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9篇 您的检索式：作者名="Jason Roland"

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		题名	作者	年代	出处	被引量
	1	Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans显示文摘	Vimal K. Narula Lynn C. Happel Kevin Volt Simon Bergman Jason C. Roland Rebecca Dettorre David B. Renton Kevin M. Reavis Bradley J. Needleman Dean J. Mikami E. Christopher Ellison W. Scott Melvin Jeffrey W. Hazey	2009	Surgical Endoscopy2009，，6：	2
	2	Discrimination between climate and human-induced dryland degradation显示文摘	Jason Evans Roland Geerken	2004	Journal of Arid Environments2004，，57：	1
	3	Discrimination between climate and human-induced dryland degradation 显示文摘	JASON E ROLAND G G	2004	Journal of Arid Environments2004，57，：	1
	4	Discrimination between climate and human-induced dryland degradation显示文摘	Jason Evans Roland Geerken	2003	Journal of Arid Environments2003，，4：	1
	5	Discrimination between climate and human-induced dryland degradation显示文摘	Jason Evans Roland Geerken	2003	Journal of Arid Environments2003，，4：	1
	6	Endovascular Management of a Splenic Artery Aneurysm显示文摘	Jason Roland Fred Brody Anthony Venbrux	2007	Surgical Laparoscopy Endoscopy & Percutaneous Techniques2007，，5：	1
	7	The Ser/Thr kinase activity of the Yersinia protein kinase A (YpkA) is necessary for full virulence in the mouse, mollifying phagocytes, and disrupting the eukaryotic cytoskeleton显示文摘	David J. Wiley Roland Nordfeldth Jason Rosenzweig Christopher J. DaFonseca Richard Gustin Hans Wolf-Watz Kurt Schesser	2006	Microbial Pathogenesis2006，，：	1
	8	A small molecule UPR modulator for diabetes identified by high throughput screening显示文摘Unfolded protein response(UPR) is a stress response that is specific to the endoplasmic reticulum(ER).UPR is activated upon accumulation of unfolded(or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones.In addition,UPR also enhances degradation of unfolded proteins and reduces global protein synthesis to alleviate additional accumulation of unfolded proteins in the ER.Herein,we describe a cell-based ultra-high throughput screening(uHTS) campaign that identifies a small molecule that can modulate UPR and ER stress in cellular and in vivo disease models.Using asialoglycoprotein receptor 1(ASGR) fused with Cypridina luciferase(CLuc) as reporter assay for folding capacity,we have screened a million small molecule library and identified APC655 as a potent activator of protein folding,that appears to act by promoting chaperone expression.Furthermore,APC655 improved pancreatic β cell viability and insulin secretion under ER stress conditions induced by thapsigargin or cytokines.APC655 was also effective in preserving β cell function and decreasing lipid accumulation in the liver of the leptin-deficient(ob/ob) mouse model.These results demonstrate a successful uHTS campaign that identified a modulator of UPR,which can provide a novel candidate for potential therapeutic development for a host of metabolic diseases.	Valeria Marrocco Tuan Tran Siying Zhu Seung Hyuk Choi Ana M.Gamo Sijia Li Qiangwei Fu Marta Diez Cunado Jason Roland Mitch Hull Van Nguyen-Tran Sean Joseph Arnab K.Chatterjee Nikki Rogers Matthew S.Tremblay Weijun Shen	2021	Acta Pharmaceutica Sinica B2021，11，12：	1
	9	Neoadjuvant Chemotherapy in Stage IB2 Squamous Cell Carcinoma of the Cervix显示文摘	Eli Serur Roland P. Mathews Jason Gates Phyllis Levine Mitchell Maiman Jean Claude Remy	1997	Gynecologic Oncology1997，，2：	1

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