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| 1 | Differential Effect of Artemisinin Against Cancer Cell Lines显示文摘The present study aims at defining the differential cytotoxicity effect of artemisinin toward P815(murin mastocytoma)and BSR(kidney adenocarcinoma of hamster)cell lines.Cytotoxicity was measured by the growth inhibition using MTT assay.These in vitro cytotoxicity studies were complemented by the determination of apoptotic DNA fragmentation and Annexin V-streptavidin-FITC assay.Furthermore,we examined the in vitro synergism between artemisinin and the chemotherapeutic drug,vincristin.The in vivo study was investigated using the DBA2/P815(H2d)mouse model.While artemisinin acted on both tumor cell lines,P815 was much more sensitive to this drug than BSR cells,as revealed by the respective IC50 values(12 lM for P815 and 52 lM for BSR cells).On another hand,and interestingly,apoptosis was induced in P815 but not induced in BSR.These data,reveal an interesting differential cytotoxic effect,suggesting the existence of different molecular interactions between artemisinin and the studied cell lines.In vivo,our results clearly showed that the oral administration of artemisinin inhibited solid tumor development.Our study demonstrates that artemisinin caused differential cytotoxic effects depending not only on the concentration and time of exposure but also on the target cells. | Mounir Tilaoui Hassan Ait Mouse Abdeslam Jaafari Abdelmajid Zyad | 2014 | Natural Products and Bioprospecting2014，4，3： | 8 |
| 2 | Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study显示文摘Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease. | Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud | 2019 | Neural Regeneration Research2019，14，4： | 6 |
| 3 | Deep learning neural networks for spatially explicit prediction of flash flood probability显示文摘Flood probability maps are essential for a range of applications,including land use planning and developing mitigation strategies and early warning systems.This study describes the potential application of two architectures of deep learning neural networks,namely convolutional neural networks(CNN)and recurrent neural networks(RNN),for spatially explicit prediction and mapping of flash flood probability.To develop and validate the predictive models,a geospatial database that contained records for the historical flood events and geo-environmental characteristics of the Golestan Province in northern Iran was constructed.The step-wise weight assessment ratio analysis(SWARA)was employed to investigate the spatial interplay between floods and different influencing factors.The CNN and RNN models were trained using the SWARA weights and validated using the receiver operating characteristics technique.The results showed that the CNN model(AUC=0.832,RMSE=0.144)performed slightly better than the RNN model(AUC=0.814,RMSE=0.181)in predicting future floods.Further,these models demonstrated an improved prediction of floods compared to previous studies that used different models in the same study area.This study showed that the spatially explicit deep learning neural network models are successful in capturing the heterogeneity of spatial patterns of flood probability in the Golestan Province,and the resulting probability maps can be used for the development of mitigation plans in response to the future floods.The general policy implication of our study suggests that design,implementation,and verification of flood early warning systems should be directed to approximately 40%of the land area characterized by high and very susceptibility to flooding. | Mahdi Panahi Abolfazl Jaafari Ataollah Shirzadi Himan Shahabi Omid Rahmati Ebrahim Omidvar Saro Lee Dieu Tien Bui | 2021 | Geoscience Frontiers2021，12，3： | 4 |
| 4 | Subthalamic nucleus stimulation in severe obsessive--compulsive disorder显示文摘 | Mallet L Polosan M Jaafari N | 2008 | N Engl J Med2008，359，20： | 1 |
| 5 | Management of risks: uncertainties and opportunities on projets: time for a fundamental shift 显示文摘 | ALI JAAFARI | 2001 | International Journal Of Project Management2001，10，2： | 1 |
| 6 | Simulation of afixed bed adsorber packed with protonated cross-linked chitsan gel beads to removal nitrate from contaminated water 显示文摘 | JAAFARI K RUIZT ELMALEHS | 2004 | Chemical Engineering Journal2004，99，： | 1 |
| 7 | The effect of combined decongestive therapy and pneumatic compression pump on lymphedema indicators in patients with breast cancer related lymphedema显示文摘 | Moattari M Jaafari B Talei A | | 0，，04： | 1 |
| 8 | Management of Risks, Uncertainties and Opportunities on Projects: Time for a Fundamental Shift 显示文摘 | Jaafari A | 2001 | International Jour- nal of Project Management2001，19，2： | 1 |
| 9 | Concurrent Construction and life cycle project management显示文摘 | A Jaafari | 1997 | Journal of Construction Engineering and Management1997，123，4： | 1 |
| 10 | Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones显示文摘 | Cimarosti H Ashikaga E Jaafari N | 2012 | J Cereb Blood Flow Metab2012，32，1： | 1 |
| 11 | Management of risks, uncertainties and opportunities on projects: time for a fundamental shift显示文摘 | Ali Jaafari | 2001 | International Journal of Project Management2001，，2： | 1 |
| 12 | Knowledge about HIV infection and attitude of nursing staff toward patients with AIDS in Iran显示文摘 | Askarian M Heshemi Z Jaafari P | 2006 | Infection Control and Hospital Epidemiology2006，27，1： | 1 |
| 13 | Obsessive compulsive disorder in a patient with twiddler' s syndrome 显示文摘 | Jaafari N Bachollet MS Paillot C | 2009 | Pacing Clin Electrophysiol2009，32，3： | 1 |
| 14 | Bioelectricity generation using two chamber microbial fuel cell treating wastewater from food processing显示文摘 | Mansoorian H J Mahvi A H Jaafari A J | 2013 | Enzyme and Microbial Technology2013，52，67： | 1 |
| 15 | Optimization of a method toprepare liposomes containing HER2/Neu - derived peptide as avaccine delivery system for breast cancer显示文摘 | Shariat S Badiee A’Jaafari MR | 2014 | Iran J Pharm Res2014，，： | 1 |
| 16 | Management of risks, uncertainties and opportu- nities on projects: time for a fundamental shift 显示文摘 | Jaafari A | 2001 | Inter- national journal of project management2001，19，2： | 1 |
| 17 | Investigation of the various structure parameters for predicting impact sensitivity of en- ergetic molecules via artificial neural network显示文摘 | Keshavarz M H Jaafari M | 2006 | Propellants Explosives Pyrotechnics2006，31，3： | 1 |
| 18 | Comparative relation ship of the flag leaf and the ear photosynthesis with the bio mass and grain yield of durum wheat under a range of water conditions and different ecotypes显示文摘 | Abbad H El Jaafari S A Bort J | 2004 | Agronomic2004，24，： | 1 |
| 19 | Synthesis of a model for lifecycle project management 显示文摘 | JAAFARI A MANIVONG K | 2000 | Computer-Aided Civil and Infrastructure Engineering2000，15，1： | 1 |
| 20 | Towards a smart project management information system 显示文摘 | JAAFARI A MANIVONG K | 1998 | International Journal of Project Management1998，16，4： | 1 |
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