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| 1 | Screening of flavonoid 'quercetin' from the rhizome of Smilax china Linn.for anti-psoriatic activity显示文摘Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract(100 and 200 mg/kg b.w.) and isolated flavonoid quercetin(25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results:The isolated flavonoid quercetin from the rhizome of S.china produced significant orthokeratosis(P<0.01) in the mouse tail test.In epidermal thickness,a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract(200 mg/kg) and isolated flavonoid quercetin(50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition(P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin(IC_(50),62.42± 10.20 μg/mL).Conclusions:From the above data,the flavonoid quercetin shows significant orthokeratosis,anti-inflammatory and maximum antiproliferant activities.To our knowledge,this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity. | Vijayalakshmi A Ravichandiran V Malarkodi Velraj Nirmala S Jayakumari S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 7 |
| 2 | Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir显示文摘Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events. | A Vijayalakshmi V Ravichandiran Malarkodi Velraj S Hemalatha G Sudharani S Jayakumari | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 6 |
| 3 | Synthesis and characterization of cyanate epoxy composites 显示文摘 | Jayakumari L S Thulasiraman V Sarojadevi M | 2007 | High Performance Polymers2007，19，： | 1 |
| 4 | Synthesis and characterization of cyanate epoxy composites 显示文摘 | Jayakumari L S Thulasiraman V Sarojadevi M | 2007 | High Performance Polymers2007，，19： | 1 |
| 5 | Interference Analysis of Par- tial Response Coded OFDM Signals显示文摘 | JAYAKUMARI J SAKUNTALA S P | 2008 | Journal of Engineering and Applied Sciences2008，3，4： | 1 |
| 6 | Synthesis and characterization of cyanate epoxy com- posites 显示文摘 | Jayakumari L S Thulasiraman V Sarojadevi M | 2007 | High Performance Polymers2007，，19： | 1 |
| 7 | Immobilization of papain on crosslinked polymer supports: Role of the macromolectlar matrix on enzymic activity显示文摘 | V N Rajasekharan Pillai | 1991 | J Appl Polym Sci1991，42，： | 1 |
| 8 | An intelligent approach to detect hard and soft exudates using echo state neural network 显示文摘 | Jayakumari C Santhanam T | 2008 | Information Technology2008，7，2： | 1 |
| 9 | Synthesis and characterization of cyanate epoxy composites 显示文摘 | L S Jayakumari V Thulasiraman M Sarojadevi | 2007 | High Performance Polymers2007，，19： | 1 |
| 10 | Mod- eling and validation of polyurethane based passive un- derwater acoustic absorber 显示文摘 | Jayakumari V G Shamsudeen R K Ramesh R | 2011 | Acoust Soc Am2011，30，2： | 1 |
| 11 | Modeling and validation of polyurethane based passive underwater acoustic absorber显示文摘 | Jayakumari V G Shamsudeen R K Ramesh R | 2011 | Journal of the Acoustical Society of America2011，130，2： | 1 |
| 12 | Synthesis and characterization of cyanate epoxy composites显示文摘 | Jayakumari L.S Thulasiraman V Sarojadevi M | | 0，，19： | 1 |
| 13 | A Comparative Evaluation of a Novel Flame Retardant, 3- (Tetrabromopentadecyl)-2,4,6-tribromophenol (TBPTP) with Decabromodiphenyloxide (DBDPO)for Applications in LDPE-and EVA-based Cable Materials显示文摘 | PILLAI C K S PRASAD V S MENON A R R SUDHA J D JAYAKUMARI V G KUMAR B M PAVITHRAN C TIKKU V K PRADHAN N K | 1997 | Journal of Applied Polymer Science1997，66，： | 1 |
| 14 | Modeling and validation of polyurethane based passive underwater a- coustic ahsorber显示文摘 | Jayakumari V G Shamsudeen R K Ramesh R | 2011 | Acoust Soc Am2011，30，2： | 1 |
| 15 | Effect of the properties of na- tural resin binder in a high friction composite material 显示文摘 | Bernard S S Jayakumari L S | 2014 | Polimeros2014，24，2： | 1 |
| 16 | Detection of hard exudates in color fundus images of the human retina 显示文摘 | Jayakumari C Maruthi R | 2012 | Procedia Engineering2012，，30： | 1 |
| 17 | Interference Analysis of Partial Re-sponse Coded OFDM Signals显示文摘 | JAYAKUMARI J PILLAI S S | 2008 | Journal of Engineering and Ap-plied Sciences2008，3，4： | 1 |
| 18 | Enhance lipid peroxidation in patients during coronary artery by pass grafting显示文摘 | Jayakumari N Amikalumari V | 1993 | Indian Heart J1993，45，2： | 1 |
| 19 | Oxidative stress is increased in women with epilepsy:is it a potential mechanism of anti-epileptic drug-induced teratogenesis?显示文摘 | Deepa D Jayakumari N Thomas S V | 2012 | Ann Indian Acad Neurol2012，15，4： | 1 |
| 20 | Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes-macrophages by enhanced production of ROS,TNF-a,MMP-9,and MMP-2显示文摘 | Soumyarani VS Jayakumari N | 2012 | Mol Cell Biochem2012，366，12： | 1 |
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