compound derived from pterostilbene and osalmide,whose antitumor activities have drawn our attention.In this study,we found that DCZ0825 exhibited high cytotoxicity toward DLBCL cell lines in a dose-and time-dependent manner,as revealed by cell counting kit-8 assay.Flow cytometry and western blot analysis results showed that DCZ0825 also promoted cell apoptosis via both extrinsic and intrinsic apoptosis pathways mediated by caspase.In addition,DCZ0825 induced cell cycle arrest in the G2/M phase by downregulating Cdc25C,CDK1,and Cyclin B1,thus interfering with cell proliferation.Further investigation showed the involvement of the phosphatidylinositol 3-kinase(PI3K)‒AKT‒mTOR/JNK pathway in the efficacy of DCZ0825 against DLBCL.Remarkably,DCZ0825 also exerted notable cytotoxic effects in vivo as well,with low toxicity to important internal organs such as the liver and kidney.Our results suggest that DCZ0825 may have the potential to become a novel anti-DLBCL agent or to replenish the conventional therapeutic scheme of DLBCL. | Ke Hu Bo Li Ruye Ma Hongfei Yi Zhijian Xu Yu Peng Dandan Yu Huiqun Wu Taofang Cheng Yumeng Lu Yong Zhang Rong Wei Guang Yang Xiaosong Wu Weiliang Zhu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 17 | Prevalence, molecular characterization, and antibiotic susceptibility of Cronobacter spp. in Chinese ready-to-eat foods显示文摘 | Xiaoke Xu Chengsi Li Qingping Wu Jumei Zhang Jiahui Huang Guangzhu Yang | 2015 | International Journal of Food Microbiology2015，，： | 1 |
| 18 | Phospholus Efficiency in Long-Term (15 Years) Wheat- Maize Cropping Systems with Various Soil and Climat Conditions 显示文摘 | XU TANG JUMEI LI YIBING MA | 2008 | Field Crops Research2008，，108： | 1 |
| 19 | Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation显示文摘 | Jumei Shi Junru Wang Huaien Zheng Wen Ling Jacob Joseph Dayuan Li Jawahar L Mehta Usha Ponnappan Pei Lin Louis M Fink Martin Hauer-Jensen | 2003 | Blood Coagulation & Fibrinolysis2003，，6： | 1 |
| 20 | Survey on applications of algebraic state space theory of logical systems to finite state machines显示文摘Algebraic state space theory(ASST)of logical systems,developed based on the semi-tensor product(STP)which is a new matrix analysis tool built in recent ten years,provides an algebraic analysis approach for many fields of science,such as logical dynamical systems,finite-valued systems,discrete event dynamic systems,and networked game systems.This study focuses on comprehensively surveying the applications of the ASST method to the field of finite state machines(FSMs).Some necessary preliminaries on the method are first reviewed.Then the applications of the method in the FSM field are reviewed,including deterministic FSMs,nondeterministic FSMs,probabilistic FSMs,networked FSMs,and controlled and combined FSMs.In addition,other applications related to both STP and FSMs are surveyed,such as the application of FSM to Boolean control networks and the application of graph theory to FSMs.Finally,some potential research directions with respect to the ASST method in the FSM field are predicted. | Yongyi YAN Daizhan CHENG Jun-E FENG Haitao LI Jumei YUE | 2023 | Science China(Information Sciences)2023，66，1： | 1 |
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