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| 1 | Sensing Sulfur Conditions: Simple to Complex Protein Regulatory Mechanisms in Plant Thiol Metabolism显示文摘硫是必要的因为植物生长和开发,和为维持硫和 thiol 新陈代谢的分子的系统紧被控制。从一个生物化学的观点,植物 thiol 新陈代谢的规定加亮自然的能力设计在条件的一个范围下面对多重输入和细胞的要求作出回应的小径。在这评论,我们集中于形成生物化学的硫由把包含硫的混合物的细胞内部的集中翻译成关键新陈代谢的步骤的控制在植物察觉到的分子的基础的规章的机制。这些机制从简单(底层可获得性,反应的热力学的性质,反馈抑制,和细胞器本地化) 到精致(multienzyme 建筑群和基于 thiol 的氧化还原作用开关的形成) 。最终,这些规章的系统的动态相互影响为在植物察觉到并且维持硫吸收和 thiol 新陈代谢是批评的。 | Hankuil Yi Ashley Galant Geoffrey E. Ravilious Mary L. Preuss Joseph M. Jez | 2010 | Molecular Plant2010，3，2： | 4 |
| 2 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Identification, characterization, epitope mapping, and three-dimensional modeling of the α-subunit of β-conglycinin of soybean, a potential allergen for young pigs显示文摘 | FU C J JEZ J M KERLEY M S | 2007 | J Agric Food Chem2007，55，10： | 1 |
| 4 | Structure of chalcone synthase and the molecular basis of plant polyketide 显示文摘 | Ferrer J Jez J Bowman M | 1999 | Nat Struct Biol1999，，6： | 1 |
| 5 | Identification, characterization, epitope mapping, and three-dimensional modeling of the alpha-subunit of beta-conglycinin of soybean, a potential allergen for young pigs显示文摘 | FU C J J JEZ J M KERLEY M S | 2007 | Journal of Agricultural and Food Chemistry2007，55，： | 1 |
| 6 | Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis 显示文摘 | Ferrer J L Jez J M Bowman M E | 1999 | Nat Struct Biol1999，6，： | 1 |
| 7 | Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesus显示文摘 | Ferrer J Jez J Bowman M | 1999 | Nat Struct Biol1999，6，： | 1 |
| 8 | A nomenclature system for the aldo- keto reductase superfamily显示文摘 | Jez JM Flynn TG Penning TM | 1997 | Adv Exp Med Biol1997，414，： | 1 |
| 9 | Performance of bioaugmentation-assisted phytoextraction applied to metal contaminated soils: Areview显示文摘 | Lebeau T Braud A Jez^quel K | 2008 | Environmental Pollution2008，153，： | 1 |
| 10 | Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase显示文摘 | Bowman M E Dixon RA | 2000 | Nature structural biology2000，7，9： | 1 |
| 11 | The aldo-keto reductase(AKR) superfamily: an update显示文摘 | Jez JM Penning TM | 2001 | Chem Biol Interact2001，，13： | 1 |
| 12 | Novel renovated silver ring electrode for anodic stripping analysis of Pb(Ⅱ) and Cd(Ⅱ) traces in water samples without removal of oxygen and surfactants显示文摘 | Bas' B Jakubowska M Jez M | 2010 | J Electroanal Chem2010，638，： | 1 |
| 13 | Comparative anatomy of the aldo-keto reductase superfamily显示文摘 | Jez J M Bennett M J Schlegel B P | 1997 | Biochemical Journal1997，326，2： | 1 |
| 14 | Dissection of malonyl-coenzyme a decarboxylation from polyketide for marion in the reaction mechanism of a plant polyketide synthase显示文摘 | JEZ J M FERRER J L BOWMAN M E DIXON R A NOEL J P | 2000 | Biochemistry2000，39，5： | 1 |
| 15 | Compara-tive anatomy of the aldo-keto reductase superfamily显示文摘 | Jez J M Monbouquette H G Schroder I | 1997 | Biochem J1997，326，： | 1 |
| 16 | Structure and mechanism of the evolutionarily unique plant enzyme chalcoe isomerase显示文摘 | JEZ J M BOWMAN M E DIXON R A | 2000 | Nat Struct Biol2000，7，： | 1 |
| 17 | Human 3alpha-hydroxysteroid dehydrogenase isoforms (akr1c1-akr1 c4) of the aldo-keto reductase superfamily:Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones显示文摘 | Penning TM Burczynski ME Jez JM | | 0，，： | 1 |
| 18 | Identification, charac- terization, epitope mapping, and three-dimensional mod- eling of the ct-subunit of fl-conglycinin of soybean, a po- tential allergen for young pigs 显示文摘 | FU C J Jez J M Kerley M S | 2007 | Journal of Agricultural and Food Chemistry2007，55，10： | 1 |
| 19 | A New Microresistivity Imaging Device for use in Non-Conductive and Oil-Based Muds显示文摘 | Jez Lofts | 2002 | Petrophysics2002，44，5： | 1 |
| 20 | Structure of chalcone syn- thase and the molecular basis of plant polyketide biosynthesis 显示文摘 | Ferrer J L Jez J M Bowman M E | 1999 | Nat Struct Biol1999，6，： | 1 |
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