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您的检索式：作者名="Jiafang Deng"
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| 1 | Hydrothermal evolution and source of metallogenic materials of Beiya Au polymetallic deposit,western Yunnan,China显示文摘The Beiya porphyry-skarn gold-polymetallic deposit is one of the largest gold deposits in China and it also contains significant amounts of silver and base metals.The ore-bearing monzonitic granite porphyry occurs as a stock,of which the skarn type gold-copper-iron ore bodies are controlled by the contact zone between alkali-rich monzonitic granite porphyry and the limestone,and the gold-silver polymetallic mineralization is controlled by interlayer structure.Alteration and mineralization occur around the intrusion and exterior of monzonitic granite porphyry.Ore mineral formation sequence is as follows:skarn minerals→magnetite→pyrite→chalcopyrite/bornite+pyrite+gold→pyrite+galena+gold(silver).Petrographic studies of fluid inclusions indicate that the following types of inclusions exist in the pre-mineralization quartz-pyrite stage:gas-liquid two-phase inclusions(L-type),three-phase inclusions with daughter minerals(D-type)and gas-rich inclusions(V-type).The colorless transparent quartz in the main gold-chalcopyrite-pyrite stage mainly consists of L-type and V-type inclusions,whereas the inclusions in the late gold-silver-galena stage are mainly L-type.The evolution of ore-forming fluids shows a trend from high temperature,high salinity to medium-low temperature and low salinity.Medium-low density fluids play a dominant role in mineral component migration and transportation.Fluid cooling and boiling are the main mechanisms of gold-copper precipitation,while the involvement of atmospheric water and pH reduction are the main mechanisms of gold-silver polymetallic precipitation.The fluids in the quartz-pyrite stage before mineralization and the main gold-chalcopyrite-pyrite stage are dominated by magmatic water,while in the gold-silver-galena stage the fluids are dominated by atmospheric water.Isotope tracers show that S and Pb are mainly derived from monzonitic granite porphyry,not from limestone of the Beiya Formation. | DENG Jiafang SUN Fengyue XIN Wei XU Zhihe PAN Zhongcui WU Dongqian TIAN Nan | 2020 | Global Geology2020，23，2： | 1 |
| 2 | Targeted Degradation of DNA/RNA Binding Proteins via Covalent Hydrophobic Tagging显示文摘Targeted protein degradation(TPD)holds great promise for biological inquiry and therapeutic development.However,it still remains elusive to destruct DNA/RNA binding proteins(DBPs/RBPs)previously deemed undruggable.Herein,we report ligandassisted covalent hydrophobic tagging(LACHT)as a modular strategy for TPD of these difficult-totarget proteins.Guided by a noncovalent protein ligand,LACHT leverages a reactive N-acyl-N-alkyl sulfonamide group to covalently label the protein target with a hydrophobic adamantane,which further engages the cellular quality control mechanism to induce proteolytic degradation.Using a smallmolecule ligand,we demonstrated that LACHT allowed TPD of a DBP,bromodomain-containing protein 4,in human leukemia cells with high efficiency.Mechanistic studies revealed that LACHT-mediated TPD dependent on ligand-directed irreversible tagging and the covalently labeled proteins underwent polyubiquitination before removal through both the proteasome and the lysosome.Furthermore,when an RNA ligand was employed,we showed that LACHT also enabled TPD of an RBP,Lin28a,leading to upregulation of its downstream let-7 miRNA.This study thus provides a generalizable platform to expand the TPD toolbox for biomedical applications. | Yan Wang Jingzi Zhang Jiafang Deng Chengzhi Wang Lei Fang Yan Zhang Jinbo Li | 2023 | CCS Chemistry2023，5，10： | 0 |
| 3 | 3D printing of plasmonic nanofocusing tip enabling high resolution,high throughput and high contrast optical near-field imaging显示文摘Scanning near-field optical microscopy(SNOM)offers a means to reach a fine spatial resolution down to~10 nm,but unfortunately suffers from low transmission efficiency of optical signal.Here we present design and 3D printing of a fiber-bound polymer-core/gold-shell spiral-grating conical tip that allows for coupling the inner incident optical signal to the outer surface plasmon polariton with high efficiency,which then adiabatically transport,squeeze,and interfere constructively at the tip apex to form a plasmonic superfocusing spot with tiny size and high brightness.Numerical simulations and optical measurements show that this specially designed and fabricated tip has 10%transmission efficiency,~5 nm spatial resolution,20 dB signal-to-noise ratio,and 7000 pixels per second fast scanning speed.This high-resolution,high throughput,and high contrast SNOM would open up a new frontier of high spatial-temporal resolution detecting,imaging,and monitoring of single-molecule physical,chemical,and biological systems,and deepen our understanding of their basic science in the single-molecule level. | Li Long Qiurong Deng Rongtao Huang Jiafang Li Zhi-Yuan Li | 2023 | Light(Science & Applications)2023，12，10： | 0 |
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