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| 1 | Genetic epidemiology of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(C-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS. | Jasbir Makker Sridhar Chilimuri Jonathan N Bella | 2015 | World Journal of Gastroenterology2015，21，40： | 20 |
| 2 | Discrete element method study of shear-driven granular segregation in a slowly rotating horizontal drum显示文摘 | Ram Chand Sithi V. Muniandy Chiow San Wong Jasbir Singh | 2017 | Particuology2017，15，3： | 4 |
| 3 | ESSENTIAL NORMS OF PRODUCTS OF WEIGHTED COMPOSITION OPERATORS AND DIFFERENTIATION OPERATORS BETWEEN BANACH SPACES OF ANALYTIC FUNCTIONS显示文摘We obtain several estimates of the essential norms of the products of differentiation operators and weighted composition operators between weighted Banach spaces of analytic functions with general weights.As applications,we also give estimates of the essential norms of weighted composition operators between weighted Banach space of analytic functions and Bloch-type spaces. | Jasbir Singh MANHAS Ruhan ZHAO | 2015 | Acta Mathematica Scientia2015，35，6： | 3 |
| 4 | Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool显示文摘AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities. | Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
| 5 | Circadian regulation of Limulus visual functions:A role for octopamine and cAMP显示文摘The purpose of this contribution is to review our current understanding of the source and biochemistry of the circadianefferent input to the eyes of the American horseshoe crab Limulus polyphemus and the impact of this input on the structure,physiology and biochemistry of Limulus eyes. Special emphasis is given to the role of the biogenic amine octopamine and biochemicalcascades it activates in the eyes. In addition to reviewing published data, we present new data showing that octopamineelevates cAMP levels in Limulus lateral eyes, and we partially characterize the pharmacology of the receptors involved in this response.We also present new data showing that octopamine regulates gene expression in Limulus lateral eyes by activating acAMP | Jasbir S.DALAL Barbara-Anne BATTELLE | 2010 | Current Zoology2010，56，5： | 3 |
| 6 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 7 | An Investigation of resource - based and institutional theoretic factors in technology adoption for operations and supply chain management 显示文摘 | JASBIR D CHENG Z | 2013 | International Journal of Production and Economic2013，120，1： | 1 |
| 8 | Two algorithms for global optimization of general NLP problems显示文摘 | Elwakeil O A Jasbir Arora S | 1996 | International Journal for numerical Methods in Engineering1996，39，： | 1 |
| 9 | A Reversed Context Analysis of Software Piracy Issues in Singapore 显示文摘 | TREVOR MOORES JASBIR DHALIWAL | 2004 | Information & Management2004，41，： | 1 |
| 10 | Two algorithms for global optimization of general NLP problems显示文摘 | Ossarna A E Jasbir A S | 1996 | International Journal for numerical Methods in Engineering1996，，39： | 1 |
| 11 | A review of optimization of structures subjected to transient loads显示文摘 | Byung-Soo Kang Gyung-Jin Park Jasbir S. Arora | 2006 | Structural and Multidisciplinary Optimization2006，，2： | 1 |
| 12 | Failure criterion for RC members under biaxial bending and axial load显示文摘 | MARCELO A S COLBY C S jASBIR S A REYOLANDO M | 2001 | Journal of Structural Engineering2001，127，8： | 1 |
| 13 | Assimilation and diffusion of web technologies in supply - chain management : an examination of key drivers and perform- ance impacts 显示文摘 | Ranganathan C Jasbir S D Thompson S H T | 2004 | International Journal of Electronic Commerce2004，9，1： | 1 |
| 14 | An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents显示文摘 | Kamaljit Singh Jasbir Singh Prasant K Deb | 1999 | Tetrahedron1999，55，12： | 1 |
| 15 | Superoxide-dependent formation of hydroxyl radicals:detection of hydroxyl radicals by the hydroxylation for aromatic compounds显示文摘 | Ramsay Richmond Barry Halliwell Jasbir Chauhan | 1981 | Analytical Biochemistry1981，118，2： | 1 |
| 16 | Structural data for the carbohydrate of ispaghula husk of Plantago ovata Forsk显示文摘 | John F Kennedy rederick Jasbir S Sandhu | 1979 | Carbohydrate Research1979，75，： | 1 |
| 17 | Dexme-detomidine and clonidine in epidural anaesthesia: A comparative eval-uation显示文摘 | SUKHMINDER J’ SUKHWINDER K B JASBIR K | 2011 | Indian J Anaesth2011，55，1： | 1 |
| 18 | Assimilation and diffusion of web technologies in supply-chain management:an examination of key drivers and performance impacts显示文摘 | Ranganathan C Jasbir S Dhaliwal Thompson S H Teo | 2004 | International Journal of Electronic Commerce2004，9，1： | 1 |
| 19 | A novel inhibitor for scale control in water desalination显示文摘 | Jasbir S G | 1999 | Desalination1999，124，1： | 1 |
| 20 | Dexmedetomi-dine and clonidine in epidural anaesthesia:A comparative evalua-tion显示文摘 | Sukhminder JSB Sukhwinder KB Jasbir K | 2011 | Indian J Anaesth2011，55，2： | 1 |
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