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| 1 | 加强流行病学中观察性研究报告质量(STROBE)声明:观察性研究报告规范显示文摘很多生物医学研究都是观察性的。但对这类研究的报告却通常不完整,从而限制了对其优缺点及普适性的评价。“加强流行病学中观察性研究报告质量(STROBE)”工作组针对一篇完整明确的观察性研究报告应包括的内容提供了一套建议。建议涵盖了流行病学研究的三种主要设计类型:队列设计、病例对照设计和横断面设计。2004年9月,我们召开了为期2天的研讨会,与会的方法学专家、研究人员和期刊编辑共同起草了一份观察性研究报告应纳入的条目清单草案。此后,又通过协调小组数次会议及与有关人员电子邮件讨论等对该草案进行了修改,纳入了经验性证据和方法学方面的意见。通过研讨会及之后反复的咨询和修订,我们制定出了一个包含22个条目的清单(STROBE声明),分为论文的题目、摘要、引言、方法、结果和讨论等部分。其中18个条目适用于所有三种主要的观察性研究设计,其余4个条目则专门用于队列、病例一对照或横断面设计。详细的解释和示范文件已另行发表,在《公共科学图书馆一医学》(PLoS Medicine)、《内科学年报》(Annalsof Internal Medicine)和《流行病学》(Epidemiology)的网站可以免费获得。我们希望STROBE声明能有助于改善观察性研究报告的质量。 | Erikvon Elm Douglas G Altman Matthias Egger Stuart J Pocock Peter C G tzsche Jan P Vandenbroucke 赵乐(译) 邹光勇(审) 杜怀东(审) | 2008 | 世界临床医学2008，2，1： | 12 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Pulmonary hypertension in hereditary haemorrhagic telangiectasia显示文摘Hereditary haemorrhagic telangiectasia(HHT) is an autosomal dominant inherited disorder characterised by vascular malformations in predominantly the brain,liverand lungs.Pulmonary hypertension(PH) is increasingly recognised as a severe complication of HHT.PH may be categorised into two distinct types in patients with HHT.Post-capillary PH most often results from a high pulmonary blood flow that accompanies the high cardiac output state associated with liver arteriovenous malformations.Less frequently,the HHT-related gene mutations in ENG or ACVRL1 appear to predispose patients with HHT to develop pre-capillary pulmonary arterial hypertension.Differentiation between both forms of PH by right heart catheterisation is essential,since both entities are associated with severe morbidity and mortality with different treatment options.Therefore all HHT patients should be referred to an HHT centre. | Veronique MM Vorselaars Sebastiaan Velthuis Repke J Snijder Jan Albert Vos Johannes J Mager Martijn C Post | 2015 | World Journal of Cardiology2015，7，5： | 4 |
| 4 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 5 | Tracing photoinduced electron transfer process in conjugated polymer/fullerene bulk heterojunctions in real time显示文摘 | Christoph J Brabec Gerald Zerza Giulio Cerullo Sandro De Silvestri Silvia Luzzati Jan C Hummelen Serdar Sariciftci | 2001 | Chemical Physics Letters2001，，3： | 1 |
| 6 | Total ankle prostheses in rheumatoid arthropathy显示文摘 | Huub JL van der Heide Bernard Schutte Jan Willem K Louwerens Frank H J van den Hoogen Maarten C de Waal Malefijt | 2009 | Acta Orthopaedica2009，，4： | 1 |
| 7 | Hepatitis B virus surface antigen can activate human monocyte-derived dendritic cells by nuclear factor kappa B and p38 mitogen-activated protein kinase medi- ated signaling显示文摘 | Jan R H Lin Y L Chen C J | 2012 | Microbiol Immunol2012，5610，： | 1 |
| 8 | Development trends for insertion devices of future synchrotron light sources显示文摘 | Hwang C S Jan J C Chang C S | 2011 | Physical Review Special Topics- Accelera- tors and Beams2011，14，04： | 1 |
| 9 | Parecoxib sodium administered over several days reduces pain after gynecologic surgery via laparotomy显示文摘 | Michael C Artur J Jan Kotarski | 2007 | J Clin Anesth2007，19，6： | 1 |
| 10 | A mobile ticket system based on personal trusted device显示文摘 | CHEN Y Y CHEN C L JAN J K | 2007 | Wireless Personal Communications2007，40，4： | 1 |
| 11 | The anomalous amplification of M2 tide in the Taiwan Strait显示文摘 | Jan S Chern C S Wang J | 2004 | Geophysical Research Letters2004，31，： | 1 |
| 12 | PhaseⅢ study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival 显示文摘 | Lin J C Jan J S Hsu C Y | 2003 | J Clin Oncol2003，21，4： | 1 |
| 13 | Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute re- spiratory syndrome coronavirus 显示文摘 | Wen C C Kuo Y H Jan J T | 2007 | J Med Chem2007，50，17： | 1 |
| 14 | The response of and sound power radiation by a clamped rectangular plate显示文摘 | SUNG C C JAN J T | 1997 | Journal of Sound and Vibration1997，207，3： | 1 |
| 15 | Farm-level effects of adopting herbicide-tolerant soybeans in the USA显示文摘 | Femandez-Comejo J Klotz-Ingram C Jans S | 2002 | Journal of Agricultural and Applied Economics2002，34，： | 1 |
| 16 | Working memory in children with autism and with moderate learning difficulties 显示文摘 | Russell J Jan'old C Henry L | 1996 | J Psychol Psy- chiatr1996，37，6： | 1 |
| 17 | Turnip mosaic potyvirus resistance in Nicotiana benthamiana derived by post-transcriptional gene silencing显示文摘 | Jan F J Pang S Z Fagoaga C | 1999 | Transgenic Research1999，8，： | 1 |
| 18 | Complete nucleotide sequence and genetic organization of papaya ringspot virus RNA显示文摘 | Yeh S D Jan F J Chiang C H | 1992 | J Gen Virol1992，73，10： | 1 |
| 19 | Application of artificial neural networks in typhoon surge forecasting显示文摘 | Tseng C M Jan C D Wang J S | 2007 | Ocean Engineering2007，34，1112： | 1 |
| 20 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies显示文摘 | Erik von Elm Douglas G Altman Matthias Egger Stuart J Pocock Peter C G?tzsche Jan P Vandenbroucke | 2007 | The Lancet2007，，9596： | 1 |
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