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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Muscle force and movement variability before and after total knee arthroplasty: A review显示文摘Variability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthritis(OA), but the question of whether the same correlations also apply to those who have undergone a surgical intervention such as total knee arthroplasty(TKA) is still being investigated. While there is a growing body of literature identifying potential rehabilitation targets for individuals who have undergone TKA, it is important to first understand the underlying post-operative impairments to more efficiently target functional deficits that may lead to improvedlong-term outcomes. The purpose of this article is to review the potential role of muscle force output and movement variability in TKA recipients. The narrative review relies on existing literature in elderly healthy and impaired individuals, as well as in those with OA before and following TKA. The variables that may predict longterm functional abilities and deficits are discussed in the context of existing literature in healthy older adults and older adults with OA and following TKA, as well as the role future research in this field may play in providing evidence-based data for improved rehabilitation targets. | Jessica W Smith Jesse C Christensen Robin L Marcus Paul C LaStayo | 2014 | World Journal of Orthopedics2014，5，2： | 3 |
| 3 | Risk of colorectal cancer in patients with ulcerative colitis:a meta-analysis of population-based cohort studies显示文摘 | Jess T Rungoe C Peyrin-Biroulet L | 2012 | Clin Gastroenterol Hepatol2012，10，6： | 1 |
| 4 | Management of radial head fractures:current concepts显示文摘 | Laurens Kaas Jesse B Jupiter C | | 0，，01： | 1 |
| 5 | Management of radial head fractures: current concepts 显示文摘 | Laurens Kaas Jesse B Jupiter C | 2011 | Shoulder & Elbow2011，3，： | 1 |
| 6 | H4stogenesis of giant cell tumors 显示文摘 | Wuelling M Engels C Jesse N | 2002 | Pathologe2002，23，5： | 1 |
| 7 | Risk of colorectal cancer in patients with ulcerative colitis: a meta - analysis of population - based cohort studies 显示文摘 | Jess T Rungoe C Peyrin - Biroulet 1 | 2012 | Clin Gastroenterol Hepatol2012，10，6： | 1 |
| 8 | Metal - organic frameworks: A new class of porous materials 显示文摘 | Jesse L C Rowsell Omar M Y | 2004 | Microporous and Mesoporous Materials2004，73，12： | 1 |
| 9 | Anatomic and technical considera- tions for optimizing recovery of sexual function during robotic-as- sisted radical prostatectomy 显示文摘 | Stacey C Jesse DL Jim CH | 2013 | Curr Opin Urol2013，23，： | 1 |
| 10 | Olfactory function and disease severi- ty in chronic rhinosinusitis 显示文摘 | Litvack JR Jess C Smith TL | 2009 | Rhinol Allergy2009，23，2： | 1 |
| 11 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 12 | Histogenesis of giant cell tumors显示文摘 | Wuelling M Engels C Jesse N | 2002 | Pathologe2002，23，5： | 1 |
| 13 | Production of butanol from starch-based waste packing peanuts and agricultural waste 显示文摘 | Jesse T W Ezeji T C Qureshi N | 2002 | J Ind Microbiol Biotechno12002，29，3： | 1 |
| 14 | Nitrogen retention,ovulation rate,and hormonal profiles in gilts fed a high-protein diet显示文摘 | MURRY A C JESSE G W VEUM T L | 1998 | The Professional Animal Scientist1998，14，2： | 1 |
| 15 | ESCA characterization of fluoropolymer film residue on carbon-fiber-reinforced plastic components显示文摘 | JESSE T C DAVID G C | 2000 | Surface and Interface Analysis2000，29，11： | 1 |
| 16 | Risk of colorectal cancer in pa- tients with ulcerative colitis : a meta-analysis of population-based cohort studies 显示文摘 | Jess T Rungoe C Peyrin-Biroulet L | 2012 | Clin Gastroenterol Hepatol2012，10，6： | 1 |
| 17 | Thoracolumbar spinal manipulation and the immediate impact on exercise performance显示文摘 | John S Jesse C Michael R | 2012 | J Chiropr Med2012，11，4： | 1 |
| 18 | Influence of chemical reaction rate,diffusion and pore structure on the regeneration of a coked Al2O3-catalyst显示文摘 | KERN C JESS A | 2004 | Appl Catal A2004，272，12： | 1 |
| 19 | Regeneration of coked catalysts-modeling and verification of coke burn-off in single particles and fixed bed reactors显示文摘 | JESS A | 2005 | Chem Eng Sci2005，60，15： | 1 |
| 20 | Effect of supplemental potassium in the receiving diet and form of antibiotic on feeder pig performance 显示文摘 | Jesse G W Walker J R Weiss C N | 1988 | J Anita Sci1988，66，： | 1 |
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