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| 1 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 2 | Visual object tracking- classical and contemporary approaches显示文摘 | Ahmad ALI Abdul JALIL Jianwei NIU Xiaoke ZHAO Saima RATHORE Javed AHMED Muhammad AKSAM IFTIKHAR | 2016 | Frontiers of Computer Science2016，10，1： | 7 |
| 3 | Stretching a Curved Surface in a Viscous Fluid显示文摘这个工作涉及粘滞由于弄弯的拉长流动表。这个问题的类似答案被一个射击方法用 RungeKutta 算法数字地获得。象液体速度和皮肤磨擦系数一样的兴趣的物理数量在无尺寸的弯曲的影响下面被获得并且讨论。它从那无尺寸的弯曲在皮肤磨擦系数在边界层厚度和减少引起增加的结果是明显的。 | M. Sajid N. Ali T. Javed Z. Abbas | 2010 | Chinese Physics Letters2010，27，2： | 4 |
| 4 | Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer显示文摘The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the globe.In many cases,BC becomes resistant to chemotherapy,radiation and hormonal therapies.Traditional BC therapies are associated with adverse side effects,drug resistance and recurrence.Extensive research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against BC.We have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo models.We have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC miRNAs.Finally,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed. | Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 3 |
| 5 | Analysis of the effect of passive measures on the energy consumption and zero-energy prospects of residential buildings in Pakistan显示文摘Climate change can adversely impact the thermal comfort and energy efficiency of the buildings stock. The South Asian countries are particularly vulnerable to the adverse impacts of climate change specially in the form of rising temperatures and increasing frequency of heat waves. The passive building design measures can be useful in mitigating and adapting to the climate change by increasing energy efficiency and reducing greenhouse gas (GHG) emissions. In this study various passive climate change adaptation measures (PCAMs) have been used individually and in form of combinations in order to analyze their impact on the energy efficacy of residential buildings in Pakistan. It has been found that the natural ventilation and front green wall are the most efficient options for reducing the overall energy consumption. By implementation of these PCAMs, cooling demand can be decreased by 27.75% while heating demand can be reduced by 35%. Secondly, the prospect of net zero-energy building and reduced CO2 emissions are also studied. It has been shown that building can achieve net-zero energy on an annual basis at every orientation and it can attain the status of nearly zero-energy building on a monthly basis. Moreover, emitted CO2 can be reduced by 31% by using the renewable energy. | Muhammad Wasim Anwar Zaib Ali Abdullah Javed Emad Ud Din Muhammad Sajid | 2021 | Building Simulation2021，14，4： | 3 |
| 6 | A Reliable Stochastic Numerical Analysis for Typhoid Fever Incorporating With Protection Against Infection显示文摘In this paper,a reliable stochastic numerical analysis for typhoid fever incorporating with protection against infection has been considered.We have compared the solutions of stochastic and deterministic typhoid fever model.It has been shown that the stochastic typhoid fever model is more realistic as compared to the deterministic typhoid fever model.The effect of threshold number T*hold in stochastic typhoid fever model.The proposed framework of the stochastic non-standard finite difference scheme(SNSFD)preserves all dynamical properties like positivity,bounded-ness and dynamical consistency defined by Mickens,R.E.The stochastic numerical simulation of the model showed that increase in protection leads to low disease prevalence in a population. | Muhammad Shoaib Arif Ali Raza Muhammad Rafiq Mairaj Bibi Rabia Fayyaz Mehvish Naz Umer Javed | 2019 | Computers, Materials & Continua2019，，6： | 3 |
| 7 | Predictions of future hydrological conditions and contribution of snow and ice melt in total discharge of Shigar River Basin in Central Karakoram,Pakistan显示文摘The high mountains of Hindu-Kush Karakoram and Himalaya(HKKH) contain a large volume of snow and ice, which are the primary sources of water for the entire mountainous population of HKKH. Thus, knowledge of these available resources is very important in relation to their sustainable use. A Modified Positive Degree Day Model was used to simulate daily discharge with the contribution of snow and ice melt from the Shigar River Basin, Central Karakoram, Pakistan. The basin covers an area of 6,921 km2 with an elevation range of 2,204 to 8,611 m a.s.l.. Forty percent of the total area is glaciated among which 20% is covered by debris and remaining 80% by clean ice and permanent snow. To simulate daily discharge, the entire basin was divided into 26 altitude belts. Remotely sensed land cover types are derived by classifying Landsat images of 2009. Daily temperature and precipitation from Skardu meteorological station is used to calibrate the glacio-hydrological model as an input variable after correlating data with the Shigar station data(r=0.88). Local temperature lapse rate of 0.0075 °C/m is used. 2 °C critical temperature is used to separate rain and snow from precipitation. The model is calibrated for 1988~1991 and validated for 1992~1997. The model shows a good Nash-Sutcliffe efficiency and volume difference in calibration(0.86% and 0.90%) and validation(0.78% and 6.85%). Contribution of snow and ice melt in discharge is 32.37% in calibration period and 33.01% is validation period. The model is also used to predict future hydrological regime up to 2099 by using CORDEX South Asia RCM considering RCP4.5 and RCP8.5 climate scenarios.Predicted future snow and ice melt contributions in both RCP4.5 and RCP8.5 are 36% and 37%, respectively. Temperature seems to be more sensitive as compared to other input variables, which is why the contribution of snow and ice in discharge varies significantly throughout the whole century. | Javed Hassan Rijan Bhakta Kayastha Ahuti Shrestha Iram Bano Sayed Hammad Ali Haleem Zaman Magsi | 2017 | Research in Cold and Arid Regions2017，9，6： | 3 |
| 8 | Left‐sided hepatic resection for hepatolithiasis: a longitudinal study of 110 patients显示文摘 | Omar Javed Shah Irfan Robbani Parveen Shah Showkat Ali Zargar Gul Javaid Ghulam N Yattoo Altaf Shah Farhat Mustafa | 2012 | HPB2012，，11： | 2 |
| 9 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 10 | Spatial Trend of Foot and Mouth Disease Virus (FMDV) Serotypes in Cattle and Buffaloes, Pakistan显示文摘The present study describes the frequency of Foot and Mouth Disease (FMD) virus serotypes (O, A and Asia-1) in major regions (all provinces) of Pakistan using Indirect Sandwich ELISA. Also, spatial distribution of various FMD serotypes and their comparison is discussed. A total of 590 samples (Epithelial tissue) have been analyzed during a period of five years (2005-2009). Out of 590 samples, 180 were found positive, giving an overall confirmation of FMDV about 33.2 %. Of the prevalent serotypes, FMDV 'O' serotype caused most outbreaks (20.7 %), followed by serotype A (6.6 %) and serotype Asia-1 (4.6 %) while there was no positive case of type 'C'. The study clearly showed that the disease was more frequent in the agro-climatic zones than in hilly areas. Based on the data of 590 samples (>50 outbreaks), the overall prevalence of FMDV in cattle and buffaloes in Pakistan was 33.2 %, while in cattle alone, it was 37.1 %, higher than in buffalo (28.7 %). There were eight cases of mixed serotypes infection, indicating the presence of endemic state of disease. Another significant feature was the change over time. In phase-I (2005-2007), there was an overall prevalence of 29.4 %, while the occurrence of the serotype O, A and Asia-1 was 20.4 %, 2.9 % and 4.7 %, respectively. During phase-II (2008-2009), the overall prevalence was 59.21 %, while those of serotype O, A and Asia-1 were 22.4 %, 31.6 % and 4.0 %, respectively. This clearly indicated a shift from serotype O to A, which may help to explain the occurrence of more severe outbreaks, despite vaccination. | Muhammad Abubakar Muhammad Javed Arshed Qurban Ali Manzoor Hussain | 2012 | Virologica Sinica2012，27，5： | 2 |
| 11 | A Molecular Approach for Genotyping of Hepatitis B Virus Using Restriction Pattern Analysis of S Amplicon in Pakistan显示文摘 | Nazish Badar Umer Farooq Shafaqat Ali Nadia Nisar Muhammad Abubakar Javed Anwar Qureshi | 2012 | 世界最新医学信息文摘2012，12，3： | 2 |
| 12 | Enzymes used in detergents: Lipases 显示文摘 | Hasan F Ali Shah A Javed S | 2010 | African Journal of Biotechnology2010，9，31： | 1 |
| 13 | MHD peristaltic transport of a Jeffrey fluid in a channel with compliant walls and porous space显示文摘 | Hayat T Javed M Ali N | 2008 | Transp Porous Med2008，74，3： | 1 |
| 14 | Short term incubation of sorghum caryopses in sodium chloride levels: changes in some pre- and post-germination physiological parameters显示文摘 | Abdul Wahid Intshar-ul-Haq Javed Iftikhar Ali Anila Baig Ejaz Rasul | 1998 | Plant Science1998，，2： | 1 |
| 15 | Prevalent fecal contamination in drinking water resources and potential health risks in Swat, Pakistan显示文摘Fecal bacteria contaminate water resources and result in associated waterborne diseases.This study assessed drinking water quality and evaluated their potential health risks in Swat, Pakistan. Ground and surface drinking water were randomly collected from upstream to downstream in the River Swat watershed and analyzed for fecal contamination using fecal indicator bacteria(Escherichia coli) and physiochemical parameters(potential of hydrogen, turbidity, temperature, electrical conductivity, total dissolved solid, color, odor and taste). The physiochemical parameters were within their safe limits except in a few locations, whereas, the fecal contaminations in drinking water resources exceeded the drinking water quality standards of Pakistan Environmental Protection Agency(Pak-EPA),2008 and World Health Organization(WHO), 2011. Multivariate and univariate analyses revealed that downstream urbanization trend, minimum distance between water sources and pit latrines/sewerage systems, raw sewage deep well injection and amplified urban,pastures and agricultural runoffs having human and animal excreta were the possible sources of contamination. The questionnaire survey revealed that majority of the local people using 10–20 years old drinking water supply schemes at the rate of 73% well supply,13% hand pump supply, 11% spring supply and 3% river/streams supply, which spreads high prevalence of water borne diseases including hepatitis, intestinal infections and diarrhea, dysentery, cholera, typhoid fever, jaundice and skin diseases in children followed by older and younger adults. | Kifayatullah Khan Yonglong Lu Mian Abdal Saeed Hazrat Bilal Hassan Sher Hizbullah Khan Jafar Ali Pei Wang Herman Uwizeyimana Yvette Baninla Qifeng Li Zhaoyang Liu Javed Nawab Yunqiao Zhou Chao Su Ruoyu Liang | 2018 | Journal of Environmental Sciences2018，30，10： | 1 |
| 16 | Quantification of Urban Sprawl for Past-To-Future in Abha City,Saudi Arabia显示文摘Given that many cities in Saudi Arabia have been observing rapid urbanization since the 1990s,scarce studies on the spatial pattern of urban expansion in Saudi Arabia have been conducted.Therefore,the present study investigates the evidence of land use and land cover(LULC)dynamics and urban sprawl in Abha City of Saudi Arabia,which has been experiencing rapid urbanization,from the past to the future using novel and sophisticated methods.The SVM classifier was used in this study to classify the LULC maps for 1990,2000,and 2018.The LULC dynamics between 1990–2000,2000–2018,and 1990–2018 have been analyzed using delta()change and the Markovian transitional probability matrix.Urban sprawl or urban expansion was modeled using two approaches,such as landscape fragmentation and presence frequency for the first time.The future LULC map for 2028 was predicted using the artificial neural network-cellular automata model(ANN-CA).Future LULC was analyzed using landscape fragmentation and frequency approaches.The results of LULC maps showed that urban areas increased by 334.4%between 1990 and 2018.The Delta change rate showed that 16.34%in urban areas has increased since 1990.While,the transitional probability matrix between 1990 and 2018 reported that the built-up area is the largest stable LULC,having an 83.6%transitional probability value.While 17.9%,21.8%,12.4%,and 10.5%of agricultural land,scrubland,exposed rocks,and water bodies were transformed into built-up areas.Urban sprawl models showed that 139 km^(2)of new urban areas had been set up in 2018,49 and 69 km^(2)in 1990 and 2000.Furthermore,in 2018,more than 200%of urban areas were stabilized or became core urban areas.The future LULC map(2028)showed that the built-up area would be 343.72 km^(2),followed by scrubland(342.98 km^(2))and sparse vegetation(89.96 km^(2)).The new urban area in 2028 would be 169 km^(2).The authorities and planners should focus more on the sustainable development of urban areas;otherwise,it would harm the natural and urban environment. | Saeed AlQadhi Javed Mallick Swapan Talukdar Ahmed Ali Bindajam Ahmed Ali A.Shohan Shahfahad | 2021 | Computer Modeling in Engineering & Sciences2021，，11： | 1 |
| 17 | Optimization of fermentation parameters for higher lovastatin production in red mold rice through co-culture of Monascus purureus and Monascus ruber显示文摘 | Panda B P Javed S Ali M | 2008 | Food and Bioprocess Technology2008，3，3： | 1 |
| 18 | Formation of crystalline particles from phase change emulsion: Influence of different parameters显示文摘Solidification or crystallization of phase change emulsion in the form of fine emulsion drops in a direct contact coolant at temperatures below their freezing point was studied. This work is mainly focused on the size and shape of the generated particles from phase change emulsified fats. Size of the particles is the major or key factor being considered during their formation, however, other factors that govern the particle size and shape were also observed. The operating parameters of the process were optimized in order to obtain particles of smaller size ranges in the window of current operating conditions. The crystallization of complex emulsion matrices is very difficult to control in the bulk at desired requirement. Hence, the emulsion drop to particle formation has advantage in comparison with the bulk solidification or crystallization. The main objective of this work is to achieve spherical emulsion particles in a direct contact cooling system. Parameters like: stability, characterization, viscosity, and the effect of different energy inputs were examined. Moreover, the effects of the capillary size, interfacial tension, temperature of the emulsion on the particle size were also monitored. | Javed Iqbal Zulfiqar Ali Murid Hussain Rizwan Sheikh Khaliq Majeed Asad Ullah Khan Joachim Ulrich | 2016 | Chinese Journal of Chemical Engineering2016，24，7： | 1 |
| 19 | Serum haematological andbiochemical indices of oxidative stress and their relationship with DNAdamage and homocysteine in Pakistani type II diabetic patients显示文摘 | Bukhari SA Javed S Ali M | 2015 | Pak JPharm Sci2015，28，3： | 1 |
| 20 | Maeronutrient assessment in apple growing region of Punjab显示文摘 | SIDDIQUE M SIDDIQUE M T ALI S JAVED A S | 2009 | Soil & Environ- ment2009，28，2： | 1 |
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