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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 3 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 4 | Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease 显示文摘 | Das M K Khan B Jacob S | 2006 | Circulation2006，113，2： | 1 |
| 5 | A genomewide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer显示文摘 | HUNTER D J KRAFT P JACOBS K B | 2007 | Nature genetics2007，39，7： | 1 |
| 6 | Homocysteine as arisk factor for ischem icstroke: an epidem iological story in evolution 显示文摘 | SACCO R L ROBERTS J K JACOBS B S | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 7 | The role of the complement cascade in endotoxin-induced septic encephalopathy显示文摘 | Jacob A Hensley L K Safratowich B D | 2007 | Laboratory Investigation2007，87，： | 1 |
| 8 | Liquid chromatography-mass spectrometry identification of imidacloprid photolysis products 显示文摘 | Ding T Jacobs D Lavine B K | 2011 | Microchemical Journal2011，99，2： | 1 |
| 9 | Mineral composition of pigeon milk显示文摘 | B Shenoy K Jacob R T | 1990 | Experientia1990，46，： | 1 |
| 10 | Weight gain in type 2 diabetes mellitus显示文摘 | Jacob AN Salinas K Adams-Huet B | 2007 | Diabetes Obes Metab2007，9，： | 1 |
| 11 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 12 | Homocysteine as risk factor for ischemic stroke:an epidemiological story in evolution显示文摘 | Sacco R L Roberts J K Jacobs B S | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 13 | Vaccinia virus vaccines:past,present and future显示文摘 | Jacobs B L Langland J O Kibler K V | 2009 | Antiviral Res2009，84，1： | 1 |
| 14 | Moderate controlled hypotension with sodium nitroprusside does not improve surgical condition or decrease blood loss in endoscopic sinus surgery 显示文摘 | JACOBIC K E BOHM B E RICKAUER A J | 2000 | J Clin Anesth2000，12，： | 1 |
| 15 | Homocysteine as a risk factor for ischemic stroke:an epidemiological story in evolution显示文摘 | Sacco R L Roberts J K Jacobs B S | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 16 | Reference gene selection for insect ex- pression studies using quantitative real-time PCR:The head of the honeybee, Apis mellifera, after a bacterial challenge显示文摘 | SCHARLAKEN B GRAAF D C GOOSSENS K BRUNAIN M PEELMAN L J JACOBS F J | 2008 | Insect Sci- ence2008，8，： | 1 |
| 17 | EGFR in melanoma:clinical significance and potential therapeutic target显示文摘 | Boone B Jacobs K Ferdinande L | 2011 | J Cutan Pathol2011，38，6： | 1 |
| 18 | Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease显示文摘 | Das M K Khan B Jacob S | | 0，，： | 1 |
| 19 | Quantifying hydrodynamic slip a comprehensive analysis of dewetting profiles 显示文摘 | Fetzer R Munch A Wagner B Rauscher M Jacobs K | 2007 | Langmuir2007，23，10： | 1 |
| 20 | Release of an inva- sion promoter E-cadherin fragment by matrilysin and str- pmelysin- 1显示文摘 | Noe V Fingleton B Jacobs K | 2001 | J Cell Sci2001，114，： | 1 |
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