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| 1 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism显示文摘BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a global metabolism-associated liver disease.Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a newly discovered secreted protein that is involved in metabolic homeostasis.However,much remains to be discovered about its function in hepatic lipid metabolism;thus,we assessed whether MANF could regulate hepatic metabolism.AIM To establish in vivo and in vitro NAFLD models to explore the role of MANF in hepatic lipid metabolism.METHODS HepG2 cells treated with free fatty acids (FFAs) and ob/ob mice were used as NAFLD models.Liver tissues collected from wild type and ob/ob mice were used to detect MANF expression.Cells were treated with FFAs for different durations.Moreover,we used lentiviral constructs to establish overexpression and knockdown cell models in order to interfere with MANF expression levels and observe whether MANF influences hepatic steatosis.Western blot analysis and quantitative real-time PCR were used to detect protein and gene expression,and oil red O staining was used to visualize intracellular lipid droplets.RESULTS Hepatic MANF protein and mRNA expression in wild type mice were 10-fold and 2-fold higher,respectively,than those in ob/ob mice.The MANF protein was temporarily increased by 1.3-fold after stimulation with FFAs for 24 h and gradually decreased to 0.66-fold that of the control at the 72 h time point in HepG2 cells.MANF deficiency upregulated the expression of genes involved infatty acid synthesis,cholesterol synthesis,and fatty acid uptake and aggravated HepG2 cell steatosis,while MANF overexpression inhibited fatty acid synthesis and uptake and cholesterol synthesis,and rescued HepG2 cells from FFAsinduced steatosis.Furthermore,a significant decrease in triglyceride levels was observed in the MANF overexpression group compared with the control group(0.4288±0.0081 mmol/g vs 0.3746±0.0121 mmol/g,P <0.05) upon FF As treatment.There was also a 17%decrease in intracellular total cholesterol levels between the MANF overexpression group and the control group (0.1301±0.0059mmol/g vs 0.1088±0.0009 mmol/g,P <0.05) upon FF As treatment.Moreover,MANF suppressed lipid deposition in HepG2 cells.CONCLUSION Our findings indicate that MANF improves the phenotype of liver cell steatosis and may be a potential therapeutic target in hepatic steatosis processes. | Miao He Cong Wang Xiao-Hong Long Jia-Jia Peng Dong-Fang Liu Gang-Yi Yang Michael D Jensen Li-Li Zhang | 2020 | World Journal of Gastroenterology2020，26，10： | 3 |
| 4 | Subpixel edge localization and the interpolation of still images 显示文摘 | Jensen K Anastassiou D | 1995 | IEEE Transactions on Image Processing1995，14，3： | 2 |
| 5 | Characterization of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimutium DT104显示文摘 | Sandvang D Aarestrup F M Jensen L B | 1997 | FEMS Microbiol Lett1997，157，1： | 2 |
| 6 | Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review显示文摘Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches. | Sabine Gerum Alexandra D Jensen Falk Roeder | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 2 |
| 7 | Characterization of the dissolved organic carbon in landfill leachatepolluted groundwater 显示文摘 | Christensen J B Jensen D L Gron C | 1998 | Wat Res1998，32，1： | 1 |
| 8 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 9 | Adaptations to environmental stresses显示文摘 | Hans J Bohnert Nelson D E Jensen R G | 1995 | Plant cell1995，7，： | 1 |
| 10 | Experimental study of char thermal deactivation显示文摘 | ZOLIN A JENSEN A D JENSEN P A DAM-JOHANSEN K | 2002 | Fuel2002，81，8： | 1 |
| 11 | Treatment of waste incinerator air-pollution-control residues with FeSO4:concept and product characterization显示文摘 | LUNDTORP K JENSEN D L SORENSEN M A | 2002 | Waste Management and Research2002，20，： | 1 |
| 12 | Genetic diversity of the attachment(H)protein gene of current field isolates of canine distemper cirus显示文摘 | Bolt G Jensen T D Gottschalck E | 1997 | J Gen Virol1997，78，： | 1 |
| 13 | Expression of surfactant associ-ated protein-A and Clara cell 10 kilodahon mRNA in neoplastic and non-neoplastichuman lung tissue as detected by in situ hybridization 显示文摘 | Broers J L Jensen S M Travis W D | 1992 | Lab Invest1992，66，3： | 1 |
| 14 | Population studies of Trichodermaharzianum and Pythium spp and biological control of damping - off and root rot of cucumber in peat following substrate amendment with oatmeal显示文摘 | Green H Jensen D F | 1992 | Bulletin Oilbsrop1992，15，1： | 1 |
| 15 | Formation and reduction of nitric oxide in fixed-bed combustion of straw显示文摘 | Zhou H Jensen A D Glarborg P | 2006 | Fuel2006，85，56： | 1 |
| 16 | Deactivation of V2 05- WO3-TiO2 SCR catalyst at a biomass-fired combined heat and power plant 显示文摘 | Zheng Y J Jensen A D Johnsson J E | 2005 | Applied Catalysis B : Environmental2005，60，： | 1 |
| 17 | A unified framework for addiction: vulnerabilities in the de- cision process 显示文摘 | Reddish A D Jensen S Johnson A | 2008 | Behavioral and Brain Sciences2008，31，4： | 1 |
| 18 | Deactivation of V205 -W03 - Ti02 SCR catalyst at biomass fired power plants : Elucidationof mechanisms by lab - and pilot - scale experiments显示文摘 | ZhengY Jensen A D Johnsson J E | 2008 | AppliedCatalysis B : Environmental2008，83，34： | 1 |
| 19 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 20 | Physically Based Modeling and Animation of Fire 显示文摘 | Nguyen D Q Ronald F Jensen H W | 2002 | ACM Transactions on Graphics2002，21，3： | 1 |
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