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| 1 | Molecular mechanisms of insulin resistance in chronic hepatitis C显示文摘It is now widely recognized that chronic hepatitis C (CHC)is associated with insulin resistance(IR)and type 2 diabetes,so can be considered a metabolic disease.IR is most strongly associated with hepatitis C virus(HCV)genotype 1,in contrast to hepatic steatosis, which is associated with genotype 3 infection.Apart from the well-described complications of diabetes,IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular carcinoma.More recently,it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well defined.This review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR. | Mark W Douglas Jacob George | 2009 | World Journal of Gastroenterology2009，15，35： | 16 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 4 | Void fill and support techniques to stabilize drift excavated through a transition zone mined by a TBM at the Stillwater mine显示文摘Stillwater Mining Company is the only U.S. producer of platinum group metals(PGMs) and the largest producer outside of South Africa and Russia. The company controls a considerable portion of the J-M reef and is currently developing the ‘‘Blitz Project,' which will provide a main haulage level, ore pass systems,backfill plants, and flow-through ventilation to increase production and ensure sustainable extraction of this critical strategic mineral. While driving two sub-parallel footwall laterals 8125 m in length, one of the development drifts experienced a massive fall in a geologically disturbed area created by a mafic dike intrusion. Combinations of a void fill material(Tekseal), polyurethane injection, fore poling coupled with steel arches, and supplemental bolting allow safe and efficient advance through this geologically disturbed zone. This paper presents the details of this project. | Johnson Josh Jacobs Curt Ferster Mark Tadolini Stephen | 2017 | International Journal of Mining Science and Technology2017，27，1： | 2 |
| 5 | Retinoid content,visual responses,and ocular morphology are compromised in the retinas of mice lacking the retinolcbinding protein receptor,STRA6显示文摘 | Ruiz A Mark M Jacobs H | 2012 | Invest Ophthalmol Vis Sci2012，53，： | 1 |
| 6 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 7 | The history of awake craniotomy for brain tumor and its spread into Asia显示文摘 | Julius July Pirjo Manninen Jacob Lai Zhenhai Yao Mark Bernstein | 2009 | Surgical Neu- rology2009，71，5： | 1 |
| 8 | Review of adolescent urinary tract infection显示文摘 | Mark Horowitz Jacob Cohen | 2007 | Current Urology Reports2007，，4： | 1 |
| 9 | A combination solution for routine pupillary dilation显示文摘 | David M. Krumholz Joan K. Portello Mark Rosenfield Jacob D. Rosenbaum | 2006 | Optometry - Journal of the American Optometric Association2006，，7： | 1 |
| 10 | Isolation of antileishmanial,antimalarial and antimicrobial metabolites from Jatropha multifida显示文摘Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections. | Abiodun Falodun Vincent Imieje Osayewenre Erharuyi Ahomafor Joy Peter Langer Melissa Jacob shabanna Khan Mohammed Abaldry Mark Hamann | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，5： | 1 |
| 11 | Roux-en-Y jejunostomy button in infants显示文摘 | Jacob C Langer Mark V | 2000 | Pediatr Surg Int2000，16，1： | 1 |
| 12 | Tensile strength of 〈1<ce:hsp sp='0.12'/>0<ce:hsp sp='0.12'/>0〉 and 〈1<ce:hsp sp='0.12'/>1<ce:hsp sp='0.12'/>0〉 tilt bicrystal copper interfaces显示文摘 | Douglas E. Spearot Mark A. Tschopp Karl I. Jacob David L. McDowell | 2006 | Acta Materialia2006，，2： | 1 |
| 13 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 14 | Cognitive-Behavioral Therapy for Adolescent Depression: A Meta-Analytic Investigation of Changes in Effect-Size Estimates显示文摘 | JESSE B. KLEIN RACHEL H. JACOBS MARK A. REINECKE | 2007 | Journal of the American Academy of Child & Adolescent Psychiatry2007，，11： | 1 |
| 15 | Serous microcystic adenoma ( glyco- gen rich cystadenoma) of the pancreas显示文摘 | Jacob S Rawat P Mark R P | 2010 | Indian J Pathol Micro- biol2010，53，1： | 1 |
| 16 | Transanal one-stage Soave procedure for infants with Hirschsprung's disease显示文摘 | Robert K Mark V | 1999 | J Pediatric Surgery1999，34，： | 1 |
| 17 | Hiatal hernia repair with mesh: a survey of SAGES members显示文摘 | Constantine T. Frantzides Mark A. Carlson Sofronis Loizides Anastasia Papafili Mihn Luu Jacob Roberts Tallal Zeni Alexander Frantzides | 2010 | Surgical Endoscopy2010，，5： | 1 |
| 18 | Stra8-deficient spermatocytes initiate,but fail to complete,meiosis and undergo premature chromosome condensation显示文摘 | Mark M Jacobs H Oulad-Abdelghani M | 2008 | J Cell Sci2008，121，19： | 1 |
| 19 | STRA8-deficientspermatocytes initiate,but fail to complete,meiosis and undergo prematurechromosome condensation显示文摘 | MARK M JACOBS H OULAD-ABDELGHANI M | 2008 | J Cell Sci2008，121，： | 1 |
| 20 | Acute nonlymphocytic leukemia following toposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung显示文摘 | Mark J Lynne S Jacob D | 1987 | Blood1987，70，5： | 1 |
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