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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre:A prospective cost analysis during the learning curve显示文摘AIM To evaluate the costs of the introduction of a laparoscopic surgery program for gastric cancer in a Western community training hospital and tertiary referral centre for gastric cancer surgery. METHODS All patients who underwent surgery for gastric cancer with curative intent in 2013 and 2014 were prospectively included. Primary outcomes were costs regarding surgery and hospital stay. RESULTS Laparoscopic gastrectomy was used in 52 patients [mean age 68 years(± 9, range 50 to 87) years] and open gastrectomy was used in 25 patients [mean age 70 years(± 10, range 46 to 85)]. Mean costs(in euro's) of surgical instrumentation were significantly higher for laparo-scopic surgery: 2270 ± 670 vs 1181 ± 680 in the open approach(P < 0.001). Costs of theatre use were higher in the laparoscopic group: mean 3818 ± 865 vs 2545± 1268 in the open surgery(P < 0.001). Total costs of hospitalization(i.e., costs of surgery and admission)were not different between laparoscopic and open surgery, 8187 ± 4864 and 6152 ± 2680 respectively(P= 0.729). Mean length of hospital stay was 9 ± 12 d in the laparoscopic group vs 14 ± 14 d in the open group(P= 0.044). CONCLUSION The introduction of laparoscopic gastrectomy for gastric cancer coincided with higher costs for theatre use and surgical instrumentation compared to the open technique. Total costs were not significantly different due to shorter length of stay and less intensive care unit(ICU) admissions and shorter ICU stay in the laparoscopic group. | Juul J Tegels Charlotte E Silvius Frederique E Spauwen Karel W Hulsewé Anton G Hoofwijk Jan H Stoot | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 2 |
| 3 | Applications for activated carbons from used tires : Butane working capacity 显示文摘 | JAN L A JENNIFER L G PETER C E | 1999 | Carbon1999，37，9： | 1 |
| 4 | Full-scale measurements of so2 gas phase concentrtions and slurry compositions in a wet flue gas desulphurisation spray absorber显示文摘 | HELLE G NYGAARD SOREN KILL JAN E JOHNSSON | 2004 | Fule2004，，83： | 1 |
| 5 | Design and evaluation of the LOPES exoskeleton robot for interactive gait rehabilitation 显示文摘 | Jan F V Rik K Hekman E E G | 2007 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2007，15，3： | 1 |
| 6 | Raman spectroscopy as tool for the characterization of thio-polyaromatic hydrocarbons in organic minerals显示文摘 | Otakar F Jan J Howell G M E | 2007 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2007，68，4： | 1 |
| 7 | Inhibition of gibberellin biosynthesis by paclobutrazol in cell-free homogenates of Cucurbita maxima Endosperm and Malus pumila Embryos显示文摘 | Peter H Jan E G | 1985 | J Plant Growth Regul1985，，4： | 1 |
| 8 | On the Existence of an Optimal Capital Structure: Theory and Evidence显示文摘 | Bradley M Jan'ell G A Kim E H | 1984 | The Journal of Finance1984，39，3： | 1 |
| 9 | A New Measure Health Status for Clinical Trials in Inflammatory Bowel Disease显示文摘 | Gordon G Alba M E Jan I | 1989 | Gastroenterology1989，96，： | 1 |
| 10 | Effects of agronom- ical measures on the microbial diversity of soils as re-lated to the suppression of soil-borne plant pathogens 显示文摘 | Jan Dirk V E Paolina G Joana S | 2002 | Biodegradation2002，13，1： | 1 |
| 11 | Process for Production of High Density/High Performance Binderless Boards from Whole Coconut Husk 显示文摘 | DAM Jan E G Van OEVER Martien J A Van Den TE- UNISSEN Wouter | 2006 | Industrial Crops and Products2006，24，2： | 1 |
| 12 | A method for searching optimal routes with collision avoidance on raster charts 显示文摘 | CHANG K Y JAN G E PARBERRY I | 2003 | The journal of navigation2003，56，3： | 1 |
| 13 | On dicyclopentadiene isomers显示文摘 | Malgorzata E J Slawomir G Jan C D | 2003 | Journal of Molecular Structure (Theochen)2003，634，： | 1 |
| 14 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 15 | SSEP-domain : Protein Domain Prediction by Alignment of Secondary Structure Elements and Profiles 显示文摘 | Jan E G Ralf Z | 2006 | Bioinformatics2006，22，2： | 1 |
| 16 | Applications for activated car bons from used tires:butane working capacity显示文摘 | Jan L A Jennifer L G Peter C E | 1999 | Carbon1999，37，： | 1 |
| 17 | AP1 factor inactiva- tion in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen- dependent tumor formation显示文摘 | Rorke E A Adhikary G Jans R | 2010 | Oncogene2010，29，44： | 1 |
| 18 | Phase U study of sunitinib administered in a continuous once-daily dosing regimen in pa- tients with cytokine-refractory metastatic renal cell carcinoma 显示文摘 | Bernard E Jan R Silke G | 2009 | J Clin Oncol2009，27，25： | 1 |
| 19 | Microbes from Raw Milk for Fermented Dairy Products显示文摘 | JAN T M W EMAN H E A HUGENHOLTZ J SMIT G | 2002 | Int Dairy J2002，12，： | 1 |
| 20 | Full - scale measure- ments of SO2 gas phase concentrations and slurry compositions in a wet flue gas desulphurisation spray absorber显示文摘 | Nygaarda H G SOren kiilb Johnsson Jan E | 2004 | Fuel2004，，83： | 1 |
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