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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 3 | Emissions of organophosphate and brominated flame retardants from selected consumer products and building materials显示文摘 | Kemmlein S Hahn O Jann O | 2003 | Atmos Environ2003，37，3940： | 1 |
| 4 | The survival of patients treated for limited stage small cell lung cancer in North America has increased during the past 20 years显示文摘 | Janne PA Freidlin B Saxman S | 2001 | Proc Am Cancer Soc2001，20，： | 1 |
| 5 | Twenty-five years of clinical research for patients with limited-stage small cell lung carcinoma in North America显示文摘 | Janne PA Freidlin B Saxman S | 2002 | Cancer2002，95，7： | 1 |
| 6 | Self-reported empathic a- bilities in schizophrenia: A longitudinal perspective 显示文摘 | Haker H Schimansky J Jann S | 2012 | Psychia- try Res2012，200，23： | 1 |
| 7 | EGFR mutations in hmg cancer: Correlation with clinical response to gefitinib therapy 显示文摘 | Paez JG Janne PA Lee JC Traey S Greulich H Gabriel S el al | 2004 | Science2004，304，4： | 1 |
| 8 | Structure of the 016 polysaccharide from escerichia coli 016: KI: an NMR investigation 显示文摘 | Jann B Alexander S Shashkov | 1994 | Carbohydrate Research1994，264，： | 1 |
| 9 | Twenty-five years of clinical research for patients with limited-stage small cell lung carcinoma in North America显示文摘 | Janne PA Freidlin B Saxman S | 2002 | Cancer2002，95，7： | 1 |
| 10 | Diagnosis, treatment and follow - up of the carpal syndrome : a review 显示文摘 | Alfonso C Jann S Massa R | 2010 | Neurol Sei2010，31，3： | 1 |
| 11 | Outcomes of patients with advanced non-small-cell lung cancer treated with gefitinib (ZD1839, 'lressa')on an expanded access study显示文摘 | JANNE PA GURUBHAGAVATULA S YEAP BY | 2004 | Lung Cancer2004，44，2： | 1 |
| 12 | Optimization of electricity retailer's contract portfolio subject to risk preferences显示文摘 | Janne K Ahti S Derek W B | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 13 | Multi-center assessment of the Total Neuropathy Score for chemotherapy-induced peripheral neurotoxicity显示文摘 | Cavaletti G Jann S Pace A | 2006 | J Peripher Nerv Syst2006，11，2： | 1 |
| 14 | Retrievable versus permanent caval filter procedures:when are they cost-effective for interventional radiology?显示文摘 | Janne d′Othée B Faintuch S Reedy AW | 2008 | J Vasc Interv Radiol2008，19，3： | 1 |
| 15 | Stabilization of mercury containing sludge by a combined process of 2-stage pretreatment and solidification 显示文摘 | Chang C Y Hsu C P Jann J S | 1993 | Journal of Hazardous Material1993，35，1： | 1 |
| 16 | Diagnosis,treatment and follow up of the carpal tunnel syndrome:a review显示文摘 | Alfonso C Jann S Massa R | 2010 | Nurol Sci2010，31，3： | 1 |
| 17 | Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib(ZD1839,'Iressa')on an expanded access study显示文摘 | Janne PA Gurubhagavatuls S Yeap BY | 2004 | Lung Cancer2004，44，2： | 1 |
| 18 | Expanding the ecological niche approach: Relationships between variability in niche position and species richness显示文摘 | Janne S Jani H Jyrki L Risto V | 2011 | Ecological Complexity2011，8，1： | 1 |
| 19 | Diagnostic value of su- ral nerve matrix metalloproteinase-9 in diabetic patients with CIDP显示文摘 | Jann S Bramerio MA Beretta S | 2003 | Neurology2003，61，11： | 1 |
| 20 | Molecular clo?ning and characterization of Toll-like receptors 1-10 in sheep显示文摘 | CHANGJ S RUSSELL G C JANN 0 | 2009 | Vet Immunol Irnmunopathol2009，127，12： | 1 |
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