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| 1 | 利用AFLP进行“甘蔗属复合体”系统演化和亲缘关系研究显示文摘采用AFLP分子标记技术,对“甘蔗属复合体”中4个属16个种的6 9份来自中国和澳大利亚的甘蔗种质资源材料进行系统演化和亲缘关系分析。2对AFLP引物共检测到173个标记,其中172个为多态标记,多态率达99 4 % ;通过计算Jaccard相似性系数,用UPGMA和PCA法构建了分子系统树和效应图。结果表明:(1)属间亲缘关系中,甘蔗属与芒属较近,与河八王属和蔗茅属较远,而河八王属与蔗茅属较近;(2 )甘蔗属内,细茎野生种与其他种关系较远,其中,栽培品种与热带种关系较近,中国种和印度种关系较近,而大茎野生种自聚为一族,与上述4种分离;(3)蔗茅属内,除蔗茅种和滇蔗茅种外,无论是中国斑茅(云南、海南)还是印度尼西亚斑茅,都与蔗茅属其他种聚在一起,其中与E procerus的关系最近,与E bengalense和E sarpet种次之;由斑茅与这3个种构成的群体与由E elephantinus和E ravennae构成的群体相对分离,形成了明显的2个组群。再次表明斑茅应列入蔗茅属,建议我国甘蔗学者采纳国外分类命名(E arundinaceus) ,以能更好地开展斑茅的研究和杂交育种利用并与国际接轨;(4)蔗茅和滇蔗茅均没有聚类到蔗茅属类群中,而分别独立位于系统树2大枝系上。蔗茅与甘蔗属亲缘关系较近,与芒属亲缘关系次之,与蔗茅属和河八王属关系较远;滇蔗茅与河八王属亲缘关系? | 蔡青 范源洪 Aitken K Piperidis G McIntyre C L Jackson P | 2005 | 作物学报2005，31，5： | 33 |
| 2 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 3 | 孤立性骨骼浆细胞瘤和孤立性髓外浆细胞瘤的诊断和处理指南显示文摘许多患有浆细胞肿瘤的患者就诊时表现为全身性疾病,如多发性骨髓瘤(MM),而少数患者(<5%)表现为由单克隆性浆细胞增殖所致孤立性骨骼浆细胞瘤(SBP)引起的单一性骨损伤,或者较少见的孤立性髓外浆细胞瘤(SEP)引起的软组织肿块.SBP有进展为MM的高风险性,核磁共振成像(MRI)检查在至少25%伴有明显孤立性损害的患者中发现身体的其他部位有该疾病的证据.相反,SEP几乎总是局限性的,局部治疗有很高的治愈率. | Soutar R Lucraft H Jackson G 刘淑艳 薛永权 | 2005 | 国外医学(输血及血液学分册)2005，28，4： | 8 |
| 4 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 5 | APSIM-Sugar模型在云南半湿润半干旱蔗区的适应性研究显示文摘【目的】本研究对APSIM-Sugar模型在云南半湿润半干旱蔗区的适应性进行评价。【方法】从研究地区2个代表站点甘蔗大田试验获取调参验证数据集,基于标准品种Q117模型参数,采用试错法对8个关键品种参数进行优化和模拟精度评价。【结果】确定了Q208和ROC22两个甘蔗新品种的模型参数优化值,评估了模型在云南蔗区的产量糖分模拟误差范围。结果显示蔗糖产量实测值与模型模拟值显著相关,绝对误差小于2 t/hm^2,斜率在0. 8~1. 26,R^2大于0. 8。【结论】经过校验的APSIM-Sugar模型能较好模拟云南半湿润半干旱蔗区甘蔗的生长发育过程,并响应环境变化造成的产量和糖分差异,但是在多年宿根和极端环境条件下的模拟精度仍有待提高。模型品种参数和输入数据的不确定性是造成模型模拟结果不确定性的重要原因。 | 毛钧 Inman-Bamber N G 陆鑫 Jackson P A 王靖 刘家勇 范源洪 | 2018 | 西南农业学报2018，31，12： | 4 |
| 6 | Evidence for two rhabdoviruses in taro ( Colocasia esculenta) in the Pacific region显示文摘 | Pearson M N Jackson G V H Saelea J | 1999 | Austral Plant Pathol1999，28，3： | 2 |
| 7 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 8 | Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants 显示文摘 | Middleton PG Taylor PR Jackson G | 1998 | Blood1998，92，10： | 1 |
| 9 | Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma显示文摘 | STRAUME O JACKSON D G AKSLEN L A | 2003 | Clin Cancer Res2003，9，： | 1 |
| 10 | Treatment of functional gastrointestinal disorders with antidepressant medications : a meta-analysis 显示文摘 | JACKSON JL MALLEY PG TOMKINS G | 2000 | Am J Med2000，108，1： | 1 |
| 11 | A Hierarchical Model of Leisure Constraints 显示文摘 | CRAWFORD D W JACKSON E L GODBEY G | 1991 | Leisure Sciences1991，13，： | 1 |
| 12 | A multicenter, open, non-comparative phase Ⅱ study of a combination of fludarabine phosphate,cytarabine and granulocyte colonystimulating factor in relapsed and refractory acute myeloid leukemia and de novo refractory anemia with excess of blasts in transformation 显示文摘 | Jackson G Taylor P Smith GM | 2001 | Br J Haematol2001，112，1： | 1 |
| 13 | Association of low serum concentra- tion of bi/irubin with increased risk of coronary artery disease 显示文摘 | Schwerther HA Jackson WG Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 14 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schewertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 15 | Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis显示文摘 | SKOBE M HAWIGHORST T JACKSON D G | 2001 | Nat Med2001，7，2： | 1 |
| 16 | A randomized placebo -control trial of fluvastatin for prevention of restenoeie after successful coronary ballon angioplasty:final resuils of the fluvastatin angiographic restenosis(FLARE) trial显示文摘 | Serruys PW Foley DP Jackson G Bonnier H Macaya C Vrolix M | 1999 | Eur Heart J1999，20，： | 1 |
| 17 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease 显示文摘 | Schwertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 18 | Paramagnetic resonance in carbonaceous solids显示文摘 | Ingram D J E Tapley J G Jackson R | 1954 | Nature1954，174，： | 1 |
| 19 | Control procedures for residuals associated with Principal Component Analysis显示文摘 | Jackson J E Mudholkar G S | 1979 | Technometrics1979，，： | 1 |
| 20 | Wall-to-platform migration in electrothermal atomic absorption spectrometry显示文摘 | Chen G Jackson K W | 2002 | Spectrochimica Acta Part B2002，53，： | 1 |
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