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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 3 | Goldmanlmage seg-mentation evaluation: A survey of unsupervised methods 显示文摘 | ZHANG Hui JASON E FRITTS B | 2008 | Computer Vision anti Image Understandin2008，110，2： | 1 |
| 4 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 5 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 6 | Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fine needle aspiration显示文摘 | Jason B Klapman Roberto Logrono Charles E Dye Irving Waxman | 2003 | The American Journal of Gastroenterology2003，，6： | 1 |
| 7 | Optimal struc- ture, market dynamism, and the strategy of simple rules显示文摘 | Jason P D Kathleen M E Bingham C B | 2009 | Administrative Science Quarterly2009，54，3： | 1 |
| 8 | Solvent effects on copper nanoparticle growth behavior in AOT reverse micelle Systems显示文摘 | Joanna P C Michael E M Jason B T | 2001 | Phys ChemB2001，105，12： | 1 |
| 9 | Optima/ structure, market dynamism, and the strategy of simple rules 显示文摘 | JASON P D KATHLEEN M E CHRISTOPHER B B | 2009 | Administrative Science Quarterly2009，，9： | 1 |
| 10 | Transient modeling of high- altitude rocket-stage separation 显示文摘 | Allen E Jason C Matthew B | 2008 | Journal of Spacecraft and Rockets2008，45，4： | 1 |
| 11 | GoldmanImage segmentation evaluation : A survey of unsupervised methods显示文摘 | Zhang Hui Jason E Fritts B | 2008 | Computer Vi- sion and Image Understandin2008，110，2： | 1 |
| 12 | Systematic analysis of bacterialeffectorpostsynaptic density 95/disc large/zonula occludens-1(PDZ)domain interactions demonstrates Shigella Osp E proteinpromotes protein kinase C activation via PDLIM proteins显示文摘 | Chae-ryun Yi John E Allen Brian Russo Soo Young Lee Jason E Heindl Leigh A Baxt Bobby Brooke Herrera Emily Kahoud Gavin Mac Beath Marcia B Goldberg | 2014 | The Journal of biological chemistry2014，289，30： | 1 |
| 13 | Greenland ice sheet surface mass balance variability (1998-2004) from calibrated polar MM5 output显示文摘 | Jason E B David H B Bruce A | 2006 | Journal of Climate2006，19，： | 1 |
| 14 | Goldman image segmentation evaluation:a survey of unsupervised methods显示文摘 | ZHANG Hui JASON E FRITTS B | 2008 | Computer Vision and Image Understanding2008，110，2： | 1 |
| 15 | Enhanced CO2 separation selectivity in oligo (ethylene glycol) functionalized room-temperature ionic liquids显示文摘 | JASON E B CHRISTOPHER J G SONJA L | 2007 | Ind Eng Chem Res2007，46，16： | 1 |
| 16 | Lattiee-Boltzmann Sim- ulations of the Dynamics of Polymer Solutions in Periodic and Confined Geometries 显示文摘 | Usta O B AnthonyJ C Jason E | 2005 | 3 Chem Phys2005，122，09： | 1 |
| 17 | Growth with endogenous risk of biological invasion显示文摘 | BARBIER E B JASON F S | 2004 | Econ Inq2004，42，4： | 1 |
| 18 | 显示文摘 | Jason E Riggs David B Walken David L Carroll | 2000 | J Phys Chem B2000，104，： | 1 |
| 19 | GoldmanImage segmentation evaluation: A survey of unsupervised methods 显示文摘 | Zhang Hui Jason E Fritts B | 2008 | Computer Vision and Image Understanding2008，110，2： | 1 |
| 20 | Measurements of Thermal Gradient and Their Effects on Segmental Concrete Bridge显示文摘 | Carin L R-W John E B Jason C | 2002 | Journal of Bridge Engineering2002，7，3： | 1 |
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