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6篇 您的检索式:作者名="Janet Rossant"
    题名 作者 年代 出处 被引量
1Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo显示文摘Amy Ralston Janet Rossant 2007Developmental Biology2007,,2:1
2Direct Neural Fate Specification from Embryonic Stem Cells显示文摘Vincent Tropepe Seiji Hitoshi Christian Sirard Tak W Mak Janet Rossant Derek van der Kooy 2001Neuron2001,,1:1
3Cell fate decisions in early blood vessel formation显示文摘M asatsugu E ma and Janet Rossant 2003Trends Cardiovasc Med2003,13,:1
4Studying human embryo development with E-assembloids显示文摘Stem cell-based models of early human embryo development can provide important insights into key stages of human pregnancy.In a recent Cell Research study,based on data obtained from their detailed analysis of gene expression in intact human embryo cultures,Ai and colleagues document the formation of stem cell‘E-assembloids’that mimic morphogenetic events of early human post-implantation development in vitro.Janet Rossant 2023Cell Research2023,33,10:0
5Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling显示文摘The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development.Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation.Here,we demonstrate that through brief inhibition of Nodal signaling in vitro,mouse embryonic stem cell(ESC)-derived epiblast stem cells(ESD-EpiSCs)could be committed to transient ectodermal progenitor populations,which possess the ability to give rise to neural or epidermal ectoderm in the absence or presence of BMP4,respectively.Mechanistic studies reveal that BMP4 recruits distinct transcriptional targets in ESD-EpiSCs and ectoderm-like cells.Furthermore,FGF–Erk signaling may also be alleviated during the generation of ectoderm-like cells.Thus,our data suggest that instructive interactions among several extracellular signals participate in the commitment of ectoderm from ESD-EpiSCs,which shed new light on the understanding of the formation of ectoderm during the gastrulation in early mouse embryo development.Lingyu Li Lu Song Chang Liu Jun Chen Guangdun Peng Ran Wang Pingyu Liu Ke Tang Janet Rossant Naihe Jing 2015Journal of Molecular Cell Biology2015,7,5:0
6Depending on maternal Yap显示文摘Eszter Posfai Janet Rossant 2016Cell Research2016,26,4:0
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