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| 1 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 2 | A novel route for the preparation of dimeric tetraorganodistannoxanes 显示文摘 | JENS B DAINIS D VONG S K | 2002 | J Organomet Chem2002，659，： | 1 |
| 3 | Assessing forest canopies and understorey illumination:canopy closure,canopy cover and other measures显示文摘 | JENNINGS S B BROWN N D SHEIL D | 1999 | Forestry1999，72，： | 1 |
| 4 | Excess returns to R&D-intensive firms显示文摘 | Chambers D Jennings R Thompson R B I | 2002 | Review of Accounting Studies2002，7，23： | 1 |
| 5 | Ethics and Public Health:Forging a Strong Relationship 显示文摘 | Callahan D Jennings B | 2002 | Am J Pub Health2002，，92： | 1 |
| 6 | Preparation and functional assessment of composite chitosan-nanohydroxyapatite scaffolds for bone regeneration显示文摘 | Reves B T Jennings J A Bumgardner J D | 2012 | J Funct Biomater2012，3，1： | 1 |
| 7 | MR imaging of synovial sarcoma with radiologic-pathologic correlation显示文摘 | Murphey M D Gibson M S Jenning B T | 2006 | Radiologics2006，26，5： | 1 |
| 8 | Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indoloquinazoline-6,12-dione derivatives in relate to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures显示文摘 | BHATTACHARJEE A K SKANCHY D J JENNINGS B | 2002 | Bioorg Med Chem2002，10，6： | 1 |
| 9 | Policy-constrained bio-inspired processes for autonomic route management显示文摘 | Balasubramaniam S Botvich D Jennings B | 2009 | Computer Networks2009，53，10： | 1 |
| 10 | Black carbon aerosol and carbon monoxide in European regional polluted air mass at Mace Head,Ireland during 1995-1998显示文摘 | Derwent R G Ryall D B Jennings S G | 2001 | Atmospheric Environment2001，35，： | 1 |
| 11 | Strategy-Performance Relationships in Service Firms:A Test for Equifinality显示文摘 | JENNINGS D F RAJARATNAM D LAWRENCE F B | 2003 | Journal of Man- agerial2003，15，2： | 1 |
| 12 | Remote Sensing of Impervious Surfaces:A Review显示文摘 | Slonecker E T Jennings D B Garofalo D | 2001 | Remote Sensing Reviews2001，20，3： | 1 |
| 13 | Measuring Organizational Cultures: A Qualitative and Quantitative Study across Twenty Cases 显示文摘 | HOFSTEDE G NEU OHAYV D | 1990 | Admin- istrative Science Quarterly1990，35，2： | 1 |
| 14 | Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST Procedures 显示文摘 | Bhattacharjee A K Skanchy D J Jennings B | 2002 | J Bioorg Med Chem2002，10，： | 1 |
| 15 | 查看详情显示文摘 | BOAL D H GELBKE C JENNINGS B K | | 0，，： | 1 |
| 16 | Intensity interferometry in subatomic physics显示文摘 | BOAL D H GELBKE C K JENNINGS B K | 1990 | Rev Mod Phys1990，62，3： | 1 |
| 17 | Changes in anthropogenic impervious surfaces, precipitation and daily streamflow, discharge: a historical perspective in a mid Atlantic subwatershed显示文摘 | Jennings D B Jarnagin S T | 2002 | LallClscape Ecology2002，17，47： | 1 |
| 18 | Assessing Time-to-Failure Due to Conductive Filament Formation in Multi-Layer Organic Laminates显示文摘 | Rudra B Pecht M Jennings D | 1994 | IEEE Trans On CPMT-PartB1994，17，3： | 1 |
| 19 | Thompson, excess return to R&D-intensive firms显示文摘 | CHAMBERS D R JENNINGS R B | 2002 | Review of Aeeounting Studies2002，7，2： | 1 |
| 20 | Thy1+ bone marrow cells regulate the induction of murine syngeneic graft-versus-host disease显示文摘 | Bryson J S Jennings C D Caywood B E | 1993 | Transplantation1993，56，4： | 1 |
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