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| 1 | KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer显示文摘 | Stefan Boeck Andreas Jung Rüdiger P. Laubender Jens Neumann Rosalind Egg Clara Goritschan Steffen Ormanns Michael Haas Dominik P. Modest Thomas Kirchner Volker Heinemann | 2013 | Journal of Gastroenterology2013，，4： | 2 |
| 2 | Postconditioning with a CpG containing Oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model显示文摘 | Se-Chan Kim Shuijing Wu Xiangming Fang Jens Neumann Lars Eichhorn Grigorij Schleifer Olaf Boehm Rainer Meyer Stilla Frede Andreas Hoeft Georg Baumgarten Pascal Knuefermann | 2014 | Life Sciences2014，，： | 1 |
| 3 | Biomechanical analyses of prosthetic mesh repair in a hiatal hernia model显示文摘 | Patrick Hamid Alizai Sofie Schmid Jens Otto Christian Daniel Klink Anjali Roeth Jochen Nolting Ulf Peter Neumann Uwe Klinge | 2014 | J. Biomed. Mater. Res2014，，7： | 1 |
| 4 | White-coat hypertension and autonomic nervous system dysregulation 显示文摘 | Neumann SA Jennings JR Muldoon MF | 2005 | Am J Hypertens2005，18，51： | 1 |
| 5 | White-coat hypertension and autonomic nervous system dysregulation显示文摘 | Neumann S A Jennings J R Muldoon M F Manuck S B | 2005 | Am J Hypertens2005，18，： | 1 |
| 6 | White-coat hypertension and autonomic nervous system dysregulation显示文摘 | Neumann SA Jennings JR Muldoon MF | 2005 | Am J hypertens2005，18，： | 1 |
| 7 | Alterations in the EGFR pathway coincide in colorectal cancer and impact on prognosis显示文摘 | Jens Neumann Laura Wehweck Susanne Maatz Jutta Engel Thomas Kirchner Andreas Jung | 2013 | Virchows Archiv2013，，4： | 1 |
| 8 | Challenges in the Technology Development for Additive Manufacturing in Space显示文摘Instead of foreseeing and preparing for all possible scenarios of machine failures,accidents,and other challenges arising in space missions,it appears logical to take advantage of the flexibility of additive manufacturing for“in-space manufacturing”(ISM).Manned missions into space rely on complicated equipment,and their safe operation is a great challenge.Bearing in mind the absolute distance for manned missions to the Moon and Mars,the supply of spare parts for the repair and replacement of lost equipment via shipment from Earth would require too much time.With the high flexibility in design and the ability to manufacture ready-to-use components directly from a computer-aided model,additive manufacturing technologies appear to be extremely attractive in this context.Moreover,appropriate technologies are required for the manufacture of building habitats for extended stays of astronauts on the Moon and Mars,as well as material/feedstock.The capacities for sending equipment and material into space are not only very limited and costly,but also raise concerns regarding environmental issues on Earth.Accordingly,not all materials can be sent from Earth,and strategies for the use of in-situ resources,i.e.,in-situ resource utilization(ISRU),are being envisioned.For the manufacturing of both complex parts and equipment,as well as for large infrastructure,appropriate technologies for material processing in space need to be developed. | Andrea Zocca Janka Wilbig Anja Waske Jens Günster Martinus Putra Widjaja Christian Neumann Mélanie Clozel Andreas Meyer Jifeng Ding Zuoxin Zhou Xiaoyong Tian | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 1 |
| 9 | Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis显示文摘 | Jamieson Thomas Clarke Mairi Steele Colin W Samuel Michael S Neumann Jens Jung Andreas Huels David Olson Michael F Das Sudipto Nibbs Robert J B Sansom Owen J | 2012 | EN2012，，： | 1 |
| 10 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 11 | The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma显示文摘 | Andreas Jordan Regina Scholz Klaus Maier-Hauff Frank K.H. Landeghem Norbert Waldoefner Ulf Teichgraeber Jens Pinkernelle Harald Bruhn Fabian Neumann Burghard Thiesen Andreas Deimling Roland Felix | 2006 | Journal of Neuro - Oncology2006，，1： | 1 |
| 12 | The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma显示文摘 | Andreas Jordan Regina Scholz Klaus Maier-Hauff Frank K.H. Landeghem Norbert Waldoefner Ulf Teichgraeber Jens Pinkernelle Harald Bruhn Fabian Neumann Burghard Thiesen Andreas Deimling Roland Felix | 2006 | Journal of Neuro - Oncology2006，，1： | 1 |
| 13 | Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection of Helicobacter pylori显示文摘BACKGROUND Endofaster is an innovative technology that can be combined with upper gastrointestinal endoscopy(UGE)to perform gastric juice analysis and real-time detection of Helicobacter pylori(H.pylori).AIM To assess the diagnostic performance of this technology and its impact on the management of H.pylori in the real-life clinical setting.METHODS Patients undergoing routine UGE were prospectively recruited.Biopsies were taken to assess gastric histology according to the updated Sydney system and for rapid urease test(RUT).Gastric juice sampling and analysis was performed using the Endofaster,and the diagnosis of H.pylori was based on real-time ammonium measurements.Histological detection of H.pylori served as the diagnostic gold standard for comparing Endofaster-based H.pylori diagnosis with RUT-based H.pylori detection.RESULTS A total of 198 patients were prospectively enrolled in an H.pylori diagnostic study by Endofasterbased gastric juice analysis(EGJA)during the UGE.Biopsies for RUT and histological assessment were performed on 161 patients(82 men and 79 women,mean age 54.8±19.2 years).H.pylori infection was detected by histology in 47(29.2%)patients.Overall,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value(NPV)for H.pylori diagnosis by EGJA were 91.5%,93.0%,92.6%,84.3%,and 96.4%,respectively.In patients on treatment with proton pump inhibitors,diagnostic sensitivity was reduced by 27.3%,while specificity and NPV were unaffected.EGJA and RUT were comparable in diagnostic performance and highly concordant in H.pylori detection(κ-value=0.85).CONCLUSION Endofaster allows for rapid and highly accurate detection of H.pylori during gastroscopy.This may guide taking additional biopsies for antibiotic susceptibility testing during the same procedure and then selecting an individually tailored eradication regimen. | Riccardo Vasapolli Florent Ailloud Sebastian Suerbaum Jens Neumann Nadine Koch Lukas Macke Jörg Schirra Julia Mayerle Peter Malfertheiner Christian Schulz | 2023 | World Journal of Gastroenterology2023，29，10： | 1 |
| 14 | Microglia provide neuroprotection after ischemia 显示文摘 | Jens Neumann Matthias Gunzer Gutzeit H O | 2006 | FASEB2006，20，： | 1 |
| 15 | Interdisciplinary management of central nervous system metastasis and neoplastic meningitis:recent developments and future perspectives显示文摘The incidence of metastatic disease in the central nervous system(CNS)is rising.According to current estimates,up to a third of adult cancer patients will suffer from CNS metastasis.Clinical evidence-based data from prospective randomized trials are rare,however,because CNS metastasis patients were often excluded from clinical trial participation.The management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary challenge.Recent basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the CNS.This report reviews advances,challenges,and perspectives in this field. | Ghazaleh Tabatabai Marilin Koch Cristiana Roggia Juliane Ebert Claus Garbe Friedegund Meier Sara Brucker Eva Maria Grischke Diethelm Wallwiener Robert Möhle Lothar Kanz Walter Erich Aulitzky Ulrike Ernemann Christian laFougere Konstantin Nikolaou Bernd Pichler Jens Schittenhelm Manuela Neumann Falko Fend Stefan Czemmel Sven Nahnsen Frank Paulsen Daniel Zips Maike van Lessen Hans-Otto Karnath Ulf Ziemann Constantin Roder Marco Skardelly Jürgen Bernd Honegger Marcos Tatagiba | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
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