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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | Using events as a mapping concept that complement existing ROS methods显示文摘 | Chad D PierskaUaa Jason M Siniscalchia Steven W Selina | 2007 | Leisure Sciences2007，29，1： | 1 |
| 5 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 6 | Computational identification of cis-regulatory elements associated groups of functionaily related genes in Saccharomyces cetevisiae显示文摘 | Jason D Hughes Preston W Estep Saeed Tavazoie George M Church | 2000 | J Mol Biol2000，296，5： | 1 |
| 7 | Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction显示文摘 | Wu M F Tian Q Jason W R | 2006 | Development2006，133，： | 1 |
| 8 | 3,4-Dihydropyri- midin-2 ( 1 H) -ones positive modulation of ~-subunit-eon- raining y-aminobutyrie acid type a receptors,including an epilepsy-link ed mutant variant 显示文摘 | RYAN W L JOHN M JASON G | 2010 | Bioehernistry2010，49，23： | 1 |
| 9 | The contribution of genetic resources and diversity to wheat production in the Punjab of Pakistan显示文摘 | Smale M Jason H Paul W H | 1998 | American Journal of Agricultural Economics1998，80，： | 1 |
| 10 | Formation and control of box-shaped ultra-shallow junction using laser annealing and pre-amorphization implantation显示文摘 | Kim S D Park C M Jason C S W | 2005 | Solid-State Electronics2005，49，1： | 1 |
| 11 | Housebold knowledge,attitudes and practices related to pet contact and associated zoonoses in Ontario,Canada显示文摘 | JASON W S L ANDREW S P JAN M S | 2012 | BMC Public Health2012，12，： | 1 |
| 12 | On the persistence of Cenococcum geophilum ectomycorrhizas and its implications for forest carbon and nutrient cycles显示文摘 | CHRISTOPHER W F LUKE M M JASON M H | 2013 | Soil biology & biochemistry2013，65，： | 1 |
| 13 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 14 | The contribution ofgenetic resources and diversity to wheat production in thePunjab of Pakistan显示文摘 | Smale M Jason H Paul W H Ben S | 1998 | American Journal of AgriculturalEconomics1998，80，： | 1 |
| 15 | The Chlamydomonas reinhardtii plastid chromosome: islands of genes in a sea of repeats显示文摘 | Jude E M Jason W L Cui Liying | 2002 | The Plant Cell2002，14，： | 1 |
| 16 | Devel- opment and application of a muhimodal contrast ggent for SPECT/CT hybrid imaging 显示文摘 | Jason M C Lawrence W D Zhen W Z etal | 2011 | Bioconjug Chem2011，22，： | 1 |
| 17 | Invariant Manifold Tracking for First - Order Nonlinear Hill's Equations 显示文摘 | W M Jason | 2003 | Journal of Guidance Control and Dynamics2003，16，14： | 1 |
| 18 | A summary of eleven years progress in earthworm ecotoxicology:the 7th international symposium on earthworm ecology Cardiff Wales 2002显示文摘 | DAVIDJS JASON M W CORNELIUS A M | | 0，，5： | 1 |
| 19 | The contribution ofgenetic resources and diversity to wheat production in the Pun- jab of Pakistan 显示文摘 | Smale M Jason H Paul W H Ben S | 1998 | American Journal of Agricultural Eco- nomics1998，80，： | 1 |
| 20 | Surface passivation of bare aluminum nanoparticles using perfluoroalkyl carboxylic acids 显示文摘 | Jason J R Andrea D W David M R | 2005 | Chem Mater2005，，17： | 1 |
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