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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3h5obxnwu6uou66n5u.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Molecular-dynamics calculations of the velocity-autocorrelation function:methods,hard-disk results显示文摘 | JEROME J E WILLIAM W W | 1982 | Phys Rev:A1982，26，3： | 1 |
| 5 | The development and potential application of Pb-Al alloy显示文摘 | Cole Jerome F Coodwin Frank E | 1990 | JOM1990，，6： | 1 |
| 6 | Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human Ulnar Mammary syndrome显示文摘 | Daven pont T G Jerome Majewska L A Papaioannou V E | 2003 | Development2003，130，10： | 1 |
| 7 | The Role of Personal Values in Marketing and Consumer Behavior显示文摘 | DONALD E VINSON JEROME E SCOTT LAWRENCE M LAMONT | 1977 | The Journal of Marketing1977，41，2： | 1 |
| 8 | Cyclic behavior of steel frame structures with composite reinforced concrete infill walls and partiallyrestrained connections显示文摘 | Tong Xiangdong Hajjar Jerome F Arturo E | 2005 | Journal of Constructional Steel Research2005，61，4： | 1 |
| 9 | Behavior of shear studs in steel frames with reinforced concrete infill walls 显示文摘 | Saari W K Jerome F H Schultz A E | 2004 | Journal of Constructional Steel Research2004，60，4： | 1 |
| 10 | Coor- dinate repression of regulators of embryonic identity by PICK- LE during germination in Arabidopsis显示文摘 | DEAN R S HENDERSON J T JEROME R E | 2003 | Plant J2003，35，1： | 1 |
| 11 | Acute cardiovascular ex- ercise and executive control function显示文摘 | HILLMAN C H SNOOK E M JEROME G J | 2003 | International Journal of Psycho- physiology2003，48，3： | 1 |
| 12 | Coordinate repression of regulators of embryonic identity by PICK- LE during germination in Arabidopsis 显示文摘 | Dean Rider S Jr Henderson J T Jerome R E | 2003 | Plant J2003，35，1： | 1 |
| 13 | Role of through space 2p-3d overlap in the alkylation ofphosphines 显示文摘 | William E McEwen Blair Janes A Jerome W Knapczyk | 1978 | J Am ChemSoc1978，100，23： | 1 |
| 14 | Special issue on computational social choice 显示文摘 | EDITH E JEROME L | 2011 | Autonomous Agents and Multi-Agent Systems2011，22，1： | 1 |
| 15 | Triple-negative breast cancers are increased in black women regardless of age or body mass index 显示文摘 | Lesley A Stead Timothy L Lash Jerome E Sobieraj | 2009 | Breast Cancer Res2009，11，2： | 1 |
| 16 | Exposure to glycol ethers in a population of French men evaluated by measurement of urinary alkoxycarboxylie acids 显示文摘 | Ben-Brik E Jerome L Amaud I | 2004 | International Archives of Occupational and Environmental Health2004，77，： | 1 |
| 17 | Coronavirus replication complex formation utilizes components of cellular autophagy显示文摘 | Prentice E Jerome W G Yoshimori T | 2004 | J Biol Chem2004，279，10： | 1 |
| 18 | An Assessment of MERIS Algal Products during an Intense Bloom in Lake of the Woods显示文摘 | Binding C E Greenberg T A Jerome J H | 2011 | Journal of Plankton Research2011，33，5： | 1 |
| 19 | Robust LQR Controller Design for Stabili- zing and Trajectory Tracking of Inverted Pendulum显示文摘 | V Kumar E Jerome J | 2013 | Procedia Engineering2013，，： | 1 |
| 20 | Controlled Ring- OpeningPolymerization of e- Caprolactone Promoted by ' in Situ' Formed Yttrium Alkoxides显示文摘 | Martin E Dubois P Jerome R | 2000 | Macromolecules2000，33，5： | 1 |
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