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| 1 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 2 | Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study显示文摘 | Mats Lindblad Luis A. García Rodríguez Jesper Lagergren | 2005 | Cancer Causes & Control2005，，3： | 3 |
| 3 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Int J Cancer2012，，6： | 2 |
| 4 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 5 | Increased Risk of Colorectal Cancer After Obesity Surgery显示文摘 | Maryam Derogar Mark A. Hull Prashant Kant Magdalena ?stlund Yunxia Lu Jesper Lagergren | 2013 | Annals of Surgery2013，，6： | 1 |
| 6 | Changes in prevalence, incidence and spontaneous loss of gastro-oesophageal reflux symptoms: a prospective population-based cohort study, the HUNT study显示文摘 | Eivind Ness-Jensen Anna Lindam Jesper Lagergren Kristian Hveem | 2012 | Gut2012，，： | 1 |
| 7 | Complications after percutaneous endoscopic gastrostomy in a prospective study显示文摘 | John Blomberg Jesper Lagergren Lena Martin Fredrik Mattsson Pernilla Lagergren | 2012 | Scandinavian Journal of Gastroenterology2012，，6： | 1 |
| 8 | Risk Factors for Esophageal Adenocarcinoma After Antireflux Surgery显示文摘 | Hedvig E. L?fdahl Yunxia Lu Pernilla Lagergren Jesper Lagergren | 2013 | Annals of Surgery2013，，： | 1 |
| 9 | Is Esophageal Adenocarcinoma Occurring Late After Antireflux Surgery Due to Persistent Postoperative Reflux?显示文摘 | Jesper Lagergren MD PhD Pernilla Viklund RN | 2007 | World Journal of Surgery2007，，3： | 1 |
| 10 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Int. J. Cancer2012，，6： | 1 |
| 11 | Increased Risk of Barrett’s Esophagus Among Individuals Born Preterm or Small for Gestational Age显示文摘 | Lina Forssell Sven Cnattingius Matteo Bottai Anna–Karin Edstedt Bonamy Jesper Lagergren Lars Agréus Olof Akre | 2013 | Clinical Gastroenterology and Hepatology2013，，7： | 1 |
| 12 | Population-based esophageal cancer survival after resection without neoadjuvant therapy: An update显示文摘 | Martin Ruteg?rd Konstantinos Charonis Yunxia Lu Pernilla Lagergren Jesper Lagergren Ioannis Rouvelas | 2012 | Surgery2012，，5： | 1 |
| 13 | Risk of Esophagitis Among Individuals Born Preterm or Small for Gestational Age显示文摘 | Lina Forssell Sven Cnattingius Matteo Bottai Jesper Lagergren Anders Ekbom Olof Akre | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 1 |
| 14 | Risk of oesophageal adenocarcinoma among individuals born preterm or small for gestational age显示文摘 | Forssell Lina Cnattingius Sven Bottai Matteo Edstedt Bonamy Anna-Karin Lagergren Jesper Agréus Lars Akre Olof | 2013 | European Journal of Cancer2013，，9： | 1 |
| 15 | Gastric stump cancer after distal gastrectomy for benign gastric ulcer in a population‐based study显示文摘 | Jesper Lagergren Anna Lindam Robert M. Mason | 2012 | Cancer2012，，6： | 1 |
| 16 | Risk Factors for Complications After Esophageal Cancer Resection: A Prospective Population-Based Study in Sweden显示文摘 | Pernilla Viklund Mats Lindblad Ming Lu Weimin Ye Jan Johansson Jesper Lagergren | 2006 | Annals of Surgery2006，，2： | 1 |
| 17 | 阻止 hyperenzymemia 在以后的 Losartan 内视镜后退 cholangiopan-creatography: 使随机化的临床的试用显示文摘 AIM: To study if the angiotensin Ⅱ receptor blockers (ARB) losartan counteracts pancreatic hyperenzymemiaas measured 24 h after endoscopic retrograde cholan-giopancreatography (ERCP).METHODS: A triple-blind and placebo-controlled ran-domized clinical trial was performed at two Swedish hospitals in 2006-2008. Patients over 18 years of age undergoing ERCP, excluding those with current pancreatitis, current use of ARB, and severe disease, such as sepsis, liver and renal failure. One oral dose of 50 mg losartan or placebo was given one hour before ERCP. The relative risk of hyperenzymemia 24 h after ERCP was estimated using multivariable logistic regression, and expressed as odds ratio with 95% confidence intervals (CIs), including adjustment for potential remaining confounding.RESULTS: Among 76 participating patients, 38 were randomized to the losartan and the placebo group, re-spectively. The incidence rates of hyperenzymemia and acute pancreatitis among all 76 participating patients were 21% and 12%, respectively. Hyperenzymemia was detected in 9 and 7 patients in the losartan and placebo group, respectively. There were no major differences between the comparison groups regarding cannulation difficulty, findings, or proportion of patients requiring drainage of the bile ducts. There were, how-ever, more pancreatic duct injections, a greater extent of pancreatography, and more biliary sphincterotomies in the losartan group than in the placebo group. Losar-tan was not associated with risk of hyperenzymemia compared to the placebo group after multi-varible logis-tic regression analysis (odds ratio 1.6, 95%CI 0.3-7.8).CONCLUSION: In this randomized trial 50 mg losartan given orally had no prophylactic effect on development of hyperenzymemia after ERCP. | Tomas Sjberg Bexelius John Blomberg Hans-Olof Hkansson Peter Mller Carl-Eric Nordgren Urban Arnelo Jesper Lagergren Mats Lindblad | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，11： | 1 |
| 18 | Recent developments in esophageal adenocarcinoma显示文摘 | Jesper Lagergren Pernilla Lagergren | 2013 | CA A Cancer Journal for Clinicians2013，，4： | 1 |
| 19 | Risk Factors for Esophageal Adenocarcinoma After Antireflux Surgery显示文摘 | Hedvig E. L?fdahl Yunxia Lu Pernilla Lagergren Jesper Lagergren | 2013 | Annals of Surgery2013，，4： | 1 |
| 20 | 对于重度胃食管反流病,何种治疗方式最有效?显示文摘概述
胃食管反流病(gastro—oesophagealreflux disease,GORD)的定义是指因胃内容物反流而引起不适症状和(或)其他并发症。GORD可分为轻度和重度,重度是指患者与反流相关的症状严重和(或)产生并发症。 | John Maret-Ouda Nele Brusselaers Jesper Lagergren 朱佳杰 魏玮 | 2016 | 英国医学杂志中文版2016，0，7： | 0 |
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