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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Incidence and characteristics of viral community-acquired pneumonia in adults显示文摘 | Jennings L C Anderson T P Beynon K A | 2008 | Thorax2008，63，1： | 1 |
| 3 | Resticted pattern of variant exon express in human papillary thyroid carcinoma显示文摘 | Jennings T Kobinson L | 1996 | Cancer Res1996，56，5： | 1 |
| 4 | An Equilibrium Model of Asset Trading with Sequential Information Arrival 显示文摘 | Jennings R H Starks L T Fellingham J C | 1981 | Journal of Finance1981，，36： | 1 |
| 5 | Cutting forces in ultrasonically assisted drilling of carbon fibre-reinforced plastics 显示文摘 | Makhdum F Jennings L T Roy A | 2012 | Journal of Physics: Conference Series2012，382，01： | 1 |
| 6 | Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle显示文摘 | Jennings L J Xu Q W Firth T A | 1999 | Am J Physiol1999，277，5： | 1 |
| 7 | Three-dimensional analysis of the screening effectiveness of hollow pile barriers for foundation-induced vertical vibration显示文摘 | TSAI P H ZHENG Y F JEN T L | 2008 | Computer Geoteehnique2008，35，： | 1 |
| 8 | Three-dimensional analysis of the screening effectiveness of hollow pile barriers for foundation-induced vertical vibration 显示文摘 | Tsai P H Feng Z Y Jen T L | 2008 | Computers and Geotechnics2008，35，3： | 1 |
| 9 | Compositional analysis of lignocellulosic materials:Evaluation of methods used for sugar analysis of waste paper and straw 显示文摘 | Foyle T Jennings L Mulcahy P | 2007 | Bioresource Technology2007，98，： | 1 |
| 10 | Restrictd patterns of CD44 variant exon espression in human papillary thyroid carcinoma显示文摘 | Jennings T Robinson L | 1996 | Cancer Res1996，56，： | 1 |
| 11 | Design, simulation, and fabrication of broadband coaxial matched loads for the frequency range from 0 to 110GHz显示文摘 | ANDREAS T JENS L GERD H | 2014 | International Journal of Microwave and Wireless Technologies2014，，： | 1 |
| 12 | A two-stage SIR bandpass filter with an ultra-wide upper rejection band显示文摘 | CHING L H JEN T K | 2007 | IEEE Microwave and Wirless Components Letters2007，，1： | 1 |
| 13 | Design of cross-coupled quarter-wave SIR filters with plural transmission zeros显示文摘 | CHING L H JEN T K | 2006 | IEEE MTT-Digest2006，，6： | 1 |
| 14 | Rapid sequence analysis in primary lung cancer using an oligouncleotide probe array 显示文摘 | Halachmi S Chow J T Wu L Halachmi N Yang S C Wehange S Jen J Sidransky D | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 15 | Dispase treated acellular dermal matrix as a dermal substitute in rats 显示文摘 | WALTER R J JENNINGS L J MATSUDA T | 1997 | Curt Surg1997，54，5： | 1 |
| 16 | Restricted pattern of CD44 variant exon expression in human papillay thyroid carcinoma 显示文摘 | Emark G Jennings T Robinson L | 1998 | Cancer Res1998，56，5： | 1 |
| 17 | Opioids for the palliation of breathlessness in terminal illness显示文摘 | JENNINGS A L DAVIES A N HIGGINS J P T | 2004 | Cochrane Database Syst Rev2004，57，1： | 1 |
| 18 | Restricted patterns of CD44 variant exon expression in human papillary thyroid carcinoma显示文摘 | Ermak G Jennings T Robinson L | 1996 | Cancer Research1996，56，5： | 1 |
| 19 | Ball bearing skidding under radial and axial loads显示文摘 | Neng T L Jen F L | 2002 | Mechanism and Machine Theory2002，37，1： | 1 |
| 20 | Travos:trust and reputation in the coutext of inaccurate information sources显示文摘 | Teacy W T L Patel J Jennings N R | 2006 | Autonomous Agents and Multi-agent Systems2006，12，2： | 1 |
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