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| 1 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Interaction between α-calcium sulfate hemihydrate and superplasticizer from the point of adsorption characteristics, hydration and hardening process显示文摘 | Baohong Guan Qingqing Ye Jiali Zhang Wenbin Lou Zhongbiao Wu | 2009 | Cement and Concrete Research2009，，2： | 1 |
| 3 | New insights into the carotenoid biosynthesis in Torreya grandis kernels显示文摘Torreya grandis is a characteristic rare economic tree species in subtropical mountainous areas. The nut has a variety of bioactive compounds, such as polyphenols and vitamins. However, the carotenoids compositions and its regulatory mechanisms underlying carotenoid biosynthesis in kernels remain unknown. Here, the major carotenoids in the kernel were analyzed. The result showed that lutein and β-carotene were the predominant carotenoids in the kernel, while low levels of a-carotenoid and zeaxanthin were detected. Lutein and β-carotene were decreased during the maturation of kernel. Expression analysis by RNA-seq and q RT-PCR indicated that the expressions of TgCYP97A3 and TgLCYB were also reduced during the maturation of kernel. The contents of lutein or β-carotene were obviously increased in tobacco transiently overexpressing TgCYP97A3 or TgLCYB. Moreover, DPPH radical scavenging activity and FRAP were also significantly enhanced. In addition, several MYB and WRKY transcription factors TgMYBS3, TgMYB48 and TgWRKY11 were identified to positively regulate the TgCYP97A3 expression, while TgMYB48, TgWRKY2 and TgWRKY11 could upregulate the TgLCYB expression. The illustration of carotenoids biosynthesis and its molecular mechanism in kernels not only provides a basis for understanding carotenoids biosynthesis in kernels, but also enables the use of molecular biotechnology to develop new health products rich in carotenoids based on T. grandis nuts. | Jingwei Yan Hao Zeng Weijie Chen Jiali Luo Congcong Kong Heqiang Lou Jiasheng Wu | 2023 | Horticultural Plant Journal2023，9，6： | 0 |
| 4 | The Influence of Age on Blood Flow and Temperature of Acupuncture Points: A Study based on Laser Doppler Flowmetry and Infrared Thermography显示文摘Background:To date,there has been a great lack of investigation on the influence of age on blood flow and temperature of acupoints in specific regions.Objective:This study aimed to determine the association between different age categories and acupoint blood flow/temperature on the forearm.Methods:Acupoint blood flow and temperature were measured in healthy adults of different age categories using laser doppler flowmetry(LDF)and infrared thermography(IRT),respectively.A total of 60 eligible healthy volunteers were divided into the young group,mid age group and old age group.All groups received LDF and IRT examination.Shenmen(HT7),Shaohai(HT3),Taiyuan(LU9)and Chize(LU5)of the Heart and Lung meridians on the forearm were selected as 4 test acupoints.Results:Regarding blood flow of the 4 test acupoints,the PU of Taiyuan(LU9)in the old age group was sig-nificantly different compared with that of the young age group(P<0.05)and the mid age group(P<0.05),while there was no significant difference in PU of the other acupoints between 3 groups(all P>0.05).Simi-larly,regarding acupoint temperature of the 4 test sites,the temperature of Shaohai(HT3)in the old age group was significantly different compared with that of the mid age group(P<0.05),while there was no significant difference in the temperature of the other 3 acupoints between 3 age groups(all P>0.05).Conclusion:Age category tends to have notable influence on the blood flow and temperature in specific acupoints in the forearm.Therefore,particular concerns should be taken into consideration regarding the effect of age differences for future studies in this field.Nevertheless,further studies with a large sample size and more test acupoints are needed to further verify current findings. | Yajun Zhang Xiaoyu Li Xiaofen He Yongliang Jiang Hantong Hu Jiali Lou Ruijie Ma Yi Liang Xiaomei Shao Jianqiao Fang | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，3： | 0 |
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