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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Rejection of Permacol~ mesh used in abdominal wall repair:A case report显示文摘Permacol mesh has shown promise when used in abdominal wall repair,especially in the presence of a contaminated surgical field.This biomaterial,derived from porcine dermis collagen,has proposed advantages over synthetic materials due to increased biocompatibility and reduced foreign body reaction within human tissues.However,we present a case report describing a patient who displayed rejection to a Permacol mesh when used in the repair of abdominal wound dehiscence following an emergency laparotomy.Review of the English language literature using PubMed and Medline, showed only two previously published cases of explantation of Permacoldue to sepsis or wound breakdown. The authors believe this is the first case of severe foreign body reaction leading to rejection of Permacol.Both animal and human studies show conflicting evidence of biocompatibility.There are several reports of successful use of Permacolto repair complex incisional herniae or abdominal walls in the presence of significant contamination.It appears from the literature that Permacolis a promising material,but as we have demonstrated,it has the potential to evoke a foreign body reaction and rejection in certain subjects. | Franchesca T Wotton Jacob A Akoh | 2009 | World Journal of Gastroenterology2009，15，34： | 2 |
| 3 | Synthesis and electrochemical performance of reduced graphene oxide/maghemite composite anode for lithium ion batteries显示文摘 | KIM I T MAGASINSKI A JACOB K | 2013 | Carbon2013，52，： | 1 |
| 4 | The effects of supply chain integration on customer satisfaction and financial performance : An organizational learning perspective 显示文摘 | YU W T JACOBS M A SALISBURY W D ENNS H | 2013 | International Journal of Production Economies2013，146，1： | 1 |
| 5 | Von Hippel-Lindau gene therapy : a novel strategy in limiting endo-thelial cell proliferative activity 显示文摘 | Jacob T Ascher E Hingorani A | 2001 | Ann Vase Surg2001，15，1： | 1 |
| 6 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Foam processing of poly ( ethylene - co - vinyl acetate ) rubber using supereritical carbon dioxide 显示文摘 | JACOBS M A KEMMERE M F KEURENTJES J T | 2004 | Polymer2004，45，： | 1 |
| 9 | Novel type of phase transitions in a system of self - driven particles 显示文摘 | VICSEK T CZIROK A JACOB E B | 1995 | Physical Review Letters1995，，75： | 1 |
| 10 | Phylogeneticsof Panicoideae (Poaceae) based on chloroplast and nuclear DNAsequences 显示文摘 | Teerawatananon A Jacobs S W L Hodkinson T R | 2011 | Telopea2011，13，11： | 1 |
| 11 | Thermal expansion anomalies and spontaneous magnetostriction in R2 Felt C intermetallic compounds 显示文摘 | Andreev A V De Boer F R Jacobs T H | 1991 | Physica B1991，175，： | 1 |
| 12 | Phosphati- dylinositol 3-kinase/AKT pathway activation in hu- man vestibular schwannoma 显示文摘 | JACOB A LEE T X NEFF B A | 2008 | Otol Neurotol2008，29，： | 1 |
| 13 | Probabilistic environmental risk of hazardous materials 显示文摘 | Jacobs T L Vesilind P A | 1992 | Journal of Environmental Engineering1992，118，6： | 1 |
| 14 | Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise 显示文摘 | Childs A Jacobs C Kaminski T | 2001 | Free Radic Biol Med2001，31，6： | 1 |
| 15 | Novel type of phase transitions in a system of self-driven particles显示文摘 | T Vicsek A Czirok E Ben Jacob | 1995 | Physical Review Letters (S0556-2813)1995，82，6： | 1 |
| 16 | Evidence for telo-merase activation in VSMCs exposed to hyperglycemic andhyperhomocysteinemic conditions显示文摘 | Jacob T Hingorani A Ascher EH | 2009 | Angiology2009，60，5： | 1 |
| 17 | The environmental impact of the use of avermeetin:environmental effects and fate显示文摘 | Halley B A Jacob T A Lu A Y H | 1989 | Chemospere1989，18，78： | 1 |
| 18 | Examination of the apoptotic pathway and proteolysis in the pathogenesis of popliteal artery aneurysms显示文摘 | Jacob T Hingorani A Ascher E | 2001 | Eur J Vasc Endovasc Surg2001，22，： | 1 |
| 19 | Heat shock-mediated suppression of ODC protein expression in colorectal cancer cells显示文摘 | Wales C T K Jacobs A T | 2014 | Cancer Res2014，74，19： | 1 |
| 20 | Composition and morphology of wear debris in failed uncementen total hip replacement 显示文摘 | A S Shanbhag J J Jacobs T T Giant | 1994 | J Bone Joint Surg Br1994，76，1： | 1 |
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