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| 1 | APASL consensus statements and management algorithms for hepatitis C virus infection显示文摘 | Masao Omata Tatsuo Kanda Ming-Lung Yu Osamu Yokosuka Seng-Gee Lim Wasim Jafri Ryosuke Tateishi Saeed S. Hamid Wan-Long Chuang Anuchit Chutaputti Lai Wei Jose Sollano Shiv Kumar Sarin Jia-Horng Kao Geoffrey W. McCaughan | 2012 | Hepatology International2012，，2： | 8 |
| 2 | Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation显示文摘AIM: To investigate over-expression of Osteopontin(OPN) pathway expression and mechanisms of action in human alcoholic liver disease(ALD), in vivo and in vitro acute alcohol models. METHODS: OPN pathway was evaluated in livers from patients with progressive stages of human ALD and serum from drinkers with and without liver cirrhosis. In vitro stellate LX2 cells exposed to acute alcohol and in vivo in acute alcoholic steatosis mouse models were also investigated for OPN pathway expression and function. WT and OPN-/- mice were administered an acute dose of alcohol and extent of liver injury was examined by histopathology and liver biochemistry after 16-24 h. The causative role of OPN was studied in OPN knockout animals and in vitro in stellate LX2 cells, utilizing siRNA, aptamer and neutralizing antibodies to block OPN and OPN pathway. OPN pathway expression and downstream functional consequences were measured for signaling by Western blotting, plasmin activation by spectrophotometric assays and cell migration by confocal imaging and quantitation. RESULTS: OPN expression positively correlated with disease severity in patients with progressive stages of ALD. In vivo, associated with alcoholic steatosis, a single dose of acute alcohol significantly increased hepatic OPN mRNA and protein, and a cleaved OPN form in a dose dependent manner. OPN mRNA and secreted OPN also increased in parallel with activation of LX2 stellate cells within 4 h of a single dose of alcohol. Expression of OPN receptors, αvβ3-integrin and CD44, increased in human ALD, and in vivo and in vitro with alcohol administration. This was accompanied by downstream phosphorylation of Akt and Erk, increased mRNA expression of several fibrogenesis, fibrinolysis and extracellular matrix pathway genes, plasmin activation and hepatic stellate cell(HSC) migration. Inhibition of OPN and OPN-receptor mediated signaling partially inhibited alcohol-induced HSC activation, plasmin activity and cell migration. CONCLUSION: OPN is a key mediator of the alcoholinduced effects on hepatic stellate cell functions and liver fibrogenesis. | Devanshi Seth Alastair Duly Paul C Kuo Geoffrey W McCaughan Paul S Haber | 2014 | World Journal of Gastroenterology2014，20，36： | 5 |
| 3 | APASL consensus statements and management algorithms for hepatitis C virus infection显示文摘 | Masao Omata Tatsuo Kanda Ming-Lung Yu Osamu Yokosuka Seng-Gee Lim Wasim Jafri Ryosuke Tateishi Saeed S. Hamid Wan-Long Chuang Anuchit Chutaputti Lai Wei Jose Sollano Shiv Kumar Sarin Jia-Horng Kao Geoffrey W. McCaughan | 2012 | Hepatology International2012，，2： | 3 |
| 4 | O68 SOFOSBUVIR AND RIBAVIRIN FOR THE TREATMENT OF CHRONIC HCV WITH CIRRHOSIS AND PORTAL HYPERTENSION WITH AND WITHOUT DECOMPENSATION: EARLY VIROLOGIC RESPONSE AND SAFETY显示文摘 | N. Afdhal G. Everson J.L. Calleja G. McCaughan W.T. Symonds J. Denning L. McNair J.G. McHutchison S. Arterburn M. Charlton R. Reddy T. Asselah E. Gane X. Forns | 2014 | Journal of Hepatology2014，，1： | 3 |
| 5 | Update on the management of the gastrointestinal effects of radiation显示文摘Radiation therapy is a long-established and essential modality in the treatment of many cancers.It is well known that tissue within a field of radiation can suffer indiscriminate effects,leading to acute and chronic problems.The gastrointestinal tract may be adversely affected by radiation.From the mouth to the rectum,patients can experience troublesome symptoms that require the concerted input of specialist teams.Interventions range from nursing care,dietetic optimization,pharmacological management,and mechanical procedures through endoscopy and surgery.Quality evidence exists mainly for radiation induced effects in four distinct areas of the gastrointestinal tract:oral mucosa,esophagus,small bowel,and rectum.This review explores the experiences of oncology and gastrointestinal teams in managing the most common conditions and some of the different practices for radiation associated morbidity. | Hannah McCaughan Stephen Boyle John J McGoran | 2021 | World Journal of Gastrointestinal Oncology2021，13，5： | 2 |
| 6 | Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis显示文摘 | Paul S. Haber Gregory W. Keogh Minoti V. Apte Corey S. Moran Nancy L. Stewart Darrell H.G. Crawford Romano C. Pirola Geoffrey W. McCaughan Grant A. Ramm Jeremy S. Wilson | 1999 | The American Journal of Pathology1999，，4： | 2 |
| 7 | De novo Cancer‐Related Death in Australian Liver and Cardiothoracic Transplant Recipients显示文摘 | R. Na A. E. Grulich N. S. Meagher G. W. McCaughan A. M. Keogh C. M. Vajdic | 2013 | American Journal of Transplantation2013，，5： | 2 |
| 8 | Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing显示文摘 | Wendy S.C. Cheng Stuart K. Roberts Geoffrey McCaughan William Sievert Martin Weltman Darrell Crawford William Rawlinson Philippa S. Marks James Thommes Bishoy Rizkalla Motoko Yoshihara Gregory J Dore | 2010 | Journal of Hepatology2010，，4： | 2 |
| 9 | Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection显示文摘 | Matthew T. Kitson Gregory J. Dore Jacob George Peter Button Geoffrey W. McCaughan Darrell H.G. Crawford William Sievert Martin D. Weltman Wendy S. Cheng Stuart K. Roberts | 2012 | Journal of Hepatology2012，，： | 2 |
| 10 | Comparison of De Novo Cancer Incidence in Australian Liver, Heart and Lung Transplant Recipients显示文摘 | R. Na A. E. Grulich N. S. Meagher G. W. McCaughan A. M. Keogh C. M. Vajdic | 2012 | American Journal of Transplantation2012，，1： | 2 |
| 11 | <ce:link locator='fx1'/> Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 2 |
| 12 | Application of Bifurcation Theory to Axial Flow Compressor Instability 显示文摘 | McCaughan F E | 1989 | Journal of Turbo Machinery1989，111，： | 2 |
| 13 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 14 | East meets West: acute liver failure in the global village显示文摘 | Bowen DG Shackel NA Mccaughan GW | 2000 | J Gastroenterol Hepatol2000，15，5： | 1 |
| 15 | Combination lowdose hepatitis B immune globulin and lamivudine therapy provides effective prophylaxis against posttransplantation hepatitis B显示文摘 | Angus PW McCaughan GW Gane EJ | 2000 | Liver Transpl2000，6，4： | 1 |
| 16 | Minimally invasive esophagectomy:outcomes in,222 patients显示文摘 | Luketich JD Alvolo-Rivera M Buenaventura PO Christie NA McCaughan JS Litle VR | | 0，，： | 1 |
| 17 | Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 1 |
| 18 | Thymoma: trends over time显示文摘 | Katrina H Moore Paul R McKenzie Catherine W Kennedy Brian C McCaughan | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 19 | Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer显示文摘 | McCaughan F Pole JC Bankier AT | 2010 | Am J Respir Crit Care Med2010，182，1： | 1 |
| 20 | Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for earlystage non-small-cell lung cancer 显示文摘 | Yan TD Black D Bannon PG Mccaughan BC | 2009 | J Clin Oncol2009，27，15： | 1 |
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