|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Outcome of untreated traumatic articular cartilage defects of the knee:a natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，852，： | 1 |
| 3 | Outcome of untreated traumatic articular cartilage defects of the knee:a natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，85，2： | 1 |
| 4 | Leptin receptor expression in hindbrain Glp-1neurons regulates food intake and energy balance in mice显示文摘 | Michael S Kevin W Jari R | 2011 | J Clin Invest2011，121，24： | 1 |
| 5 | D dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage 显示文摘 | Seppo J Jari S | 2006 | Stroke2006，37，： | 1 |
| 6 | Increased inspired oxygen in the first hours of life is associated with adverse outcome in newborns treated for perinatal asphyxia with therapeutic hypothermia显示文摘 | Sabir H Jary S Tooley J | 2012 | J Pediatr2012，161，3： | 1 |
| 7 | High temperature enzymatic prehydrolysis prior to simultaneous saccharification and fermentation of steam pretreated corn stover for ethanol production显示文摘 | KARIN JARI V MATTI S | 2007 | Enzyme Microb Technol2007，40，4： | 1 |
| 8 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 9 | Research on the Shell-side Thermal Performances of Heat Exchangers with Helical Tube Coils显示文摘 | Geni'c S B Ja'cimovi'c B M Jari'c M S | 2012 | International Journal of Heat&Mass Transfer2012，55，1516： | 1 |
| 10 | Bovine Serum Albumin Decreases Km Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7and Increases Vmax Values of UGT1A9显示文摘 | Nenad M Paolo S M Jari Y K | 2011 | Drug Metab Dispos2011，39，11： | 1 |
| 11 | A Conceptual Model of Trust in the Online Environment显示文摘 | Jari S Heikki K | 2007 | Online Information Review2007，31，5： | 1 |
| 12 | Outcome of untreated traumatic articular cartilage defects of the knee:A natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，85，2： | 1 |
| 13 | Optimistic, defensive pessimistic, impulsive and self-handicapping strategies in university environments显示文摘 | SANNA E JARI E N KATARIINA S A | 1998 | Learn In- stru1998，8，： | 1 |
| 14 | Biomechanical function of surgical procedures for acromioclavicular joint dislo- cations显示文摘 | Jari R Costic R S Rodosky M W Debski R E | 2004 | Arthroscopy2004，20，： | 1 |
| 15 | Barrett’s esophagus: cancer and molecular biology显示文摘 | Michael K. Gibson Arashinder S. Dhaliwal Nicholas J. Clemons Wayne A. Phillips Katerina Dvorak Daniel Tong Simon Law E. Daniel Pirchi Jari R?s?nen Mark J. Krasna Kaushal Parikh Kausilia K. Krishnadath Yu Chen Leonard Griffiths Benjamin J. Colleypriest J. | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 16 | The effect of sterilisation on a poly(dimethylsiloxane)/poly (hexamethylene oxide) mixed macrodiolbased polyurethane elastomer显示文摘 | Anne S Jari H Laura P W | 2006 | Biomaterials2006，27，25： | 1 |
| 17 | Transaction costs and trading behavior in an immature water market显示文摘 | JARIS G DAVID L S DAVID Z | 2002 | Environment and Development Economics2002，，7： | 1 |
| 18 | Cloning and expression of poly 3-hydroxybutyrate operon into Escherichia coli 显示文摘 | Jari M Khatami S R Galehdari H Shafiei M | 2015 | Jundishapur Journal of Microbiology2015，8，16： | 1 |
| 19 | The role proprioception in shoulder instability 显示文摘 | Lephart M S Jari R | 2002 | Operat Tech Sports Med2002，10，： | 1 |
| 20 | C-reactive protein as predictor for poor outcome after aneuysmal subarachnoid haemorrhage显示文摘 | Juvela S Kuhmonen J Jari S | 2012 | Acta Neurochirurgica2012，154，154： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员