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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | First isolation of glutinol and a bioactive fraction with good antiinflammatory activity from n-hexane fraction of Peltophorum africanum leaf显示文摘Objective: To investigate the anti-inflammatory activity of different fractions and glutinol(isolated compound),using nitric oxide synthase and cyclooxygenase(COX) inhibition as an indication of anti-inflammatory activity,Methods: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model,Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions,Results: Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited(P = 0.01) the catalytic activity of COX-2(IC50 = 0.67 μg/m L) better than isolated compound,glutinol(IC50 = 1.22 μg/m L),compound 2(CP2)(IC50 = 1.71 μg/m L) and sub-fraction F3.3.0(IC50 = 1.30 μg/m L),A similar trend was observed in investigation of the inhibition of nitric oxide synthesis in RAW 264.7 cells by F3.3,glutinol,CP2 and F3.3.0,Inducible COX-2 and inducible nitric oxide synthase are among potent signalling enzymes that exacerbate inflammation,Conclusions: Bioactive sub-fractions(F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity,and the isolated compound,and glutinol may be useful as a template for the development of new anti-inflammatory drugs. | Salmon A Adebayo Leshweni J Shai Jacobus N Eloff | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 2 |
| 3 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 4 | Burnout,engagement,coping and general health of service employees in the hospitality industry显示文摘 | JACOBUS PIENAAR SHARRON A WILLEMSE | 2008 | Tourism Management2008，29，6： | 1 |
| 5 | In vitro activities of tigecycline against the Bacteroides fragilis group 显示文摘 | Jacobus N V MclDermott L A Ruthazer R | 2004 | Antimicrob Agents Chemother2004，48，3： | 1 |
| 6 | Sliding Transformers for Linear Contactless Power Delivery显示文摘 | Jacobus M Barnard Jan A Ferreira Jacobus Daniel van WyK | 1997 | IEEE Transactions on Industrial Electronics1997，44，： | 1 |
| 7 | The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+T lymphocytes显示文摘 | James A Thompson Minu K Srivastava Jacobus J | 2008 | Cancer immunology immunotherapy:CII2008，57，3： | 1 |
| 8 | Continuous synthesis of NaA zeolite membranes 显示文摘 | Sonia A Jorge G Jacobus C J | 2009 | Microporous and Mesoporous Materials2009，120，： | 1 |
| 9 | Optimal aluminum-assisted mesoporosity development in MFI zeolites by desilieation 显示文摘 | Johan C Groen Jacobus C Jansen Jacob A Moulijn | 2004 | J Phys Chem B2004，108，13： | 1 |
| 10 | Primary therapy with single agent bortezomib as induction,maintenance and re-induction in patients with high-risk myeloma:results of the ECOG E2A02 trial显示文摘 | Dispenzieri A Jacobus S Vesole DH | 2010 | Leukemia2010，24，8： | 1 |
| 11 | Assessment of the healing process in distal radius fractures by high resolu- tion peripheral quantitative computed tomography显示文摘 | Joost J A de Jong Paul C Willems Jacobus J Arts | 2014 | Bone2014，64，7： | 1 |
| 12 | Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomized controlled trial显示文摘 | Philip A Poole-Wilson Jacobus Lubsen Bridget-Anne Kirwan | 2004 | Lancet2004，364，： | 1 |
| 13 | Primary therapy with single agent bortezomib as induction,mainte-nance and re-induction in patients with high-risk myeloma:results of the ECOG E2A02 trial显示文摘 | Dispenzieri A Jacobus S Vesole DH | | 0，，： | 1 |
| 14 | MAP kinase pathways in the yeast Saccharomyces cerevisiae 显示文摘 | Gustin M C Jacobus A Alexander M | 1998 | Microbiology and Molecular Biology Reviews1998，62，4： | 1 |
| 15 | 显示文摘 | ALEXANDER A R RALUCA I S JACOBUS F V S | 2004 | Talanta2004，64，： | 1 |
| 16 | Comparative in vitro and in vivo activities of piperacillin combined with the β-lactamase inhibitors tazobactam,clavulanic acid,and sulbactam显示文摘 | Jacobus N V Petersen P J | 1989 | Antimicrob Agents Chemother1989，33，4： | 1 |
| 17 | Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls:A theoretical structure–activity assessment显示文摘 | Luthe G Jacobus J A Robertson L W | 2008 | Environmental Toxicology and Pharmacology2008，25，2： | 1 |
| 18 | National survey on the susceptibility of bacteroides fragilis group:report nd analysis of trends in the united states from, 1997 to 2004 显示文摘 | Snydman DR Jacobus NV Mcdermott A Et al | 2007 | Antimicrob Agents Chemother2007，51，5： | 1 |
| 19 | Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone:calcium inflow and electrophysiological changes显示文摘 | Loss E S Jacobus A P Wassermann G F | 2011 | Life Sci2011，89，1516： | 1 |
| 20 | Comparative in vitro and invive activities of pipercilin combined with the β lactamase inhibitors tazobactam,clavulanic acid,and sulbactam显示文摘 | Kuck N A Jacobus N C Petersen P J | 1989 | Antimicrob Agents Chemother1989，33，： | 1 |
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