|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation显示文摘Colorectal cancer(CRC) is one of the most common malignancies with high prevalence and low 5-year survival.CRC is a heterogeneous disease with a complex,genetic and biochemical background.It is now generally accepted that a few important intracellular signaling pathways,including Wnt/β-catenin signaling,Ras signaling,and p53 signaling are frequently dysregulated in CRC.Patients with mutant p53 gene are often resistant to current therapies,conferring poor prognosis.Tumor suppressor p53 protein is a transcription factor inducing cell cycle arrest,senescence,and apoptosis under cellular stress.Emerging evidence from laboratories and clinical trials shows that some small molecule inhibitors exert anti-cancer effect via reactivation and restoration of p53 function.In this review,we summarize the p53 function and characterize its mutations in CRC.The involvement of p53 mutations in pathogenesis of CRC and their clinical impacts will be highlighted.Moreover,we also describe the current achievements of using p53 modulators to reactivate this pathway in CRC,which may have great potential as novel anti-cancer therapy. | Xiao-Lan Li Jianbiao Zhou Zhi-Rong Chen Wee-Joo Chng | 2015 | World Journal of Gastroenterology2015，21，1： | 30 |
| 2 | Study on gob-side entry retaining in fully-mechanized longwall with top-coal caving and its application显示文摘Based on the engineering background of gob-side entry retaining in fully-mechanized longwall with top coal caving(GER-FLTC) on N2105 working face of Yuwu coal mine, by adopting the methods of theoretical analysis and numerical calculation, the control techniques of surrounding rocks in GER-FLTC working face are studied in this paper. The two main difficulties of stability of surrounding rocks at gob-side retained entry in fully-mechanized longwall working face are the stability control of top coal and control of large deformation of GER-FLTC working face. Interaction mechanical model between roofing and roadside backfilling in GER-FLTC is established and the equations for the calculation of roof-cutting resistance of roadside backfilling are derived. Results of numerical calculation show that the damage zones of top coal can be categorized into the delaminating zone of top coal above the backfilling, tensile damage zone of top coal above the retained roadway and shear damage zone of the upper rib of the solid coal. Stability control of top coal is the critical part to success of GER-FLTC. With consideration of large deformation of surrounding rocks of gob-side retained entry in fully-mechanized longwall, the support technique of‘‘roofing control and wall strengthening'' is proposed where high strength and highly prestressed anchor rods and diagonal tensile anchor cables support are used for top coal, high strength and highly prestressed yielding anchor rod support is used for solid coal and roadside prestressed load-carrying backfilling is constructed by high-water material, in order to maintain the integrity of the top coal, transfer load, high resistance yielding load-carrying of solid coal, roof-cutting of roadside backfilling and support,and to achieve GER-FLTC. Results from this study are successfully applied in engineering practice. | Su Hai Bai Jianbiao Yan Shuai Chen Yong Zhang Zizheng | 2015 | International Journal of Mining Science and Technology2015，25，3： | 12 |
| 3 | Deformation mechanism and stability control of roadway along a fault subjected to mining显示文摘It is difficult to maintain the roadway around a fault because of the fractured surroundings,complex stress environment,and large and intense deformation in the mining process.Based on a tailgate of panel S2205 in Tunliu colliery,in Shanxi province,China,we investigated the evolution of stress and displacement of rocks surrounding the roadway during the drivage and mining period using theoretical analysis,numerical simulation and field trial methods.We analyzed the deformation and failure mechanisms of the tailgate near a fault.The deformation of surrounding rock caused by unloading in the drivage period is large and asymmetric,the roadway convergence increases with activation of the fault and secondary fracture develops in the mining period.Therefore,we proposed a specific control technique of the roadway along a fault as follows:(1) High-strength yielding bolt not only supports the shallow rock to loadbearing structures,but also releases primary deformation energy by use of a pressure release device in order to achieve high resistance to the pressure retained;(2) Grouting of near-fault ribside after initial stabilization of the rock deformation is used to reinforce the broken rock,and to improve the integral load-bearing capacity of the roadway.The research results were successfully applied to a field trial. | Yan Shuai Bai Jianbiao Li Wenfeng Chen Jigang Li Lei | 2012 | International Journal of Mining Science and Technology2012，22，4： | 11 |
| 4 | Cold acclimation improves photosynthesis by regulating the ascorbate–glutathione cycle in chloroplasts of Kandelia obovata显示文摘As the most northerly mangrove species in China, Kandelia obovata may undergo extreme cold event stress. Enhancing the cold tolerance of this species is crucial to its successful afforestation. This study aimed to determine the resistance of K. obovata seedlings to low temperature stress by cold acclimation and to explain the mechanisms for alleviating cold injury. To understand these mechanisms, seedlings that were acclimatized and not acclimatized were exposed to 5℃/- 2℃(day/night)for 48 h.Results showed that low temperature stress reduced leaf photosynthesis of non-acclimatized seedlings by inducing oxidative stress and structural damage to chloroplasts. These phenomena were shown by increasing levels of malondialdehyde (MDA), O2-and H2O2, as well as decreasing enzyme activities in the ascorbate–glutathione (AsA-GSH) cycle. However, cold-acclimatized seedlings had improved photosynthetic rates and efficiency of photosystem II (PSII) under low temperature stress. Compared with non-acclimatized seedlings, leaves of coldacclimatized seedlings under low temperature stress for 48 h exhibited higher anti-oxidative enzyme activities, lower levels of O2^- and H2O2, less damage to chloroplast structure, and removed 33.7% of MDA at low temperature stress for 48 h. The data indicate that cold acclimation enhances photosynthetic capacity by effectively regulating activation in the PSII electron transport and the AsA–GSH cycle to scavenge excess ROS in chloroplasts, while the latter is more important. | Weicheng Liu Chunfang Zheng Jinong Chen Jianbiao Qiu Zhixing Huang Qi Wang Yong Ye | 2019 | Journal of Forestry Research2019，30，3： | 11 |
| 5 | Characteristics of stress distribution in floor strata and control of roadway stability under coal pillars显示文摘给在煤支柱下面在车道支持遇到的困难,我们在车道稳定性上学习了压力分发和他们的效果的特征,用理论分析和数字模拟。当水平应力减少时,结果证明在一个煤支柱下面,在一个地板阶层的垂直应力增加。我们断定垂直、水平的应力之间的增加的差别是为包围岩石的变丑和在煤支柱下面的车道的失败的一个重要原因。基于这,我们在一个煤支柱下面建议一条车道的包围岩石的控制技术例如高力量和高对的门栓支持,打电报加强支持,单个水力由包围岩石的 grouting 与横梁支持和加强支撑,它成功地在一个煤支柱下面在一条车道的一个稳定性控制工程被使用了。 | Tongqiang Xiao Bai Jianbiao Xu Lei Zhang Xuebin | 2011 | Mining Science and Technology2011，21，2： | 9 |
| 6 | Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia显示文摘Accumulating evidence support the notion that acute myeloid leukemia(AML) is organized in a hierarchical system, originating from a special proportion of leukemia stem cells(LSC). Similar to their normal counterpart, hematopoietic stem cells(HSC), LSC possess selfrenewal capacity and are responsible for the continued growth and proliferation of the bulk of leukemia cells in the blood and bone marrow. It is believed that LSC are also the root cause for the treatment failure and relapse of AML because LSC are often resistant to chemotherapy. In the past decade, we have made significant advancement in identification and understanding the molecular biology of LSC, but it remains a daunting task to specifically targeting LSC, while sparing normalHSC. In this review, we will first provide a historical overview of the discovery of LSC, followed by a summary of identification and separation of LSC by either cell surface markers or functional assays. Next, the review will focus on the current, various strategies for eradicating LSC. Finally, we will highlight future directions and challenges ahead of our ultimate goal for the cure of AML by targeting LSC. | Jianbiao Zhou Wee-Joo Chng | 2014 | World Journal of Stem Cells2014，6，4： | 9 |
| 7 | Failure mechanism and stability control technology of rock surrounding a roadway in complex stress conditions显示文摘To solve the problem of supporting three downhill coal structures in the Yongan Coal Mine of Shanxi Jincheng, we studied the regular development of stress and plastic zones and characteristics of deformation of rock surrounding roadway groups after a period of roadway driving, mining one side as well as mining both sides, we used FLAC 3D for our numerical and theoretical analyses. Field test were carried out, where we revealed the deformation mechanism of roadways and its coal pillars in complex stress conditions. We proposed a roadway stability control technology using backwall grouting with high-water rapid hardening material and combined support with bolt and cable anchoring after mining both sides. Our field practices showed that deformation of rock surrounding roadways can be controlled with this technology. | Yu Yang Bai Jianbiao Chen Ke Wang Xiangyu Xiao Tongqiang Chen Yong | 2011 | Mining Science and Technology2011，21，3： | 8 |
| 8 | Mechanisms on inhibition of photosynthesis in Kandelia obovata due to extreme cold events under climate change显示文摘Introduction:Mangroves that grow at the latitudinal extremes of their distribution are susceptible to extreme cold events.Successive enhancement of low temperature stress(seLTS)is a typical characteristic of extreme cold events.Low temperature stress can inhibit mangrove photosynthesis,which often inhibits the growth and development of mangroves.However,the possible reasons for impairment to photosynthesis of mangroves due to extreme cold events remain unclear.Methods:Kandelia obovata seedlings in a growth chamber were exposed to 5℃/−2℃(day/night)for 36 h(−2℃ for 16 h)with 12 h light per day at 600μmol m^(−2) s^(−1) photosynthetic photon flux density(PPFD)(a low temperature stress,aLTS),then the plants were transferred to the control condition(15℃/10℃(day/night)and allowed to recover for 5 days(R1).The other seedlings were subjected to low temperature treatment with a day/night temperature of 5℃/−1℃ in a growth chamber for 24 h.Then these plants were transferred to 5℃/−2℃(day/night)under the same light and climate conditions for 36 h(two low temperature stresses,tLTS).Following the successive enhancement of low temperature treatment,these plants were returned to 15℃/10℃(day/night)for another 5-day recovery period(R2).Results:Results showed that aLTS treatment significantly reduced leaf net photosynthetic rate(P_(n))and stomatal conductance(G_(s)),while increased intercellular CO_(2) concentration(C_(i)).Photosynthetic activity of leaves quickly recovered after the plants were returned to control temperature for 5 days(R1).However,decreases in leaf Pn were more obvious under tLTS treatment than those under aLTS treatment.This reduced Pn might be attributed to stomatal and non-stomatal limitations.Moreover,non-stomatal limitation played a major role in reducing Pn during tLTS treatment,as proven by reduced ribulose 1,5-biphosphate carboxylase(RuBPCase)activity.This limitation also enhanced lipid peroxidation in chloroplasts,decreased sucrosemetabolizing enzymes and ratios of both chlorophyll a/chlorophyll b(Chl a/b)and chlorophyll/carotenoids(Chl/Car),and increased protease senescence.Damages of tLTS treatment to photosynthesis were insufficiently alleviated even after the plants were returned to control temperature for 5 days(R2).Conclusions:Successive enhancement of low temperature depressed successful recovery of leaf photosynthesis of K.obovata seedlings mainly by impairing pigment synthesis,antioxidant metabolism,and sucrose translocation,as well as accelerating senescence of endopeptidase.Furthermore,our results suggest that decreases in sucrose content in leaves might also account for increases in reactive oxygen species(ROS)in chloroplasts. | Chunfang Zheng Jianwu Tang Jinong Chen Weicheng Liu Jianbiao Qiu Xin Peng Yong Ye | 2016 | Ecological Processes2016，5，1： | 6 |
| 9 | Bearing characteristics of coal pillars based on modified limit equilibrium theory显示文摘There are two states for the coal-mass on the goaf-side which is in stress equilibrium: the state of limit equilibrium(the bearing stress in the coal-mass equals its ultimate bearing stress) and the state of nonultimate equilibrium(the bearing stress in the coal-mass is less than its ultimate bearing stress). To analyze the bearing characteristics of a coal pillar in the state of limit equilibrium and guide the design of pillar width, we established a mechanical analytical model of the non-ultimate equilibrium zone in the coal-mass on the goaf-side combined with the limit equilibrium theory as well as adopting the methods of theory analysis and mechanical analysis based on the assumption of a state of non-ultimate equilibrium. The width correction coefficient of the limit equilibrium zone has been given. The influence of mining depth, stress concentration coefficient of the surrounding rock, the non-limit strength of the coal-mass and stability of the coal rock interface has been studied. On this basis, we have confirmed that when the width of a longwall mining face roadway protection coal pillar is between 11.6 m and 13.16 m in No. 4 coal seam of Xinrui coal mine in Lvliang in Shanxi province the elastic core region in the coal pillar can be assured and the roadway will be located in the area of lower stress which is outside the peak stress. So the revised width of the limit equilibrium zone is more practical. | Wang Xiangyu Bai Jianbiao Wang Ruofan Sheng Wenlong | 2015 | International Journal of Mining Science and Technology2015，25，6： | 6 |
| 10 | Control mechanism and technique of floor heave with reinforcing solid coal side and floor corner in gob-side coal entry retaining显示文摘Floor heave is the most common convergence in gob-side entry retaining.The paper analyzes the form,process and characteristics of gob-side entry retaining with the comprehensive methods of theoretical analysis,numerical simulation and the field trial.Research results present that bending and folding floor heave is the main factor in the stage of the first panel mining;squeezing and fluidity floor heave plays a great role in the stable stage of gob-side entry retaining;the combination of the former two factors affects mainly the stage of the second mining ahead;abutment pressure is a fundamental contribution to the serious floor heave of gob-side entry retaining,and sides corners of solid coal body are key part in the case of floor heave controlling of gob-side entry retaining.Floor heave of gob-side entry retaining can be significantly controlled by reinforcing sides and corners of solid coal body,and influence rules on the floor heave of gob side entry retaining of sides supporting strength and the bottom bolt orientation in solid coal side are obtained.Research results have been successfully applied in gob-side entry retaining of G20-F23070 face haulage roadway in #2 coal mine of Pingmei Group,and the field observation shows that the proposed technique is an effective way in controlling the floor heave of gob-side entry retaining. | Chen Yong Bai Jianbiao Yan Shuai Xu Ying Wang Xiangyu Ma Shuqi | 2012 | International Journal of Mining Science and Technology2012，22，6： | 6 |
| 11 | Magnetic performance and corrosion resistance of electroless plating CoWP film显示文摘The CoWP film with good magnetic performance and corrosion resistance was electrolessly plated from alkaline solution. The technical parameters of the electroless plating system were optimized. When the pH value of electroless plating solution was 11.0 and the reducing agent (NaH2PO2) content was 0.4 mol L 1, the target chemical reactions proceeded in the electroless plating solution smoothly with negligible interference and side effects. CoWP film prepared under optimal deposition condition contained more hexagonal close-packed (hcp) cobalt (ε-Co) of [110] and crystallographic orientation of Co [002]. VSM analysis reveals that the saturation magnetization of the CoWP film is 100~220 Am2 kg 1 and coercivity is (2.87~4.38)×104 A·cm 1. The corrosion behavior of CoWP film in 3.5% NaCl aqueous solution was studied by electrochemical experiments. The results prove that the corrosion resistance of the CoWP film deposited under the optimal depo-sition condition exhibites relatively lower corrosion current of (3.054~3.162)×10 6 A·cm 2. The surface morphology analysis indicates that the film is smooth and composed of regular-shaped crystallites. | Jiang, Li Pan, Shanshan Lu, Jianbiao Ke, Xin He, Wenhao Yu, Yundan Wei, Guoying Ge, Hongliang | 2012 | Rare Metals2012，31，3： | 6 |
| 12 | Behavior Measurement Model Based on Prediction and Control of Trusted Network显示文摘In order to construct the trusted network and realize the trust of network behavior,a new multi-dimensional behavior measurement model based on prediction and control is presented.By using behavior predictive equation,individual similarity function,group similarity function,direct trust assessment function,and generalized predictive control,this model can guarantee the trust of an end user and users in its network.Compared with traditional measurement model,the model considers different characteristics of various networks.The trusted measurement policies established according to different network environments have better adaptability.By constructing trusted group,the threats to trusted group will be reduced greatly.Utilizing trusted group to restrict individuals in network can ensure the fault tolerance of trustworthiness of trusted individuals and group.The simulation shows that this scheme can support behavior measurement more efficiently than traditional ones and the model resists viruses and Trojans more efficiently than older ones. | Gong Bei Zhang Jianbiao Shen Changxiang Zhang Xing | 2012 | China Communications2012，9，5： | 5 |
| 13 | Tomography of the dynamic stress coefficient for stress wave prediction in sedimentary rock layer under the mining additional stress显示文摘In this study,the tomography of dynamic stress coefficient(TDSC)was established based on a mechanical model of stress wave propagation in bedding planes and a mathematical model of the stress wave attenuation in rock masses.The reliability of the TDSC was verified by a linear bedding plane model and field monitoring.Generally,the TDSC in the dynamic stress propagation of bedding planes increases with the following conditions:(1)the increase of the normal stiffness of the bedding plane,(2)the increase of the incident angle of the stress wave,(3)the decrease of the incident frequency of the stress wave,or(4)the growth of three ratios(the ratios of rock densities,elastic moduli,and the Poisson’s ratios)of rocks on either side of bedding planes.The additional stress weakens TDSC linearly and slowly during the stress wave propagation in bedding planes,and the weakening effect increases with the growth of the three ratios.Besides,the TDSC decreases exponentially in the rock mass as propagation distance increases.In a field case,the TDSC decreases significantly as vertical and horizontal distances increase and its wave range increases as vertical distance increases in the sedimentary rock layers. | Wenlong Shen Guocang Shi Yungang Wang Jianbiao Bai Ruifeng Zhang Xiangyu Wang | 2021 | International Journal of Mining Science and Technology2021，31，4： | 5 |
| 14 | Stability control of gob-side entry retained under the gob with close distance coal seams显示文摘In multi-seam mining,the interlayer rock strata between the upper coal seam(UCS)and the lower coal seam(LCS)appear damage and strength weakening after mining the UCS.Ground stability control of the gob-side entry retaining(GER)under the gob with close distance coal seams(CDCS)is faced with difficulties due to little attention to GER under this condition.This paper focuses on surrounding rock stability control and technical parameters design for GER under the gob with CDCS.The floor rock strata damage characteristics after mining the UCS is first evaluated and the damage factor of the interlayer rock strata below the UCS is also determined.Then,a structural mechanics model of GER surrounding rock is set up to obtain the main design parameters of the side-roadway backfill body(SBB)including the maximum and minimum SBB width calculation formula.The optimal SBB width and the water-to-cement ratio of high water quick-setting material(HWQM)to construct the SBB are determined as 1.2 m and 1.5:1.0,respectively.Finally,engineering trial tests of GER are successfully carried out at#5210 track transportation roadway of Xingwu Colliery.Research results can guide GER design under similar mining and geological conditions. | Zizheng Zhang Min Deng Jianbiao Bai Shuai Yan Xianyang Yu | 2021 | International Journal of Mining Science and Technology2021，31，2： | 5 |
| 15 | Fixed-length roof cutting with vertical hydraulic fracture based on the stress shadow effect:A case study显示文摘Pre-driven longwall retracement roadway(PLRR)is commonly used in large mine shaft.The support crushing disasters occur frequently during the retracement,and roof management is necessary.Taking the 31107 panel as research background,the roof breaking structure of PLRR is analyzed.It is concluded that the roof cutting with vertical hydraulic fracture(HF)at a specified position,that is,fixed-length roof cutting,can reduce support load and keep immediate roof intact.The extended finite element method(XFEM)is applied to simulate hydraulic fracturing.The results show that both the axial and transverse hydraulic fracturing cannot effectively create vertical HFs.Therefore,a novel construction method of vertical HF based on the stress shadow effect(SSE)is proposed.The stress reversal region and HF orientation caused by the prefabricated hydraulic fracture(PF)are verified in simulation.The sub-vertical HFs are obtained between two PFs,the vertical extension range of which is much larger than that of directional hydraulic fracturing.The new construction method was used to determine the field plan for fixed-length roof cutting.The roof formed a stable suspended structure and deformation of the main PLRR was improved after hydraulic fracturing. | Feiteng Zhang Xiangyu Wang Jianbiao Bai Wenda Wu Bowen Wu Guanghui Wang | 2022 | International Journal of Mining Science and Technology2022，32，2： | 4 |
| 16 | Recovery of photosynthesis,sucrose metabolism,and proteolytic enzymes in Kandelia obovata from rare cold events in the northernmost mangrove,China显示文摘Introduction:Understanding how mangroves respond to rare cold events has implications for both restoration and conservation under climate change scenarios.This study investigated the responses of photosynthesis and activities of key enzymes involving carbon and nitrogen metabolism at different ages of Kandelia obovata to a rare cold event in the winter of 2010.Methods:This study took place on Ximen Island,Zhejiang Province,China.We measured the physiological recovery of 2-3-,5-6-,9-10-and 54-55-year-old K.obovata trees after freezing injury in February and March in 2011 and 2012,respectively.Results:Chilling injury index and electrolyte leakage of K.obovata increased with increasing tree age in the winter of 2010,and electrolyte leakage in K.obovata at different ages in the winter of 2010 was far higher than that in the winter of 2011.The rare cold events significantly changed the recoveries of the leaf net photosynthetic rate(Pn)and stomatal conductance(Gs);ratios of chlorophyll a/chlorophyll b(Chl a/Chl b);contents of total soluble sugar(TSS),sucrose,free amino acid(FAA),and soluble protein;and activities of sucrose phosphate synthase(SPS),endopeptidase,and carboxypeptidase in K.obovata at different ages.These effects were mainly due to changes in the physiological mechanism in the 2-year-old trees.A clear decrease in Pn of the 2-year-old trees was observed in February 2011,as exemplified by reductions in ratios of Chl a/Chl b and chlorophyll/carotenoid(Chl/Car),as well as inhibition of the levels of TSS and FAA(osmotic substances).During recovery in 2011 and 2012,the activities of SPS and sucrose synthase(SS)were responsible for sucrose synthesis after the rare cold events in 2011,but only SPS activity was one of the main factors contributing to the metabolism of stachyose to sucrose without cold damage in 2012.Carboxypeptidase played a more important role than endopeptidase during protein hydrolysis after the rare cold events.Conclusions:The results suggest that the recovery of photosynthetic capacity in K.obovata was changed after a rare cold event,which is associated with pigment components and activities of SS,SPS,and carboxypeptidase,especially the seedlings. | Chunfang Zheng Yong Ye Weicheng Liu Jianwu Tang Chengnian Zhang Jianbiao Qiu Jinong Chen | 2016 | Ecological Processes2016，5，1： | 4 |
| 17 | Test and application of hydraulic expansion bolts in a roadway under goaf with ultra-close separation显示文摘The roof of a roadway under goaf with ultra-close separation consists of thin rock strata and rocks caving in upper goaf. Influenced by the mining of the upper coal seam, the roof is loose and broken, and its integrity is poor. Resin anchored bolts cannot provide an effective anchoring force in such roof conditions. By conducting free expansion tests and field pull-out tests on a hydraulic expansion bolt, this study has analyzed the influencing factors and laws of radial expansion and anchoring force changes in the rod body.This has revealed the anchoring mechanism of such bolts, and has obtained reasonable water injection pressures and suitable drilling diameters(which are 20–25 MPa and 32–35 mm respectively) for the hydraulic expansion bolt(u28 mm) used in these tests. Based on pull-out tests at different interlayer spacing, the applicability of hydraulic expansion bolts had been verified for controlling the roof of roadways under goaf with ultra-close distance. Combined with the deformation and failure characteristics of the test roadway roof, this paper proposes a united roof-control technology based on the use of hydraulic expansion bolts and advancing intubation for the roof. Engineering practice indicated that the roof of the test roadway did not generate leaking and caving phenomenon, and the amount of roof deformation was controlled to within 150 mm. Maintenance of the roadway roof has been improved significantly, which ensures safe mining in coal seams with ultra-close separation. | Wang Xiangyu Bai Jianbiao Guo Guanlong Yu Yang | 2014 | International Journal of Mining Science and Technology2014，24，6： | 4 |
| 18 | High-resistance controlled yielding supporting technique in deep-well oil shale roadways显示文摘In order to avoid the deep-well oil shale roadway being deformed, damaged, or difficult to maintain after excavating and supporting in Haishiwan coal mine, this paper has analyzed the characteristics of the deformed roadway and revealed its failure mechanism by taking comprehensively the methods of field geological investigation, displacement monitoring of surrounding rock, rock properties and hydration properties experiments and field application tests. Based on this work, the high-resistance controlled yielding supporting principle is proposed, which is: to ‘‘resist'' by high pre-tightening force and high stiffness in the early stage, to ‘‘yield'' by making use of the controlled deformation of a yielding tube in the middle stage, and to ‘‘fix'' by applying total-section Gunite in the later stage. A high-resistance controlled yielding supporting technique of ‘‘high pre-tightening force yielding anchor bolt + small-bore pre-tightening force anchor cable + rebar ladder beam + rhombic metal mesh + lagging gunite'' has been established, and industrial on site testing implemented. The practical results show that the high-resistance controlled yielding supporting technique can effectively control the large deformation and long-time rheology of deep-well oil shale roadways and can provide beneficial references for the maintenance of other con-generic roadways. | Yu Yang Bai Jianbiao Wang Xiangyu Wang Junde Xue Shizhi Xu Ke | 2014 | International Journal of Mining Science and Technology2014，24，2： | 3 |
| 19 | Novel mechanism of drug resistance to proteasome inhibitors in multiple myeloma显示文摘Multiple myeloma(MM) is a cancer caused by uncontrolled proliferation of antibody-secreting plasma cells in bone marrow, which represents the second most common hematological malignancy. MM is a highly heterogeneous disease and can be classified into a spectrum of subgroups based on their molecular and cytogenetic abnormalities. In the past decade, novel therapies, especially, the first-in-class proteasome inhibitor bortezomib, have been revolutionary for the treatment of MM patients. Despite these remarkable achievements, myeloma remains incurable with a high frequency of patients suffering from a relapse, due to drug resistance. Mutation in the proteasome β5-subunit(PSMB5) was found in a bortezomib-resistant cell line generated via long-term coculture with increasing concentrations of bortezomib in 2008, but their actual implication in drug resistance in the clinic has not been reported until recently. A recent study discovered four resistance-inducing PSMB5 mutations from a relapsed MM patient receiving prolonged bortezomib treatment. Analysis of the dynamic clonal evolution revealed that two subclones existed at the onset of disease, while the other two subclones were induced. Protein structural modeling and functional assays demonstrated that all four mutations impaired the binding of bortezomib to the 20 S proteasome, conferring different degrees of resistance. The authors further demonstrated two potential approaches to overcome drug resistance by using combination therapy for targeting proteolysis machinery independent of the 20 S proteasome. | Jianbiao Zhou Wee-Joo Chng | 2019 | World Journal of Clinical Oncology2019，10，9： | 3 |
| 20 | 基于DMAIC与仿真的地铁乘坐流程改进显示文摘为缩短乘坐地铁等待时间、减少地铁站拥挤程度,运用六西格玛DMAIC改善方法,通过定义、测量、分析和改进指导改善流程,对地铁运营现状调研分析与改进。重点构建了控制图与运行图,分析了造成长时间等待的内部原因与外部原因,并结合工业工程方法给出了购票流程优化、目视化管理和少人化柔性服务综合性改善方案,并运用仿真模拟软件对改善效果进行了验证。结果表明,改善方案在缩短等待时间、提高服务稳定性、提高人员利用率与均衡人员工作负荷4个方面将有近21%的提升。 | 王晨霖 鲁建厦 ANZAI Kenji 李嘉丰 PAN Jianbiao | 2017 | 工业工程2017，20，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员