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2篇 您的检索式：作者名="Je Sun Lim"

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		题名	作者	年代	出处	被引量
	1	Isolation and characterization of two β-tubulin cDNA clones from rice显示文摘	Mee Sun Kang Young Ju Choi Min Chul Kim Chae Oh Lim Inhwan Hwang Moo Je Cho	1994	Plant Molecular Biology1994，，6：	1
	2	Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation显示文摘The programmed cell death ligand 1(PD-L1)and its receptor programmed cell death 1(PD-1)deliver inhibitory signals to regulate immunological tolerance during immune-mediated diseases.However,the role of PD-1 signaling and its blockade effect on human dental pulp stem cells(h DPSCs)differentiation into the osteo-/odontogenic lineage remain unknown.We show here that PD-L1 expression,but not PD-1,is downregulated during osteo-/odontogenic differentiation of h DPSCs.Importantly,PD-L1/PD-1 signaling has been shown to negatively regulate the osteo-/odontogenic differentiation of h DPSCs.Mechanistically,depletion of either PD-L1 or PD-1 expression increased ERK and AKT phosphorylation levels through the upregulation of Ras enzyme activity,which plays a pivotal role during h DPSCs osteo-/odontogenic differentiation.Treatment with nivolumab(a human anti-PD-1 monoclonal antibody),which targets PD-1 to prevent PD-L1 binding,successfully enhanced osteo-/odontogenic differentiation of h DPSCs through enhanced Ras activity-mediated phosphorylation of ERK and AKT.Our findings underscore that downregulation of PD-L1 expression accompanies during osteo-/odontogenic differentiation,and h DPSCs-intrinsic PD-1 signaling inhibits osteo-/odontogenic differentiation.These findings provide a significant basis that PD-1 blockade could be effective immunotherapeutic strategies in h DPSCs-mediated dental pulp regeneration.	So Mi Jeon Je Sun Lim Su Hwan Park Hyung Joon Kim Hyung-Ryong Kim Jong-Ho Lee	2022	International Journal of Oral Science2022，14，2：	0

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