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| 1 | NG2 Cell Response in the CNP-EGFP Mouse After Contusive Spinal Cord Injury显示文摘成年动物中枢神经系统中的NG2细胞具有异质性。脊髓损伤(SCI)后,具有少突胶质前体细胞(OPCs)功能的NG2细胞亚型如何产生反应性变化及对其正常的发育过程有何影响目前还不清楚。本文采用少突胶质细胞系细胞表达EGFP的CNP-EGFP小鼠,研究正常和SCI后的NG2细胞的特征。在正常小鼠的白质中,对EGFP+NG2+双极细胞和EGFPnegNG2+多极细胞进行鉴别。SCI后,白质损伤边缘区中的EGFP+NG2+细胞3 d增殖达高峰,损伤中心区的EGFPnegNG2+细胞增殖在损伤后7 d达高峰。损伤后EGFP+NG2+细胞的Olig2、Sox10、Sox17等转录因子、基本的膜电生理参数以及钾电流表型均与发育过程增殖的OPCs一致。EGFPnegNG2+细胞不表达少突胶质发生中的转录因子。EGFP+CC1+少突胶质细胞6周时包含在EGFP+NG2+细胞增殖峰时表达BrdU的细胞。EGFPnegCC1+少突胶质细胞未被观察到。神经胶质生长因子2和成纤维细胞生长因子2处理促进少突胶质发生,提高EGFPnegNG2+细胞数量。因此,通过EGFP和转录因子表达,时空增殖类型及对生长因子的反应,两种类型的NG2+细胞对SCI刺激发生反应。SCI后EGFP+NG2+细胞经受细胞和生理变化特征,与在早期出生后的少突胶质发生过程中NG2+细胞中的变化类似。 | JUDITH M LYTLE RAMESH CHITTAJALLU JEAN R WRATHALL VITTORIO GALLO | 2009 | 神经损伤与功能重建2009，4，1： | 7 |
| 2 | Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture显示文摘 | Ariane M Sylvie B Jean R | 1995 | Hepatology1995，21，4： | 1 |
| 3 | Occupational exposure to blood:Search for a relation between personality and behavior显示文摘 | Christian R Agnes Z Jean M M et a1 | 2000 | Infec Control and Hos Epidemi2000，21，9： | 1 |
| 4 | Surviving sepsis campaign guidelines for management of severe sepsis and septic shock显示文摘 | R Phillp Dellinger Jean M Carlet Henry Masur | 2004 | Int Care Med2004，30，4： | 1 |
| 5 | The association between IGF-Ⅰ and bone mineraldensity in women and men: the Framingham heart study显示文摘 | Jean I A Clifford J R Visser M | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 6 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 7 | Polyurethane acrylate/epoxy-amine acrylate hybrid polymer networks显示文摘 | Jean M R | | 0，，： | 1 |
| 8 | Production, oxidation and consumption of methane by soils: A review显示文摘 | Jean L M Pierre R | 2001 | Eur JSoil Biol2001，37，： | 1 |
| 9 | Effects of culture media and inhibitors on biology of'porcine early em- bryonic development in vitro 显示文摘 | Wang H F Nelida R O Jean M F | 2009 | Livestock Science2009，，： | 1 |
| 10 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 11 | Biofiltration of a mixture of volatile organic emissions显示文摘 | Aitor A Luc M Jean C R | 2001 | Air Waste Manag Assoc2001，51，12： | 1 |
| 12 | Influence of negative leader propagation on the triggering and guiding of high voltage discharges by laser filaments显示文摘 | Ackermann R Méchain G Méjean G | 2006 | Applied Physics B2006，，82： | 1 |
| 13 | Low-Fire Processing and Proper- ties of Ferrite + Dielectric Ceramic Composite 显示文摘 | Peng T M Hsu R T Jean J H | 2006 | J Am Ceram Soc2006，89，9： | 1 |
| 14 | Electricalpmperties of low-fire ferroelectric + ferrimagnetic ceramic composite显示文摘 | R T Hsu T M Peng J H Jean | 2006 | Japanese Journal of Applied Physics2006，45，： | 1 |
| 15 | A longitudinal study of relational and physical aggression in preschool 显示文摘 | Crick N R Jamie M Ostrov Jean E | 2006 | Applied Developmental Psychology2006，27，： | 1 |
| 16 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 17 | A Mixed Model Estimation ofAge, Period, and Cohort Effects显示文摘 | 0’Brien R M Kenneth H Jean S | 2008 | Sociological Methods & Re-search2008，，36： | 1 |
| 18 | Health life expectancy: evaluation of global indicator of change in population health显示文摘 | Jean M R Karen R | 1991 | BMJ1991，302，4： | 1 |
| 19 | Ontology matching with semantic verification 显示文摘 | Jean Y R Shironoshita E P Kabuka M R | 2009 | Web Semantics: Science Ser- vices and Agents on the World Wide Web2009，7，3： | 1 |
| 20 | A comparison of forecast performance between Federal Reserve staff forecasts, simple reduced-form models, and a DSGE model显示文摘 | Edge R M Michael T K Jean P L | 2010 | Journal of Applied Econometrics2010，25，2： | 1 |
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