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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Common polymorphisms in the PPARγ2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men显示文摘 | Firoozeh Mousavinasab Tuula Thtinenc Jari Jokelainen | 2005 | Molr Genet Metabol2005，84，： | 1 |
| 3 | Outcome of untreated traumatic articular cartilage defects of the knee:a natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，852，： | 1 |
| 4 | Eigenmode method for electromagnetic synthesis of diffractive elements with three dimensional profiles显示文摘 | Eero N Jari T | 1994 | J Opt Soc Am A1994，11，9： | 1 |
| 5 | Inorganic hollow nanotube aerogels by atomic layer deposition onto native nanocellulose tem- plates显示文摘 | Korhonen J T Panu H Jari M | 2011 | Acs Nano2011，5，3： | 1 |
| 6 | Outcome of untreated traumatic articular cartilage defects of the knee:a natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，85，2： | 1 |
| 7 | Cryotherapy of shoot tips:novel pathogen eradi-cation method显示文摘 | Wang Q C Jari P T V | 2009 | Trends in Plant Science2009，14，3： | 1 |
| 8 | Detection of volatile organic compounds by desorption combined with mass spectrometry and Fourier transform infrared spectroscopy 显示文摘 | Ketola Raimo A Kiuru Jari T Tarkiainen Virpi | 2006 | Analytical ChimicaActa2006，562，2： | 1 |
| 9 | Unawareness in environmental protection ' the case of light pollution from traffic 显示文摘 | Jari L Petri T Timo A | 2012 | Land Use Policy2012，29，3： | 1 |
| 10 | Effect of experimental nitrogen load on methane and nitrous oxide fluxes on ombrotrophic boreal peatland 显示文摘 | Haanu Nyknen Harri Vasander Jari T Huttunen | 2002 | Plant and Soil2002，242，： | 1 |
| 11 | Outcome of untreated traumatic articular cartilage defects of the knee:A natural history study显示文摘 | Shelbourne KD Jari S Gray T | 2003 | J Bone Joint Surg Am2003，85，2： | 1 |
| 12 | Peripheral pathways regulate motomeuron collateral dynamics显示文摘 | Redett R Jari R Crawford T | 2005 | J Neurosci2005，25，41： | 1 |
| 13 | Unconven- tional shale- gas system:The Mississippan Bar- nett Shale of north-central Tex as one model for thermogenic shale- gas assessment显示文摘 | Jarie D M Hill R J Ruble T E et aI | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 14 | Associated weights and spaces of holomorphic functions显示文摘 | KLAUS D B JOSE B JARI T | 1988 | Studia Math1988，127，2： | 1 |
| 15 | Cryotherapy of shoot tips:novd pathogen eradication method 显示文摘 | Wang Q C Jari P T Valkonen | 2008 | Trends in Plant Science2008，14，3： | 1 |
| 16 | Peripheral path- ways regulate motoneuron collateral dynamics显示文摘 | REDETT R JARI R CRAWFORD T | 2005 | The Journal of Neuroscience2005，25，41： | 1 |
| 17 | Subcritical water as eluent for chromatographic separation of carbohydrates using cation - exchange resins显示文摘 | Jari T Eeva LP Marko L K | 2005 | Sep Purif Technol2005，44，2： | 1 |
| 18 | Accurate measurement of low insulator contamination levels显示文摘 | Chisholm W A Buchan P G Jary T | 1994 | IEEE Transactions on Power Delivery1994，9，3： | 1 |
| 19 | The reliability distribution arid respon- siveness of the postural control and balance for stroke test显示文摘 | Outi P Ulla T Jari V | 2005 | Arch Physic Med Rehabilitat2005，86，2： | 1 |
| 20 | The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis 显示文摘 | Jari T Kristian W Vesa K | 2009 | Schizophrenia Res2009，109，13： | 1 |
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