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| 1 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 2 | Analysis of the postoperative hemostatic profile of colorectal cancer patients subjected to liver metastasis resection surgery显示文摘BACKGROUND Liver resection surgery has advanced greatly in recent years,and the adoption of fasttrack programs has yielded good results.Combination anesthesia (general anesthesia associated to epidural analgesia) is an anesthetic-analgesic strategy commonly used for the perioperative management of patients undergoing surgery of this kind,though there is controversy regarding the coagulation alterations it may cause and which can favor the development of spinal hematomas.AIM To study the postoperative course of liver resection surgery,an analysis was made of the outcomes of liver resection surgery due to colorectal cancer metastases in our centre in terms of morbiditymortality and hospital stay according to the anesthetic technique used (general vs combination anesthesia).METHODS A prospective study was made of 61 colorectal cancer patients undergoing surgery due to liver metastases under general and combination anesthesia between January 2014 and October 2015.The patient characteristics,intraoperative variables,postoperative complications,evolution of hemostatic parameters,and stay in intensive care and in hospital were analyzed.RESULTS A total of 61 patients were included in two homogeneous groups: general anesthesia (n = 30) and combination anesthesia (general anesthesia associated to epidural analgesia)(n = 31).All patients had normal coagulation values before surgery.The international normalized ratio (INR) in both the general and combination anesthesia groups reached maximum values at 2448 h (mean 1.37 and 1.45 vs 1.39 and 1.41,respectively),followed by a gradual decrease.There was less intraoperative bleeding in the combination anesthesia group (769 mL) than in the general anesthesia group (1200 mL)(P < 0.05).Of the 61 patients,38.8% in the general anesthesia group experienced some respiratory complication vs 6.6% in the combination anesthesia group (P < 0.001).The time to gastrointestinal tolerance was significantly correlated to the type of anesthesia,though not so the stay in critical care or the time to hospital discharge.CONCLUSION Epidural analgesia in liver resection surgery was seen to be safe,with good results in terms of pain control and respiratory complications,and with no associated increase in complications secondary to altered hemostasis. | Guillermo Perez Navarro Ana Maria Pascual Bellosta Sonia María Ortega Lucea Mario Serradilla Martín Jose Manuel Ramirez Rodriguez Javier Martinez Ubieto | 2019 | World Journal of Clinical Cases2019，7，17： | 4 |
| 3 | Evidence for theformation of gas-phase inclusion complexes with cyclodextrins and amino acids显示文摘 | Javier Ramirez Seonghee Ahn Gabriela Grigorean | 2000 | J Am Chem Soc2000，122，： | 1 |
| 4 | Power Systems Decentralized Optimization显示文摘 | Ramirez Juan M Javier C G | 2014 | International Journal of Emerging Electric Power Systems2014，15，6： | 1 |
| 5 | A mass spectrometry method for the determination of Enantiomeric Excess in Mixtures of D, L-Amino Acids 显示文摘 | Gabriela Grigorean Javier Ramirez Seong He Ahn | 2000 | Anal Chem2000，72，： | 1 |
| 6 | Local Full-Thickness Excision as First Line Treatment for Sessile Rectal Adenomas: Long-Term Results显示文摘 | Jose M. Ramirez Vicente Aguilella Jose A. Gracia Javier Ortego Pilar Escudero Javier Valencia Ricardo Esco Mariano Martinez | 2009 | Annals of Surgery2009，，2： | 1 |
| 7 | Decoupling mesoporosity formation and acidity modifica- tion in ZSM - 5 zeolites by sequential desilication - dealu- mination 显示文摘 | Johan C Groen Jacob A Moulijn Javier P6rez -Ramirez | 2005 | Microporous and Mesoporous Materials2005，87，： | 1 |
| 8 | Hierarchicalzeolites: enhanced utilisation of microporous crystals in catalysis by advances in materialsdesign 显示文摘 | Perez - Ramirez Javier Christensen Claus H Groen Johan C | 2008 | Chemical Society Reviews2008，37，25： | 1 |
| 9 | A new kullback-leibler VAD for speech recognition in noise显示文摘 | Javier Ramirez Jose C Segura Carmen Benitez | 2004 | IEEE Signal Processing Letters2004，11，2： | 1 |
| 10 | Tandem Mass Spectrometry of Intact Proteins for Characterization of Biomarkers From Bacillus Cereus T Spores 显示文摘 | Demirev Plamen A Ramirez Javier Fenselau Catherine | 2001 | Anal Chem2001，73，57： | 1 |
| 11 | Deactivation and regeneration of iron- containing MFI zeolites in propane oxidative dehydrogenation by N2O显示文摘 | Sanchez- Galofre Olga Yolanda Segura Perez- Ramirez Javier | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 12 | Struc- tural promotion and stabilizing effect of Mg in the catalytic decomposi- tion of nitrous oxide over calcined hydrotalcite - like compounds 显示文摘 | Javier Perez - Ramirez Joost Over eijinder Freek Kapteijn | 1999 | Applied Catalysis B Environmental1999，23，1： | 1 |
| 13 | 热带安第斯山脉20世纪后期几十年的冰川演变:玻利维亚的查卡尔塔亚冰川和厄瓜多尔的安蒂扎纳冰川显示文摘自1991年起对玻利维亚的查卡尔塔亚冰川(16°S,雷亚尔山)和1995年起对厄瓜多尔的安蒂扎纳15号冰川(0°,厄瓜多尔)的质量平衡作了连续监测。在冰川消融区,按一个月尺度测量了质量平衡,提供了有关两种不同热带环境中季节性变化模式的有意义的详细数据。这两个地区最近40年来都有关于冰后退的断断续续的报道。这些资料指出,这10年来冰川退缩明显加速了;消融速率已比前几十年高3~4倍。以前在秘鲁北部测量3条冰川的变动,使我们可以假定:安第斯山脉热带山段冰川退却的速率在20世纪70年代增高了。小规模冰川(<1km)的现状特别令人担忧,象查卡尔塔亚等许多冰川将在今后10年内消失。已经收集的资料证明,在ENSO(厄尔尼诺南方涛动)变暖期消融作用显著增强,而在变冷期(拉尼娜)减弱。自20世纪70年代晚期以来,变暖事件变得更频繁、更强烈了。可以假定,它们已对安第斯山脉中部现代冰川退缩起了显著作用,还有全球气候变暖的影响。 | Bernard Francou Edson Ramirez BolivarCáceres Javier Mendoza 沈萍 | 2000 | AMBIO-人类环境杂志2000，29，7： | 0 |
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