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| 1 | Challenges of Big Data analysis显示文摘Big Data bring new opportunities to modern society and challenges to data scientists. On the one hand,Big Data hold great promises for discovering subtle population paterns and heterogeneities that are not possible with small-scale data. On the other hand, the massive sample size and high dimensionality of Big Data introduce unique computational and statistical challenges, including scalability and storage botleneck, noise accumulation, spurious correlation, incidental endogeneity and measurement errors.hese challenges are distinguished and require new computational and statistical paradigm. his paper gives overviews on the salient features of Big Data and how these features impact on paradigm change on statistical and computational methods as well as computing architectures. We also provide various new perspectives on the Big Data analysis and computation. In particular, we emphasize on the viability of the sparsest solution in high-conidence set and point out that exogenous assumptions in most statistical methods for Big Data cannot be validated due to incidental endogeneity. hey can lead to wrong statistical inferences and consequently wrong scientiic conclusions. | Jianqing Fan Fang Han Han Liu | 2014 | National Science Review2014，1，2： | 57 |
| 2 | Structural pattern of eastern Himalayan syntaxis in Namjagbarwa and its formation process显示文摘The structural pattern of the eastern Himalayan syntaxis in Namjagbarwa consists of two series of structures with different styles. One series compiles the earlier ductile contractional and lateral-slip deformation system, formed by nearly north-south shortening within the syntaxis, left-lateral and right-lateral slipping along its western and eastern boundaries respectively. They were possibly produced by the indentation of the Indian continent into Asian continent after India-Asia collision. The peak deformation-metamorphic ages in these structures are 62-60 Ma, ~23 Ma and ~13 Ma. The other series is composed of ductile-brittle normal faults distributing concentrically and dipping toward the outsides of Namjagbarwa Peak. They were probably the collapse structures caused by rapid uplift in a later time and the beginning ages for the normal faulting are about 7.3-6.3 Ma. | ZHANG Jinjiang, Jl Jianqing, ZHONG Dalai, DING Lin & HE Shundong1. Department of Geology, Peking University, Beijing 100871, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Correspondence should be addressed to Zhang Jinjiang (email: zhjj@pku.edu.cn) | 2004 | Science China Earth Sciences2004，47，2： | 34 |
| 3 | Early Paleozoic granite in Nujiang River of northwest Yunnan in southwestern China and its tectonic implications显示文摘沿着在西方的云南的中国缅甸边阶的 Nujiang 区域收到了很多注意并且被认为是西藏的高原的向东南的逃跑的重要隧道。这条隧道被红 River-Ailao 山左文字的 strick 滑倒差错在这条隧道以内在西方在东方和英雄传奇 Gaoligong 正确文字的 strick 滑倒差错毗邻,它仍然不对贡尚·布洛克哪个构造单位合适清楚。尽管一些研究人员建议它是 Sundaland 岩层的北方结束,它的构造定义是相当模糊的。这篇论文报导我们 U-Pb 同位素的 geochronological 在贡尚·布洛克以内在 Gudang 片麻岩的花岗石上学习的新锆石。这研究在理解起源和西北的云南的构造环境起一个重要作用。 | SONG ShuGuang JI JianQing WEI ChunJing SU Li ZHENG YaDong SONG Biao ZHANG LiFei | 2007 | Chinese Science Bulletin2007，52，17： | 31 |
| 4 | Non-canonical regulation of SPL transcription factors by a human OTUBl-like deubiquitinase defines a new plant type rice associated with higher grain yield显示文摘完成增加的谷物生产率长是引起节目的谷物的制服的焦点。ideotype 途径被用来在国际瑞斯研究院并且在中国改进米饭收益潜力。然而,在米饭的收益相关的特点的基因基础仍然保持不清楚。这里,我们显示出那一个主要量的特点地点, qNPT1,通过建筑学由更少 tillers 描绘了的一种新植物类型(NPT ) 的决心的行为,更坚定的灰煤杆和更大的圆锥花序,并且它与相同编码 deubiquitinating 酶到人的 OTUB1。OsOTUB1 的 Downregulation 提高 meristematic 活动,导致在谷物产量的减少的 tiller 数字,增加的谷物数字,提高的谷物重量和米饭的作为结果的增加。不同于人的 OTUB1, OsOTUB1 能劈开连接 K48 、连接 K63 的 polyubiquitin。OsOTUB1 与 E2 结合 ubiquitin 蛋白质 OsUBC13 和 squamosa 倡导者绑定交往像蛋白质的抄写因素 OsSPL14。OsOTUB1 和 OsSPL14 分享普通目标基因,和他们的物理相互作用限制 OsSPL14 的连接 K63 的 ubiquitination (K63Ub ) ,它接着支持 OsSPL14 的 K48Ub 依赖的 proteasomal 降级。相反地, OsOTUB1 的 loss-of-function 与 OsSPL14 的高水平的累积被相关,导致 NPT 建筑学。我们也证明 high-yielding npt1 和 dep1-1 等位基因节节上升为增加在当前是可完成的的上面的米饭收益潜力提供新策略。 | Shuansuo Wang Kun Wu Qian Qian Qian Liu Qi Li Yajun Pan Yafeng Ye Xueying Liu Jing Wang Jianqing Zhang Shan Li Yuejin Wu Xiangdong Fu | 2017 | Cell Research2017，27，9： | 33 |
| 5 | Anti-corrosion performance of waterborne Zn-rich coating with modified silicon-based vehicle and lamellar Zn (Al) pigments | Liuyan Zhang Aibin Ma Jinghua Jiang Dan Song Jianqing Chen Donghui Yang | 2012 | Progress in Natural Science:Materials International2012，22，4： | 26 |
| 6 | Occurrence of perfluoroalkyl substances in matched human serum,urine,hair and nail显示文摘The purpose of this study was to determine perfluoroalkyl substances(PFASs) in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHx A, PFOA, PFNA, PFDA, PFUn DA, PFDo A, PFHx S and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24 ng/mL, 13.96 ng/L, 0.58 ng/g and 0.63 ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling. | Yuxin Wang Yuxin Zhong Jingguang Li Jianqing Zhang Bing Lyu Yunfeng Zhao Yongning Wu | 2018 | Journal of Environmental Sciences2018，30，5： | 17 |
| 7 | ^(40)Ar/^(39)Ar isochron ages of lawsonite blueschists from Jiuquan in the northern Qilian Mountain,NW China,and their tectonic implications显示文摘Using laser 40Ar/39Ar dating method,we have gotten the metamorphic ages of lawsonite blueschist and epidote blueschist from Jiuquan,northern Qilian Mountain,NW China.The high quality laser 40Ar/39Ar dating of glaucophane from lawsonite blueschist gives an isochron age of 413±5 Ma.The isochron age obtained from phengite in epidote blueschist is 415±7 Ma.These data,combining with peak metamorphic P-T conditions and regional geological setting,allow us to infer that the lower limit of the ages of the prograde subduction metamorphism from lawsonite blueschist facies to epidote blueschist facies occurred at ca.413-415 Ma,which also suggests that the formation of lawsonite blueschist in the northern Qilian Mountain maybe resulted from the corner flow in the cold subduction zone.This study shows that the final closing time of the northern Qilian remnant oceanic basin is about 413-415 Ma,which also represents the convergent age between the North China Craton and the Qaidam block. | LIN YiHui ZHANG LiFei JI JianQing WANG QianJie SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，19： | 15 |
| 8 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 9 | Revealing of the ultrafast third-order nonlinear optical response and enabled photonic application in two-dimensional tin sulfide显示文摘Black phosphorus(BP), a typical mono-elemental and two-dimensional(2D) material, has gathered significant attention owing to its distinct optoelectronic properties and promising applications, despite its main obstacle of long-term stability. Consequently, BP-analog materials with long-term chemical stability show additional potential. In this contribution, tin sulfide(SnS), a novel two-elemental and 2D structural BP-analog monochalcogenide, has been demonstrated to show enhanced stability under ambient conditions. The broadband nonlinear optical properties and carrier dynamics have been systematically investigated via Z-scan and transient absorption approaches. The excellent nonlinear absorption coefficient of 50.5 × 10^-3 cm∕GW, 1 order of magnitude larger than that of BP, endows the promising application of SnS in ultrafast laser generation. Two different decay times of τ1~873 fs and τ2~96.9 ps allow the alteration between pure Q switching and continuous-wave(CW) mode locking in an identical laser resonator. Both mode-locked and Q-switched operations have been experimentally demonstrated using an SnS saturable absorber at the telecommunication window. Femtosecond laser pulses with tunable wavelength and high stability are easily obtained, suggesting the promising potential of SnS as an efficient optical modulator for ultrafast photonics. This primary investigation may be considered an important step towards stable and high-performance BP-analog material-based photonic devices. | Zhongjian Xie Feng Zhang Zhiming Liang Taojian Fan Zhongjun Li Xiantao Jiang Hong Chen Jianqing Li Han Zhang | 2019 | Photonics Research2019，7，5： | 13 |
| 10 | From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease(HFMD)显示文摘Hand,foot,and mouth disease(HFMD)recently emerged as a global public threat.The licensure of inactivated enterovirus A71(EV-A71)vaccine was the first step in using a vaccine to control HFMD.New challenges arise from changes in the pathogen spectrum while vaccines directed against other common serotypes are in the preclinical stage.The mission of a broad-spectrum prevention strategy clearly favors multivalent vaccines.The development of multivalent vaccines was attempted via the simple combination of potent monovalent vaccines or the construction of chimeric vaccines comprised of epitopes derived from different virus serotypes.The present review summarizes recent advances in HFMD vaccine development and discusses the next steps toward a safe and effective HFMD vaccine that is capable of establishing a crossprotective antibody response. | Xiangchuan He Miaomiao Zhang Chen Zhao Peiyong Zheng Xiaoyan Zhang Jianqing Xu | 2021 | Virologica Sinica2021，36，2： | 13 |
| 11 | The western boundary of extrusion blocks in the southeastern Tibetan Plateau显示文摘The model about block extrusion related to collision between Eurasia and India which is proposed by Tapponnier et al. has not been accepted so far in the field. Based on kinematics and chronology, the Gailigong dextral strike-slip fault in west Yunnan and Nabang dextral strike-slip fault which is the part of Mogok belt are the western boundary of extrusion blocks, as the eastern boundary Red River-Ailaoshan left-lateral fault. And more studies show that as the important way for absorbing the convergence between two continents, the age of blocks’ multistage extrusion is about 23 and 13 Ma. | JI Jianqing ZHONG Dalai SANG Haiqing ZHANG Liansheng | 2000 | Chinese Science Bulletin2000，45，10： | 11 |
| 12 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 13 | Changes in Extreme Maximum Temperature Events and Population Exposure in China under Global Warming Scenarios of 1.5 and 2.0°C: Analysis Using the Regional Climate Model COSMO-CLM显示文摘We used daily maximum temperature data(1986–2100) from the COSMO-CLM(COnsortium for Small-scale MOdeling in CLimate Mode) regional climate model and the population statistics for China in 2010 to determine the frequency, intensity, coverage, and population exposure of extreme maximum temperature events(EMTEs) with the intensity–area–duration method. Between 1986 and 2005(reference period), the frequency, intensity, and coverage of EMTEs are 1330–1680 times yr^(–1), 31.4–33.3°C, and 1.76–3.88 million km^2, respectively. The center of the most severe EMTEs is located in central China and 179.5–392.8 million people are exposed to EMTEs annually. Relative to 1986–2005, the frequency, intensity, and coverage of EMTEs increase by 1.13–6.84, 0.32–1.50, and15.98%–30.68%, respectively, under 1.5°C warming; under 2.0°C warming, the increases are 1.73–12.48, 0.64–2.76,and 31.96%–50.00%, respectively. It is possible that both the intensity and coverage of future EMTEs could exceed the most severe EMTEs currently observed. Two new centers of EMTEs are projected to develop under 1.5°C warming, one in North China and the other in Southwest China. Under 2.0°C warming, a fourth EMTE center is projected to develop in Northwest China. Under 1.5 and 2.0°C warming, population exposure is projected to increase by23.2%–39.2% and 26.6%–48%, respectively. From a regional perspective, population exposure is expected to increase most rapidly in Southwest China. A greater proportion of the population in North, Northeast, and Northwest China will be exposed to EMTEs under 2.0°C warming. The results show that a warming world will lead to increases in the intensity, frequency, and coverage of EMTEs. Warming of 2.0°C will lead to both more severe EMTEs and the exposure of more people to EMTEs. Given the probability of the increased occurrence of more severe EMTEs than in the past, it is vitally important to China that the global temperature increase is limited within 1.5°C. | Mingjin ZHAN Xiucang LI Hemin SUN Jianqing ZHAI Tong JIANG Yanjun WANG | 2018 | Journal of Meteorological Research2018，32，1： | 11 |
| 14 | Identification of potential cross-protective epitope between a new type of coronavirus(2019-nCoV)and severe acute respiratory syndrome virus显示文摘Recently,a new type of unknown virus causing severe acute res-piratory infection was reported in Wuhan city,Hubei province,China(WHO,2020b).Infection of this virus was first reported in December 2019,and origin of the virus was traced back to a large seafood/wide animal market in Wuhan city.The serious clinical symptoms of the viral infection,including fever,dry cough,dys-pnea,and pneumonia,may result in progressive respiratory failure and even death.Moreover,the quick spread of the virus has caused an epidemic in China,as well as infection cases worldwide.The whole-genome sequence of Wuhan new virus(WH-Human_.1)was first released on January 10,2020(Zhang,2020),followed by additional ones released in Global Initiative on Sharing All Influ-enza Data(GISAID)(Shu and McCauley,2017).Later,this new virus was determined and announced as a new type of coronavirus(CoV;2019-nCoV)by the World Health Organization(WHO,2020a). | Tianyi Qiu Tiantian Mao Yuan Wang Mengdi Zhou Jingxuan Qiu Jianwei Wang Jianqing Xu Zhiwei Cao | 2020 | Journal of Genetics and Genomics2020，47，2： | 11 |
| 15 | Thermodynamic conditions of framework grain dissolution of clastic rocks and its application in Kela 2 gas field显示文摘Feldspar and clastic debris are the most important constituent framework grains of sedimentary clastic rocks and their chemical dissolution plays an essential role in the formation and evolution of the secondary pore in the reservoir rocks. On the basis of thermodynamic phase equilibrium, this study investigates the chemical equilibrium relationships between fluid and various plagioclase and K-feldspar in diagenesis of the sediments, particularly, the impact of temperature and fluid compositions (pH, activity of K+, Na+, Ca2+ and so on) on precipitation and dissolution equilibria of feldspars. Feldspar is extremely easily dissolved in the acid pore water with a low salinity when temperature decreases. The dissolution of anorthite end-member of plagioclase is related to the Ca content of the mineral and the fluid, higher Ca either in the mineral or in the fluid, easier dissolution of the feldspar. Moreover, the dissolution of albite end-member of plagioclase is related to Na of both the mineral and fluid, lower Na out of both the mineral and fluid, easier dissolution of the mineral. Similarly, lower-K fluid is more powerful to dissolve K-feldspar than the higher. The anorthite component of plagioclase is most easily dissolved in ground water-rock system, the albite is the secondary, and K-feldspar is the most stable. Selective dissolution of plagioclase occurs in diagenesis because of the plagioclase solid solution that is mainly composed of albite and anorthite end-members, Ca-rich part of which is preferentially dissolved by the pore water, in contrast to the Na-rich parts. Based on investigation of reservoir quality, secondary pore, dissolution structures of feldspar, clay minerals and ground water chemistry of the Kela 2 gas field of Kuqa Depression in the Tarim basin of Western China, we discovered that the secondary pore is very well developed in the highest quality section of the reservoir, and the plagioclase of which was obviously selectively dissolved, in contrast to the overgrowth of K-feldspar. Chemistry of the ground water out of the highest quality section of the reservoir is consistent with the complete dissolution field of anorthite, partial dissolution field of albite component of plagioclase, and the precipitation of K-feldspar on the temperature-logK phase equilibrium diagram drawn from this study. The thermodynamic modeling calculation gave us an insight into formation of the secondary pore within the reservoir, and the dissolution of plagioclase an important cause of the secondary pore. It is assumed that the solvent to dissolve the plagioclase frame grains originated from the origin-enriched compacted fluid acids out of the mudstone buried beneath the top of geopressured zones in the Kuqa Depression. | LAI Xingyun, YU Bingsong, CHEN Junyuan, CHEN Xiaolin, LIU Jianqing, MEI Mingxiang, JING Weiguang & CHENG Suhua School of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China Key Laboratory of Lithospheric Tectonics, Deep-level Process and Exploration of Ministry of Education, Beijing 100083, China | 2005 | Science China Earth Sciences2005，48，1： | 9 |
| 16 | Effect of rare earth on the microstructure and mechanical properties of as-cast Cu-30Ni alloy显示文摘Cu-30Ni-xRE (x=0-0.213) alloys were prepared by a metal mould casting method. The effect of RE on the microstructure and mechanical properties of the alloys was investigated using optical microscope, scanning electronic microscope with energy-dispersive spectrometer, X-ray diffraction, and mechanical test. The results show that RE has obvious effect on refining dendrite structure and grain size, as well as on purifying the melting of Cu-30Ni alloy. With the increase of RE content, the ultimate tensile strength, yield strength, and elongation increase at first and then decrease after adding RE more than 0.095 wt.%. Cu-30Ni-0.095RE alloy possesses preferable mechanical properties, i.e., the ultimate tensile strength, yield strength, and elongation are 308 MPa, 125 MPa, and 51.2%, respectively. The microstructure and mechanical properties are worsened with increasing RE content more than 0.095 wt.%. The improvement of mechanical properties of Cu-30Ni-0.095RE alloy is attributed to RE refining microstructure and purifying the matrix. | MAO Xiangyang FANG Feng JIANG Jianqing TAN Rongsheng | 2009 | Rare Metals2009，28，6： | 9 |
| 17 | Invasion by alligator weed,Alternanthera philoxeroides,is associated with decreased species diversity across the latitudinal gradient in China显示文摘Aims Invasive species occurrence and their effects on biodiversity may vary along latitudes.We examined the occurrence(species cover)and relative dominance(importance value)of invasive alligator weed,Alternanthera philoxeroides,in its terrestrial habitat in China through a large-scale latitudinal field investigation.Methods We established 59 plots along the latitudinal transect from 21°N to 37°N.We recorded species name,abundance,height and individual species coverage of plants in every quadrat.We then measuredα-species diversity variations associated with the A.philoxeroides community across the latitudinal range.We also analyzed the effect of latitude on plant species’distributions in this community by using canonical correspondence analysis(CCA).Important Findings We found that species cover and importance value of A.philoxe-roides increased in areas<35°N,but decreased at higher latitudes.Lower latitudes supported greater species diversity than higher latitudes.Small-scale invasion of A.philoxeroides was associated with higher species diversity,but community diversity was lower when A.philoxeroides species cover exceeded 36%.Community plant species changed from mesophyte to hygrophyte gradually from low to high latitude.Our research suggests that latitude had significant influences on community diversity which interacted with the biotic resistance of a community and impact of invasion.Consequently,A.philoxeroides may become more invasive and have greater negative impacts on community species diversity in higher latitudes as global climate changes. | Hao Wu Juli Carrillo Jianqing Ding | 2016 | Journal of Plant Ecology2016，9，3： | 8 |
| 18 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 19 | Fluid Inclusions and Metallization of the Kendekeke Polymetallic Deposit in Qinghai Province, China显示文摘The Kendekeke polymetallic deposit, located in the middle part of the magmatic arc belt of Qimantag on the southwestern margin of the Qaidam Basin, is a polygenetic compound deposit in the Qimantag metallogenic belt of Qinghai Province. Multi-periodic ore-forming processes occurred in this deposit, including early-stage iron mineralization and lead-zinc-gold-polymetallic mineralization which was controlled by later hydrothermal process. The characteristics of the ore-forming fluids and mineralization were discussed by using the fluid inclusion petrography, Laser Raman Spectrum and micro-thermometry methods. Three stages, namely, S1-stage(copper-iron-sulfide stage), S2-stage(lead-zinc-sulfide stage) and C-stage(carbonate stage) were included in the hydrothermal process as indicated by the results of this study. The fluid inclusions are in three types: aqueous inclusion(type I), CO2-aqueous inclusion(type II) and pure CO2 inclusion(type III). Type I inclusions were observed in the S1-stage, having homogenization temperature at 240–320oC, and salinities ranging from 19.8% to 25.0%(wt % NaCl equiv.). All three types of inclusions, existing as immiscible inclusion assemblages, were presented in the S2-stage, with the lowest homogenization temperature ranging from 175 oC to 295oC, which represents the metallogenic temperature of the S2-stage. The salinities of these inclusions are in the range of 1.5% to 16%. The fluid inclusions in the C-stage belong to types I, II and III, having homogenization temperatures at 120–210oC, and salinities ranging from 0.9% to 14.5%. These observations indicate that the ore-forming fluids evolved from high-temperature to lowtemperature, from high-salinity to low-salinity, from homogenization to immiscible separation. Results of Laser Raman Spectroscopy show that high density of CO2 and CH4 were found as gas compositions in the inclusions. CO2, worked as the pH buffer of ore-forming fluids, together with reduction of organic gases(i.e. CH4, etc), affected the transport and sediment of the minerals. The fluid system alternated between open and close systems, namely, between lithostatic pressure and hydrostatic pressure systems. The calculated metallogenic pressures are in the range of 30 to 87 Mpa corresponding to 3 km mineralization depth. Under the influence of tectonic movements, immiscible separation occurred in the original ore-forming fluids, which were derived from the previous highsalinity, high-temperature magmatic fluids. The separation of CO2 changed the physicochemical properties and composition of the original fluids, and then diluted by mixing with extraneous fluids such as meteoric water and groundwater, and metallogenic materials in the fluids such as lead, zinc and gold were precipitated. | HUANG Min LAI Jianqing MO Qingyun | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 8 |
| 20 | Discovery of ophiolite in southeast Yunnan,China显示文摘The Babu ophiolite in Malipo County, SE Yunnan, consists of three units: ultramafic, mafic and basaltic rocks. Studies of geological mapping, petrology and geochemistry reveal that the gabbro is similar to that in the Troodos ophiolite, and the diabase and basalt belong to a normal MORB-type,analogous to the Shuanggou ophiolite in west Yunnan. The ophiolite studied as a thrust tectonic slab,was overthrust northwards onto the Late Paleozoic-Triassic deep marine deposits of continental margin.It is inferred to be relics of Paleotethyan ocean; namely, a branch of Paleotethys occurs in South China, where the tectonic nature and evolutional history of the area should be reconsidered. | Dalai Zhong Genyao Wu Jianqing Ji Qi Zhang Lin Ding | 1999 | Chinese Science Bulletin1999，44，1： | 8 |
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