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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production显示文摘 | Edgerton D S Jacobson P B Opgenorth T Jet cd | 2006 | Metabolism2006，55，9： | 1 |
| 3 | Endoradiosonde 显示文摘 | Mackay R S Jacobson B | 1957 | Nature1957，179，： | 1 |
| 4 | Diagnosis of thrombosis by catheter phlebography after prolonged central venous catheterization显示文摘 | Brismar B Hardstedt C Jacobson S | 1981 | Ann Surg1981，194，： | 1 |
| 5 | Sample filtration,concentration,and separation integrated on microfluidicdevices显示文摘 | Broyles B S Jacobson S C Ramsey J M | 2003 | Anal Chem2003，75，： | 1 |
| 6 | Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical Cancer显示文摘 | Jacobson G M Kamath R S Smith B J | 2005 | Gynecol Oncol2005，96，： | 1 |
| 7 | Water maze per- formance in young male Long - Evans rats is inversely affected by dietary intakes of niacin and may be linked to levels of the NAD metabolite cADPR显示文摘 | Young G S Jacobson E L Kirkland J B | 2007 | J Nutr2007，137，4： | 1 |
| 8 | A new spin on an old model:in vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Morgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 9 | High - speed separations on a microchip 显示文摘 | Jacobson S C Hergenroder R Koutny L B | 1994 | Anal Chem1994，66，： | 1 |
| 10 | A new spin on an old model: In vivo evaluation of disease progression magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Borgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，： | 1 |
| 11 | Application of discrete event simulation in health care clinics:a survey显示文摘 | Jun J B Jacobson S H Swisher J R | 1999 | Journal of Operational Research Society1999，50，： | 1 |
| 12 | Evidence - based feeding guidelines for very low - birth - weight infants 显示文摘 | PREMJI S S PAES B JACOBSON K | 2002 | Adv Neonatal Care2002，2，1： | 1 |
| 13 | Carbonic anhydrase of spinach显示文摘 | Fong F Heath R L | 1975 | Plant Physiol1975，55，： | 1 |
| 14 | Pharmacological characterization of thepseudopterosins: novel anti-inflammatory natural products isolated form the Caribbean soft coral, Pseudopterogorgia elisabethae 显示文摘 | Mayer M S A Jacobson P B Fenical W | 1998 | Pharm Lett1998，62，26： | 1 |
| 15 | Acetazolamide inhibition of photosystem in isolated spinach chloroplasts显示文摘 | Jacobson B S | 1972 | Phytochemistry1972，，11： | 1 |
| 16 | Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices显示文摘 | JACOBSON S C HERGENRODER R KOUTNY L B | 1994 | Anal Chem1994，66，7： | 1 |
| 17 | Correlation between soluble markers of endothelial dysfunction in patients with renal failure显示文摘 | JACOBSON S H EGBERG N HYLANDER B | 2002 | Am J Nephrol2002，22，1： | 1 |
| 18 | Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices 显示文摘 | JACOBSON S C HERGENRODER R KOUTNYL B | 1994 | Anal Chem1994，66，7： | 1 |
| 19 | A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Borgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 20 | Microehip capillary electrophoresis with an integrated postcolumn reactor 显示文摘 | JACOBSON S C KOUTNY L B HERGENR-ODER R | 1994 | Analthem1994，66，20： | 1 |
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