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| 1 | From histology to micro-CT:Measuring and modeling resorption cavities and their relation to bone competence显示文摘The process of bone remodelling plays an essential role in the emergence and maintenance of bone geometry and its internal structure.Osteoclasts are one of the three main bone cell types that play a crucial role in the bone remodelling cycle.At the microstructural level,osteoclasts create bone deficits by eroding resorption cavities.Understanding how these cavities impair the mechanical quality of the bone is not only relevant in quantifying the impact of resorption cavities in healthy bone and normal aging,but maybe even more so in quantifying their role in metabolic bone diseases.Meta-bolic bone diseases and their treatment are both known to affect the bone remodelling cycle;hence,the bone mechanical competence can and will be affected.How-ever,the current knowledge of the precise dimensions of these cavities and their effect on bone competence is rather limited.This is not surprising considering the difficulties in deriving three-dimensional(3D)properties from two-dimensional(2D)histological sections.The measurement difficulties are reflected in the evalua-tion of how resorption cavities affect bone competence.Although detailed 3D models are generally being used to quantify the mechanical impact of the cavities,the representation of the cavities themselves has basicallybeen limited to simplified shapes and averaged cavityproperties.Qualitatively,these models indicate that cav-ity size and location are important,and that the effectof cavities is larger than can be expected from simplebone loss.In summary,the dimensions of osteoclastresorption cavities were until recently estimated from2D measures;hence,a careful interpretation of resorp-tion cavity dimensions is necessary.More effort needsto go into correctly quantifying resorption cavities usingmodern 3D imaging techniques like micro-computedtomography(micro-CT)and synchrotron radiation CT.Osteoclast resorption cavities affect bone competence.The structure-function relationships have been ana-lysed using computational models that,on one hand,provide rather detailed information on trabecular bonestructure,but on the other incorporate rather crudeassumptions on cavity dimensions.The use of high-resolution representations and parametric descriptionscould be potential routes to improve the quantitativefidelity of these models. | Jef Vanderoost G Harry van Lenthe | 2014 | World Journal of Radiology2014，6，9： | 3 |
| 2 | Prospective clinical ecalution ofelectronic portal imaging device 显示文摘 | Jef M M Mary V G Waller R B | 1996 | Int J Radiat Oncol Biol Phys1996，，34： | 1 |
| 3 | Discriminating between critical and nncritical disturbances in (Bio) chemical bach processes prediction Research, NAES T, using m 显示文摘 | GEERT G JEF V JAN F | 2012 | ulti-model fault detection and end-quality Industrial and Engineering Chemistry2012，51，1： | 1 |
| 4 | Discriminating between critical and noncritical disturbances in (Bio) chemical bach processes using multi-model fault detection and end-quality prediction 显示文摘 | GEERT G JEF V JAN F | 2012 | Industrial and Engineering Chemistry Research2012，51，12： | 1 |
| 5 | Pharmacology of itraconazole显示文摘 | KAREL D B JEF V G | 2001 | Drugs2001，61，1： | 1 |
| 6 | Discriminating between critical and noncritical disturbances in chemical batch process using multimode fault detection and end-quality prediction 显示文摘 | GEER G JEF V JAN F M | 2012 | Industrial and Engineering Chemistry Research2012，51，12： | 1 |
| 7 | Peroxynitrite scavenging of flavonoids: structure activity relationship显示文摘 | Chantal G M Heijnen Guido R MM Haenen Jef A J M Vekemans | 2001 | Envir Toxicol Pharmacol2001，10，： | 1 |
| 8 | Peroxynitrite scavenging of flavonoids : structure activity relationship 显示文摘 | Heijinen Chantal G M Haenen Guido R M M Vekemans Jef A J M | 2001 | Environmental Toxicology and Pharmacology2001，10，4： | 1 |
| 9 | Dynamic model-based fault diagnosis for (bio)chemical batch processes 显示文摘 | Pieter V Geert G Jef V | 2012 | Computers and Chemical Engineering2012，40，1： | 1 |
| 10 | Discriminating between critical and noncritical disturbances in (bio)chemical bach processes using 显示文摘 | Gerrt G Jef V Jan F M | 2012 | Industrial and Engineering Chemistry Research2012，51，5： | 1 |
| 11 | Pharmacology of itraconazole显示文摘 | KAREL D B JEF V G | 2001 | Drugs2001，61，1： | 1 |
| 12 | Prospective clinical evalution of electronic portal imaging device显示文摘 | Jef M M Mary V G Waller R B | 1996 | Int J Radiat Oncol Biol Phys1996，34，： | 1 |
| 13 | Discriminating between criti-cal and noncritical disturbances in ( bio) chemical bachprocesses using multi-model fault detection and end-qual-ity prediction显示文摘 | GEERT G JEF V JAN F | 2012 | Industrial and Engineering ChemistryResearch2012，51，12： | 1 |
| 14 | Pharmacology of itraconazole显示文摘 | Karel D B Jef V G | 2001 | Drugs2001，61，1： | 1 |
| 15 | Dynamic model-based fault diagnosis for (bio) chemical batch processes 显示文摘 | Pieter V K Geert G Jef V | 2012 | Computer and Chemical Engi- neering2012，40，5： | 1 |
| 16 | Discriminating between critical and noncritical disturbances in (bio) chemical batch processes using multimodel fault detection and end-quality prediction显示文摘 | Geert G Jef V Jan F M | 2012 | Industrial and Engineering Chemistry Research2012，51，12： | 1 |
| 17 | TIP,a novel host fac- tor linking eallose degradation with the cell-to-cell move- ment of Potato virus X显示文摘 | Ingela F Jef G Anthony P | 2003 | Molecular Plant-Microbe In- teractions2003，16，2： | 1 |
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