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| 1 | 手术后患者疼痛控制满意度状况及影响因素的研究显示文摘目的描述手术后患者对疼痛控制的满意度状况,探讨影响疼痛控制满意度的因素。方法采用多阶段抽样方法,随机抽取北京地区5家综合性三级甲等医院,对符合入选标准的304例手术后第2天的住院疼痛患者进行了调查,问卷由休斯顿疼痛情况调查表、疼痛治疗指数和病历资料核查表3个部分组成。结果术后患者对疼痛控制总体满意度平均评分为7.3。疼痛控制教育、医生对疼痛的处理、疼痛减轻、患者受到的所有针对疼痛的照料、医生或护士是否告诉患者要优先有效地控制疼痛以及手术次数共6个因素进入回归方程,是影响疼痛控制满意度的主要因素。结论患者对术后疼痛控制较为满意;疼痛控制服务因素是影响手术后患者疼痛控制满意度的主要因素。建议制订术后疼痛控制制度和标准,采取针对性措施,改善术后疼痛控制质量,提高术后患者对疼痛控制的满意度。 | 沈曲 李峥 Gwen Sherwood Jeanette A.McNeill | 2007 | 中华护理杂志2007，42，3： | 142 |
| 2 | 东海原甲藻修订及与相关原甲藻的分类学比较显示文摘分析了东海原甲藻 (ProrocentrumdonghaienseLu)显微结构 ,并与具齿原甲藻 (Prorocentrumden tatumStein)模式种和Schiller的钝头原甲藻的描述等进行了比较 ,结果表明 ,它们之间的形态结构和个体大小具有很大的差别 ,这些差异远超出了同种个体因环境不同所造成的形态变化范围 .从细胞形态及其表面结构可以判断 ,日本、韩国海区所记录并报道的“P .dentatum”与我国东海的东海原甲藻应属同一种 .因此可以认为 ,我国东海赤潮高发区以及在韩国、日本海区的出现的高生物量 (highbiomassbloom formingspecies)赤潮原甲藻不是Stein所发表的具齿原甲藻 ,而是东海原甲藻 ,并对其进行了进一步修订 ,其种名应为东海原甲藻ProrocentrumdonghaienseLu . | 陆斗定 齐雨藻 Jeanette Goebel 邹景忠 高亚辉 | 2003 | 应用生态学报2003，14，7： | 55 |
| 3 | FIVE RED TIDE SPECIES IN GENUS PROROCENTRUM INCLUDING THE DESCRIPTION OF PROROCENTRUM DONGHAIENSE LU SP. NOV.FROM THE EAST CHINA SEA显示文摘A new planktonic dinoflagellate, Prorocentrum donghaiense Lu sp. nov., is described in the present paper. The water sample was collected from the Changjiang Estuary, the East China Sea. The species identification is based on shape, size, surface micro morphology, ornamentation of thecal plates and the architecture of the periflagellar area and the intercalary bands as seen by light and scanning electron microscope. Prorocentrum donghaiense Lu sp. nov. is compared with other prorocentrum species with respect to morphological characteristics and bloom behavior. It is not known whether Prorocentrum donghaiense Lu sp. nov produces phycotoxins like some other Prorocentrum species. Four other red tide species in the family Prorocentraceae (Dinophyceae), namely P. balticum , P. minimum, P. micans, P. triestinum , were examined and identified by light and scanning electron microscope. They have been recorded as bloom forming species. Some aggregates of Prorocentrum are observed at the end of blooms. An event of strong discoloration caused by P. donghaiense could be detected by satellite sensor in the East China Sea in the late spring of 1995. | 陆斗定 Jeanette Goebel | 2001 | Chinese Journal of Oceanology and Limnology2001，19，4： | 46 |
| 4 | Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients显示文摘AIM:To assess the appropriateness of the indication and route of administration of proton-pump-inhibitors (PPIs) and their associated cost impact. METHODS:Data collection was performed prospec-tively during a 6-mo period on 340 patients who re-ceived omeprazole intravenously during their hospital stay in non-intensive care floors. Updated guidelines were used to assess the appropriateness of the indication and route of administration. RESULTS:Complete data collection was available for 286 patients which were used to assess intravenous (IV) PPIs utilization. Around 88% of patients were receiving PPIs for claimed stress ulcer prophylaxis (SUP) indication; of which,only 17% met the guideline criteria for SUP indication,14% met the criteria for non-steroidal-anti-inflammatory drugs-induced ulcer prophylaxis,while the remaining 69% were identifi ed as having an unjustified indication for PPI use. Theinitiation of IV PPIs was appropriate in 55% of pa-tients. Half of these patients were candidates for switching to the oral dosage form during their hos-pitalization,while only 36.7% of these patients were actually switched. The inappropriate initiation of PPIs via the IV route was more likely to take place on the medical floor than the surgical floor (53% vs 36%,P = 0.003). The cost analysis associated with the appro-priateness of the indication for PPI use as well as the route of administration of PPI revealed a possible saving of up to $17 732.5 and $14 571,respectively. CONCLUSION:This study highlights the over-utili-zation of IV PPIs in non-intensive care unit patients. Restriction of IV PPI use for justified indications and route of administration is recommended. | Soumana C Nasser Jeanette G Nassif Hani I Dimassi | 2010 | World Journal of Gastroenterology2010，16，8： | 23 |
| 5 | Mannhei mia granulo matis PCR检测方法的建立显示文摘Mannheimia granulomatis是导致牛、羊呼吸道传染病的一种病原菌。为快速、准确诊断由该菌导致的疫病,从基因库中获得M.granulomatis的基因序列,再从M.granulomatis的基因序列中获得与其他细菌包括溶血性曼氏杆菌和多杀性巴氏杆菌等不同的基因片段,设计引物,建立了特异性好、敏感性较高的M.granulomatis的PCR诊断方法。结果表明,其特异性为100%,最小检出量为5×104cfu/mL^5×103cfu/mLM.granulomatis或1/10个单个菌落。 | 安烨 龚玉梅 Jeanette Miflin Pat Blackall 孙惠玲 张培君 | 2007 | 动物医学进展2007，28，5： | 8 |
| 6 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 7 | 定量分析加热后乳清蛋白与酪蛋白的结合显示文摘将复原脱脂乳在 70~ 90℃范围内加热 1 0~ 2 5min后 ,用超速离心分离出酪蛋白微粒 ,并用毛细管电泳法定量分析。结果显示 ,β-乳球蛋白更容易结合到酪蛋白微粒上。当加热条件为 70℃、1 0 min时就有相当多的 β-乳球蛋白发生了这种结合 ,这时酪蛋白微粒中没发现任何 α-乳清蛋白 ,只有当加热温度大于 75℃时才有少量 α-乳清蛋白与酪蛋白微粒结合。复原脱脂乳经 90℃、2 5min加热后几乎所有 β-乳球蛋白都已转入酪蛋白微粒部分 ,而只有近 50 %的α-乳清蛋白转入酪蛋白微粒。 | 周志伟 盛东生 许永红 Merete Faergem Jeanette Otte Karsten Bruun Qvist | 2000 | 食品工业科技2000，21，5： | 7 |
| 8 | 神经内科护理工作量测量指标及其内涵研究显示文摘目的建立具有神经内科特色的护理工作量测量指标,并对指标进行系统性描述。方法通过现场观察、专家会议与专家咨询,建立神经内科护理工作量测量指标。结果确定了护理工作量测量指标64项,其中神经内科专科护理工作量测量指标15项;以患者为中心,规范化系统性描述了各测量指标。结论护理工作量测量指标的构建是开展护理工作量研究的基础,可为人力资源配置及绩效管理提供依据。 | 陈红 蒋红 顾妙娟 赵琦 任学芳 黄莺 王屹骏 Jeanette Ives Erickson 马昕 夏云 黄虹 林建华 | 2014 | 护理学杂志(综合版)2014，29，5： | 6 |
| 9 | 溶血性曼氏杆菌PCR检测方法的研究显示文摘溶血性曼氏杆菌是导致牛、羊呼吸道传染病的一种病原菌。为快速、准确诊断由本菌导致的疾病 ,从基因库中获得溶血性曼氏杆菌( M.haemolytica )的基因序列 ,再从其基因序列中获得与其它细菌包括 M.annheimiagranulomatis,M.varigena ,M.ruminalis,M.glucosidal ,M.annheimiaspp和多杀性巴氏杆菌等不同的基因片段 ,设计成引物 ,建立了特异性好、敏感性高的 M.haemolytica PCR检测方法。结果表明 ,除溶血性曼氏杆菌为阳性外 ,其余所有细菌均为阴性 ,特异性为 1 0 0 % ,最小检出量为 8× 1 0 2 cfu/ m L 曼氏杆菌或 1 / 1 0个单个菌落。检验人工感染牛 ,检出率为 75%。此PCR检测方法的建立 ,为 M. | 张培君 Jeanette Miflin Pat Blackall 陈卓明 孙惠玲 龚玉梅 苗得园 | 2003 | 动物医学进展2003，24，4： | 6 |
| 10 | Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans显示文摘Little is known about the inheritance of very low heteroplasmy mitochondria DNA(mtDNA)variations.Even with the development of new next-generation sequencing methods,the practical lower limit of measured heteroplasmy is still about 1%due to the inherent noise level of the sequencing.In this study,we sequenced the mitochondrial genome of 44 individuals using Illumina high-throughput sequencing technology and obtained high-coverage mitochondria sequencing data.Our study population contains many mothere offspring pairs.This unique study design allows us to bypass the usual heteroplasmy limitation by analyzing the correlation of mutation levels at each position in the mtDNA sequence between maternally related pairs and non-related pairs.The study showed that very low heteroplasmy variants,down to almost 0.1%,are inherited maternally and that this inheritance begins to decrease at about 0.5%,corresponding to a bottleneck of about 200 mtDNA. | Yan Guo Chung-I Li Quanhu Sheng Jeanette F.Winther Qiuyin Cai John D.Boice Yu Shyr | 2013 | Journal of Genetics and Genomics2013，40，12： | 4 |
| 11 | TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants显示文摘Protein abundance and localization at the plasma membrane(PM)shapes plant development and mediates adaptation to changing environmental conditions.It is regulated by ubiquitination,a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation.To understand the significance and the variety of roles played by this reversible modification,the function of ubiquitin receptors,which translate the ubiquitin signature into a cellular response,needs to be elucidated.In this study,we show that TOL(TOM1-like)proteins function in plants as multivalent ubiquitin receptors,governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport(ESCRT)pathway.TOL2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding domains.Mutation of these domains results not only in a loss of ubiquitin binding but also altered localization,abolishing TOL6 ubiquitin receptor activity.Function and localization of TOL6 is itself regulated by ubiquitination,whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes,assisting in the fine-tuning of the delicate interplay between protein recycling and downregulation.Taken together,our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants. | Jeanette Moulinier-Anzola Maximilian Schwihla Lucinda De-Araujo Christina Artner Lisa Jorg Nataliia Konstantinova Christian Luschnig Barbara Korbei | 2020 | Molecular Plant2020，13，5： | 3 |
| 12 | Morphological and genetic comparison of two strains of a Prorocentrum species isolated from Zhejiang coastal water of China and Masan Bay of Korea显示文摘In this paper, we examined the detailed morphology of two strains of Prorocentrum isolated from the coastal waters of Zhejiang (Wenling area), China, and Masan Bay of Korea. A taxonomic comparison was made among strains on the basis of morphological and molecular data. The cellular dimensions of the Chinese Wenling strain (LAMB090508) and Korean strain (PDKS0206) were similar and the cells of both strains were of asymmetric and elongated shape. The posterior end of most cells was rounded. Megacytic zones of aged cells were broader with dense tiny knobs. The roundish nucleus was located in the posterior part of the cell. A few irregular shaped chloroplasts were distributed within the cell. The nucleotide similarity of the two strains, determined from the 5.8S rDNA-ITS sequences, was 99.83%. The comparative results of morphology and molecular analysis suggest that both strains isolated from China and Korea were the identical species, Prorocentrum donghaiense Lu. | 陆斗定 王红霞 黄海燕 夏平 戴鑫烽 GBEL Jeanette JEONG Hae Jin | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 3 |
| 13 | An assessment of direct and indirect effects of climate change for populations of the Rocky Mountain Apollo butterfly ( Parnassius smintheus Doubleday)显示文摘气候变化正在发生,昆虫正在反应。为生态学家和经理的当前的挑战正在预言有机体怎么将对继续气候变化并且决定怎么减轻潜在的否定效果作出回应。与为包含种类的分发的气候变化的宽广规模预言相对照,在这篇文章,我们加亮岩石山阿波罗蝴蝶(Parnassius smintheus Doubleday ) 的本地人口在被预言对气候变化作出回应的许多方法。用在过去的 15 年收集的试验性、观察的数据,我们详细说明直接、间接的效果。另外,我们鉴别在我们限制能力预言人口怎么将对气候作出回应的知识的限制变化。一些变化例如更温暖的冬季温度,可以有有益的效果;然而,大多数气候变化的效果将是有害的。在雪盖子的可变性在 overwintering 期间,时期和产地损失由于森林侵入有最大的潜在的否定效果。 | Stephen F. Matter Amanda Doyle Kurt Illerbrun Jeanette Wheeler Jens Roland | 2011 | Insect Science2011，18，4： | 3 |
| 14 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 15 | 东海陆架黑潮区鸟尾藻的分类及其生态分布特点显示文摘对东海陆架黑潮区及邻近海域的鸟尾藻进行了分类与生态分布研究 ,共检出 5种鸟尾藻 :大鸟尾藻、斯氏鸟尾藻、美丽鸟尾藻、赛氏鸟尾藻和方鸟尾藻。扫描电镜观察结果表明 ,鸟尾藻的纵沟左边翅是由两块边翅相连接而成 ,即由右下体边翅与纵沟左边翅相连而成。鸟尾藻分布的生物边界与暖水到达的位置相吻合 ,对东海黑潮及其台湾暖水水系具有显著的指示作用。 | 陆斗定 Jeanette Gbel | 2001 | 东海海洋2001，19，3： | 3 |
| 16 | 脱脂乳的不同热处理对其酸奶凝胶流变学性质的影响显示文摘研究了复原脱脂乳经不同加热处理后其酸奶凝胶形成过程中流变学特性的变化。复原脱脂乳经 70~ 90℃处理 10~ 2 5min ,用D 葡萄糖 δ 内酯酸化成胶。用流变学方法动态监测凝胶性能 ,并监测酸化过程和成胶时间。结果显示 ,不同条件下处理后的脱脂乳在酸化过程中 ,pH值并未改变 ,但凝胶储存模量 (G′)和损失模量 (G″)随受热程度的增加而增加 ,只是当加热温度为 90℃时反而随加热时间的延长而降低。在 85℃加热 2 5min或 90℃加热后 ,脱脂乳酸性凝胶的流变学曲线呈现出异常情况 ,这时G′和G″的增长出现两个迟缓期。 | 周志伟 许永红 Merete Faergemand Jeanette Otte Karsten Bruun Qvist | 2000 | 中国乳品工业2000，28，5： | 3 |
| 17 | Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus显示文摘 | Walter J. Pories Melvin S. Swanson Kenneth G. MacDonald Stuart B. Long Patricia G. Morris Brenda M. Brown Hisham A. Barakat Richard A. deRamon Gay Israel Jeanette M. Dolezal Lynis Dohm | 1995 | Annals of Surgery1995，，3： | 2 |
| 18 | 中国东海和韩国马山湾海域2株原甲藻的形态结构和分子序列比较显示文摘对采自我国东海温岭海域和韩国南部马山湾海域的2株原甲藻进行了藻种分离、纯化培养及rDNA ITS分子序列的PCR扩增与测序,并运用显微镜、扫描电镜、Jukes-Cantor距离矩阵及构建的系统发育树,比较研究了2株原甲藻的形态结构和分子序列。结果表明:温岭藻株(LAMB090508)和马山湾藻株(PDKS0206)具有十分相近的形态结构,细胞均呈不对称梨形,大部分细胞底部呈圆卵形,老化细胞在两侧壳面连接处形成间接带,细胞核位于细胞下半部,呈圆球形,细胞内存在不规则板块状叶绿体。温岭藻株和马山湾藻株的rDNA ITS分子序列总长度均为591 bp,GC含量均为49%,相似度为99.83%,核苷酸差异值为0.002。系统发育树显示,温岭藻株、马山湾藻株和东海原甲藻Pro-rocentrum donghaiense(AY465116)聚在一起,应属同一物种,支持率为100%。综合形态结构和分子序列的比较结果表明,分布于我国东海温岭海域和韩国马山湾海域的2株原甲藻属于同一物种,且均为东海原甲藻Prorocentrum donghaiense Lu。 | 王红霞 陆斗定 黄海燕 夏平 戴鑫烽 Jeanette GOEBEL 鄭海■ | 2011 | 海洋学研究2011，29，1： | 2 |
| 19 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 20 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
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