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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | C-Methyl-flavonoids from the leaf waxes of some Myrtaceae显示文摘 | Eckhard Wollenweber Rüdiger Wehde Marion D?rr Günter Lang Jan F Stevens | 2000 | Phytochemistry2000，，8： | 1 |
| 3 | Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study显示文摘 | Bernard G F Jacques A van V Jan G K | 2004 | Chest2004，125，： | 1 |
| 4 | PRISMA-DB A parallel main memory relational DBMS 显示文摘 | PETER M G A CAREL A V D B JAN F | 1992 | IEEE Transactions on Knowledge and Data Engineering1992，4，6： | 1 |
| 5 | Application of ionic liquids in analytical chemistry 显示文摘 | LIU J F JAN A J JIANG G B | 2005 | Trends Anal Chem2005，24，1： | 1 |
| 6 | Design and evaluation of the LOPES exoskeleton robot for interactive gait rehabilitation 显示文摘 | Jan F V Rik K Hekman E E G | 2007 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2007，15，3： | 1 |
| 7 | Raman spectroscopy as tool for the characterization of thio-polyaromatic hydrocarbons in organic minerals显示文摘 | Otakar F Jan J Howell G M E | 2007 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2007，68，4： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Tightly coupled GPS/INS integration for missile applications 显示文摘 | Jan W Trommer G F | 2004 | Aerospace Science and Technology2004，8，7： | 1 |
| 10 | Calibration of fundus images using spectral domain optical coherence tomography显示文摘 | Lu jan BJ Wang F Gregori G | 2008 | Ophthalmic Surg Lasers lmaging2008，3，： | 1 |
| 11 | Effect of sorption kinetics on nickel toxicity in methanogenic granular sludge 显示文摘 | JAN B FERNANDO G F Alba B C | 2010 | Journal of Hazardous Materials2010，180，： | 1 |
| 12 | Discriminating between critical and nncritical disturbances in (Bio) chemical bach processes prediction Research, NAES T, using m 显示文摘 | GEERT G JEF V JAN F | 2012 | ulti-model fault detection and end-quality Industrial and Engineering Chemistry2012，51，1： | 1 |
| 13 | Binding of the G domains of lamininα1 and α2 chains and perlecan to heparin sulfatides, α-dystroglycan and several extracellular matrix proteins显示文摘 | Zeynep Andac Walter Gohring | 1999 | EMBO J1999，18，： | 1 |
| 14 | Contraleptive potetiat of Ru486 by Ovalation inhibition显示文摘 | Jan FHM VanVen Jeng G Glaudio F | 1989 | Contraception1989，40，3： | 1 |
| 15 | Evaluation of follicular oxidant - antioxidant balance and oxidative damage during reproductive aeyclicity in water Buffalo 显示文摘 | JAN M H DAS G K KHAN F A | 2014 | Asian Pacific Journal of Reproduction2014，3，1： | 1 |
| 16 | Evolution of the family of intracellular lipid binding proteins in vertebrates显示文摘 | Frank G Schaap Ger J vander Vusse Jan F C Glatz | 2002 | Mol Cell Biochem2002，239，： | 1 |
| 17 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 18 | Discriminating between critical and noncritical disturbances in (Bio) chemical bach processes using multi-model fault detection and end-quality prediction 显示文摘 | GEERT G JEF V JAN F | 2012 | Industrial and Engineering Chemistry Research2012，51，12： | 1 |
| 19 | Percutaneous transradial artery approach for coronary stent implantation 显示文摘 | Kiemeneij F Jan Laarman G | 1993 | Cathet Cardiovasc Diagn1993，30，2： | 1 |
| 20 | Discriminating between critical and noncritical disturbances in chemical batch process using multimode fault detection and end-quality prediction 显示文摘 | GEER G JEF V JAN F M | 2012 | Industrial and Engineering Chemistry Research2012，51，12： | 1 |
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