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| 1 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 2 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 3 | Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg, Survey 4 (KORA S4) 显示文摘 | HERDER C KOLB H KOENIG W | 2006 | Diabetes Care2006，29，2： | 1 |
| 4 | Epidemiology of chronic kidney disease: results from a population of older adults in Germany 显示文摘 | Zhang QL Koenig W Raum E | 2009 | Prey Med2009，48，2： | 1 |
| 5 | Quality definitions and assessment in drilling of fiher reinforced thermoses显示文摘 | W Koenig P Grab | 1989 | Ann CIRP1989，38，1： | 1 |
| 6 | Lipoprotein-associated phespholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population : results from the 14-year follow-up of a large cohort from southern Germany显示文摘 | Koenig W Khuseyinova N Lowel H | 2004 | Circulation2004，110，： | 1 |
| 7 | Comparison of N - terminal pro- B - natriuretic peptide, C - reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease 显示文摘 | Rothenbacher D Koenig W Brenner H | 2006 | Arch Intern Med2006，166，22： | 1 |
| 8 | Cystatin C and cardiovascular risk 显示文摘 | Taglieri N Koenig W Kaski JC | 2009 | ClinChem2009，55，11： | 1 |
| 9 | Die Bedeutung der Regenwasserbewirtschaftung显示文摘 | Klaus W Koenig | 2003 | Umweltpraxis2003，，1： | 1 |
| 10 | Cystain C and cardiovascular risk 显示文摘 | Taglier N Koenig W Kaski JC | 2010 | Ann Biol Clin(Pails)2010，68，5： | 1 |
| 11 | Plasma fibrin D - dimer levels and risk of stable coronary artery disease results of a large case - control study 显示文摘 | Koenig W Rotbenbacher D Hoffmeister A | 2001 | Arterioscl Thromb Vascul Biolo2001，21，10： | 1 |
| 12 | Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events:more than simply a marker of glomerular filtration rate显示文摘 | Koenig W Twardella D Brenner H | 2005 | Clin Chem2005，51，2： | 1 |
| 13 | The Release of Alginate Lyase from Growing Pseudomonas syringae pathovar phaseolicola显示文摘 | OTT C M DAY D F KOENIG D W | 2001 | Current Microbiology2001，42，2： | 1 |
| 14 | C- reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992显示文摘 | Koenig W Sund M Froblich M | 1999 | Circulation1999，99，2： | 1 |
| 15 | Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C reactive protein in apparently healthy middleaged men from the general population:results from the 14-year follow up of a large cohort from southern Germany显示文摘 | Koenig W Khuseyinova N Lowel H | 2004 | Circulation2004，110，： | 1 |
| 16 | C-reactive protein modulates risk prediction based on the Framingham score:implications for future risk assessment:resuits from a large cohort study in southern Germany 显示文摘 | Koenig W Lowel H Baumert J | 2004 | Circulation2004，109，： | 1 |
| 17 | Association of systemic coneent rations of macrophage migration inhibitory factor with impaired glucose tole-rance and type 2 diabetes:results from the Cooperative Health Research in the Region of Angsburg,Survey 4 (KORA S4)显示文摘 | Herder C Kolb H Koenig W | 2006 | Diabetes Care2006，29，2： | 1 |
| 18 | Serum amyloid P component and cardiovascular disease:is there a sensible link 显示文摘 | Koenig W | | 0，，04： | 1 |
| 19 | High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy显示文摘 | Koenig W | 2013 | Int J Cardiol2013，68，： | 1 |
| 20 | Utility of inflammatory markers in the management of coronary artery disease 显示文摘 | Rosenson RS Koenig W | 2003 | Am J Cardiol2003，92，1： | 1 |
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