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| 1 | Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array显示文摘AIM:To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS:The expression of 44 angiogenesissecreted factors was measured by a novel cytokine antibody array methodology.The study evaluated vascular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-1 protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines.mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular endothelial growth factor receptor (VEGFR)-2 expression was analyzed by flow cytometry.RESULTS:Metastasis-derived CRC cell lines expressed a distinctive molecular profile as compared with those isolated from a primary tumor site.Metastatic CRC cell lines were characterized by higher expression of angiogenin-2 (Ang-2),macrophage chemoattractant proteins-3/4 (MCP-3/4),matrix metalloproteinase-1 (MMP-1),and the chemokines interferon γ inducible T cell α chemoattractant protein (I-TAC),monocyte chemoattractant protein I-309,and interleukins interleukin (IL)-2 and IL-1α,as compared to primary tumor cell lines.In contrast,primary CRC cell lines expressed higher levels of interferon γ (IFN-γ),insulin-like growth factor-1 (IGF-1),IL-6,leptin,epidermal growth factor (EGF),placental growth factor (PlGF),thrombopoietin,transforming growth factor β1 (TGF-β1) and VEGF-D,as compared with the metastatic cell lines.VEGF expression does not significantly differ according to the CRC cellular origin in normoxia.Severe hypoxia induced VEGF expression up-regulation but contrary to expectations,metastatic CRC cell lines did not respond as much as primary cell lines to the hypoxic stimulus.In CRC primary-derived cell lines,we observed a twofold increase in VEGF expression between normoxia and hypoxia as compared to metastatic cell lines.CRC cell lines express a similar pattern of VEGF isoforms (VEGF 121,VEGF 165 and VEGF 189) despite variability in VEGF expression,where the major transcript was VEGF 121.No relevant expression of VEGFR-2 was found in CRC cell lines,as compared to that of human umbilical vein endothelial cells and sVEGFR-1 expression did not depend on the CRC cellular origin.CONCLUSION:A distinct angiogenesis-related expression pattern characterizes metastatic CRC cell lines.Factors other than VEGF appear as prognostic markers and intervention targets in the metastatic CRC setting. | Ana Abajo Nerea Bitarte Ruth Zarate Valentina Boni Ines Lopez Marisol Gonzalez-Huarriz Javier Rodriguez Eva Bandres Jesus Garcia-Foncillas | 2012 | World Journal of Gastroenterology2012，18，7： | 8 |
| 2 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 3 | Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies显示文摘通过精子竞争的 Postcopulatory 性选择可以是影响许多繁殖特点的重要进化力量,包括精子 morphometrics。象污染物质,杀虫剂,和气候变化那样的环境因素可以影响不同精子特点,并且这样复制,在里面敏感的鸟种类。在帮助繁殖技术使用的许多处理精子的过程可以也影响精子房间的尺寸。精子房间结构(特别头) 的精确地测量的尺寸能因此被用作环境影响的指示物,在改进我们繁殖、进化的策略的理解,并且为优化帮助了繁殖技术(例如,精子 cryopreservation ) 为有鸟的使用。帮助计算机的精子 morphometry 分析(CASA-Morph ) 为估计精子 morphometry 提供一个精确、可靠的方法,减少与人的视觉评价联系的主观的问题。计算机化的系统从不同哺乳动物的种类与精液为使用被标准化了。然而,鸟的精子是丝状的,限制他们有如此的系统的分析,它被开发检查哺乳动物的精子房间的近似球形的负责人。帮助克服这,染色技术在估计计算机的轻显微镜的方法被过去常的标准化是优先级。现在的评论讨论这些点并且描述几野生、国内的鸟种的精子 morphometric 特征。 | Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo Adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez Antonio Lopez-Sebastian Agustin Lopez Goya Javier Gimeno Martinez | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 4 | Mathematical Morphology Applied to Raster Generalization of Urban City Block Maps 显示文摘 | Manuel Antonio Urena Camara Francisco Javier Ariza Lopez | 2000 | Cartographica2000，37，1： | 1 |
| 5 | Smart control of operational threats in control substations显示文摘 | Javier Lopez Cristina Alcaraz Rodrigo Roman | 2013 | Computers & Security2013，，： | 1 |
| 6 | A methodology for evaluating environmental impacts of railway freight transportation policies显示文摘 | Lgnacio Lopez Javier Rodriguez Jose Manuel Burdn | 2009 | Energy Policy2009，37，1： | 1 |
| 7 | Technology Shocks and Monetary Policy:Assessing the Fed's Performance显示文摘 | Gali J Lopez D S Javier V | 2004 | Journal of Monetary Economics2004，50，： | 1 |
| 8 | Magnetic Resonance Cholangiopancreatography Accurately Detects Common Bile Duct Stones in Resolving Gallstone Pancreatitis显示文摘 | Ali H. Hallal Jose D. Amortegui Igor M. Jeroukhimov Javier Casillas Carl I. Schulman Ronald J. Manning Fahim A. Habib Peter P. Lopez Stephen M. Cohn Danny Sleeman | 2005 | Journal of the American College of Surgeons2005，，6： | 1 |
| 9 | Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets显示文摘 | Kate A. Markey Motoko Koyama Rachel D. Kuns Katie E. Lineburg Yana A. Wilson Stuart D. Olver Neil C. Raffelt Alistair L. J. Don Antiopi Varelias Renee J. Robb Melody Cheong Christian R. Engwerda Raymond J. Steptoe Hayley S. Ramshaw Angel F. Lopez Javier V | 2012 | Blood2012，，24： | 1 |
| 10 | Securing the internet of Things显示文摘 | Rodrigo Roman Pablo Najera Javier Lopez | | 0，，09： | 1 |
| 11 | Trust management systems for wireless sensor networks: Best prac rices 显示文摘 | Javier Lopez Rodrigo Roman Isaac Agudo | 2010 | Computer Communications2010，33，9： | 1 |
| 12 | DcR1 expression in endometrial carcinomas显示文摘 | Jordi Tarragona Nuria Llecha Maria Santacana Susana Lopez Sonia Gatius David Llobet Xavier Dolcet Victor Palomar-Asenjo Francisco Javier Gonzalez-Tallada Xavier Matias-Guiu | 2010 | Virchows Archiv2010，，1： | 1 |
| 13 | Xylanase production by a new lakalitolerant isolate of Bacillus 显示文摘 | Lopez C Blanco A Javier pastor F I | 1998 | Biotechnology Letter1998，20，3： | 1 |
| 14 | Update on the treatment of metastatic renal cell carcinoma显示文摘Metastatic renal cell cancer(mRCC)management has undergone a paradigm shift in recent decades.The first revolution came with the emergence of vascular endothelial growth factor inhibitors;there was a second wave with the unprecedented success of checkpoint inhibitors,and then the latest approach,which is becoming the new care standard in mRCC,of combining these two strategies in different ways.Updated results of Checkmate-214 after 42 mo of follow-up were consistent with previously published results showing the superiority of nivolumab/ipilimumab over sunitinib in progression free survival(PFS),overall survival(OS),and objective response rate(ORR)in intermediate and high-risk patients.However,several studies presented at the American Society of Clinical Oncology 2020 suggested that the best place,and so far,the only one for nivolumab/ipilimumab is the frontline setting.The update on Keynote-426 after 23 mo of follow-up showed no superiority of pembrolizumab/axitinib over sunitinib in favorable-risk mRCC,suggesting that it should no longer be the first line of choice in low-risk patients.Finally,the phase III Checkmate 9ER trial results revealed the superiority of nivolumab/cabozantinib vs sunitinib in PFS,OS,and ORR,providing a new first-line option among all International Metastatic RCC Database Consortium risk patients.Some phase II clinical trials also presented this year showed promising results with new combination therapies such as nivolumab/sitravatinib,cabozantinib/atezolizumab,and lenvatinib/pembrolizumab,providing promising grounds upon which to start phase III studies.In addition,other works are using novel therapeutic agents with different mechanisms of action,including telaglenastat(a glutaminase inhibitor),entinostat[an inhibitor of histone deacetylases(HDACs)],and olaparib and talazoparib,poly(ADP-ribose)polymerase inhibitors widely used in other tumors.However,some questions regarding mRCC management still need to be addressed,such as head-to-head comparisons between the current options,treatment sequencing,non-clear cell mRCC,and the role of biomarkers to ascertain the best treatment choice. | Rafael Antonio Medina Lopez Ines Rivero Belenchon Javier Mazuecos-Quiros Carmen Belen Congregado-Ruiz Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，1： | 1 |
| 15 | lntegrating PMI services in CORBA applica- tions显示文摘 | Javier Lopez | 2003 | Computer Standards & Interfaces2003，，： | 1 |
| 16 | Minimum Spouting Velocity of Conical Spouted Beds Equipped with Draft Tubes of Different Configuration显示文摘 | Haritz hltzibar Gartzen Lopez Javier Bilbao | 2013 | American Chemical Society2013，52，： | 1 |
| 17 | Evaluation the european added value of TEN-T projects: a methodological proposal based on spatial spillovers, accessibil- ity and GIS 显示文摘 | Gutierrez Javier Ana conde-melhorado Elena Lopez | 2011 | Journal of Transport Geography2011，19，： | 1 |
| 18 | Soluble Angiogenic Factors in Patients With Acute Pancreatitis显示文摘 | Laura Espinosa Pablo M. Linares Alicia Bejerano Cristina Lopez Argeme Sanchez Ricardo Moreno-Otero Javier P. Gisbert | 2011 | Journal of Clinical Gastroenterology2011，，7： | 1 |
| 19 | Resistance of olive cuhivars to the defoliating pathotype of Verticillium dahliae 显示文摘 | MARTOS - MORENO Consuelo LOPEZ - ESCUDERO Francisco Javier | 2006 | HortScience2006，41，： | 1 |
| 20 | Ecotoxicological screening of reclaimed disinfected wastewater by Vibrio fischeri bioassay after a chlorination - dechlorination process显示文摘 | Javier Bayo JoseM Angosto M Dolores Gomez - Lopez | 2009 | Journal of Hazardous Materials2009，172，1： | 1 |
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